Antihepatotoxic activity of Cichorium intybus

Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology

“…The methanol- and water-soluble fractions exhibited marked reductions in serum glutamyl pyruvate transaminase, serum glutamyl oxaloacetate transaminase, alkaline phosphatase, and total bilirubin levels. In the same study, toxicity was induced in rat hepatocytes by incubation with galactosamine and thioacetamide [38]. …”

Comparative evaluation of traditional prescriptions from Cichorium intybus L. for wound healing: Stepwise isolation of an active component by in vivo bioassay and its mode of activity

“…Similar to Turkey, the dried root of plant is also used to prepare coffee-like beverages and as stomachic in Belgium, France and USA (Mulinacci et al, 2001). On the other hand, the aqueous extract from the seeds is employed against liver diseases and diarrhea in India (Gadgoli and Mishra, 1997), while the fresh shoots are consumed as food and utilized for the treatment of urinary infections and stomachache (Shah et al, 2006).…”

“…Investigations for evaluation of the biological activity have revealed that whole plant extract of C. intybus to possess hepatoprotective and antidiabetic activities (Gadgoli and Mishra, 1997;Manikandan et al, 2007), while the aerial parts to display antioxidant, antimicrobial and anthelmintic effects (Gazzani et al, 2000;Papetti et al, 2002;Petrovic et al, 2004;Foster et al, 2011). On the other hand, a different pharmacological activity profile has been reported for the roots of the plant such as antimalarial, anti-ulcerogenic, analgesic, anti-inflammatory and anticarcinogenic activities (Gürbüz et al, 2002;Bischoff et al, 2004;Petrovic et al, 2004;Cavin et al, 2005;Wesolowska et al, 2006;Conforti et al, 2008).…”

Pharmacognostical-physico-chemical Evaluation and Development of HPTLC Finger print for Cichorium intybus L. fruits

“…9 Alcoholic extract of seeds of C. intybus has been reported to exhibit a potent antihepatotoxic activity on CCl 4 induced liver damage in albino rats. 10 The histopathological study has shown the normalization of the fatty accumulation of the tissues and resolvation of necrosis. 7 Investigation of the hepatoprotective activity of aqueous methanolic extract of C. intybus seed resulted in a significant reduction in death rate, serum levels of alkaline phosphatase, glutamyl oxaloacetate transaminase and glutamyl pyruvate transaminase against acetaminophen and CCl 4 induced hepatic damage in mice.…”