Antihaemophilic effect of vasopressin, deamino‐(<scp>d</scp>‐arginine<sub>8</sub>)‐vasopressin and adrenaline in sheep: proposal for an <i>in vivo</i> assay system

Heiniger, J. P.; Kissling-Albrecht, Luzia; Neuenschwander, Stefan; Rösli, Regula; Pliška, V.

doi:10.1111/j.1476-5381.1988.tb11525.x

Cited by 5 publications

(2 citation statements)

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“…In the rhesus monkey desmopressin stimulates the release of FVIII and vWF (Kinter et al 1992) and in the marmoset monkey plasma levels of FVIII and t‐PA were increased after administration of desmopressin (Vilhardt & Barth 1992; Vilhardt et al 1993). In sheep desmopressin has been shown to increase the plasma levels of FVIII after intravenous administration (Heiniger et al 1988), whereas administration of desmopressin to the pig did not induce any changes in the plasma level of vWF (Bowie et al 1986). The pig V 2 receptor has been shown to be markedly less sensitive to desmopressin than rat, bovine and human V 2 receptors (Ufer et al 1995), a finding that could explain the lack of vWF‐release after desmopressin administration to the pig.…”

Section: V2 Effectsmentioning

confidence: 99%

The Effect of Vasopressin and Related Compounds at V_1a and V₂ Receptors in Animal Models Relevant to Human Disease*

Petersen

2006

Basic Clin Pharma Tox

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Vasopressin, a neurohypophyseal peptide hormone, is the endogenous agonist at V 1a , V 1b and V 2 receptors. The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V 2 receptors in the kidney. Vasopressin and related compounds are used in various clinical settings such as acute variceal bleeding associated with portal hypertension, septic shock, diabetes insipidus and coagulation disorders. The effect in the former two indications relates to the V 1a receptor, and in the two latter indications the effect relates to the V 2 receptor.Vasopressin and related compounds have demonstrated activity in animal models of portal hypertension, sepsis and septic shock, diabetes insipidus and coagulation disorders. The use of the compounds in animal models is reviewed. Generally, the effect of vasopressin and related compounds in animal models reflect the activity in the clinical setting, but in some cases important species differences exist.Vasopressin is a peptide hormone synthesised in the paraventricular and supraoptic nuclei of the hypothalamus. The most important function of the hormone is to induce increased water reabsorption from the kidney collecting ducts, hence its other name antidiuretic hormone. Following synthesis the hormone is transported to the posterior pituitary, where it is stored and released to the bloodstream upon appropriate stimulation. The mechanisms involved in the control of the release of vasopressin are related to osmolality in the plasma and to blood volume. Neurones in the organum vasculosum lamina terminalis represent central osmoreceptors (Bourque & Oliet 1997). These neurones send projections to hypothalamic nuclei containing the magnocellular neurosecretory cells where the production and release of vasopressin take place. Upon hyperosmotic stimulation of the central osmoreceptors magnocellular neurosecretory cells are stimulated to release vasopressin to the blood stream. Peripheral osmoreceptors that control vasopressin release are located in the region containing mesenteric and portal vasculature (Bourque et al. 1994). These sites are strategic for the early detection of increases in osmolality after food and fluid intake. Decreased blood volume is detected by arterial and atrial baroreceptors leading to inAuthor for correspondence: Mads Bjelke Petersen, Non-Clinical Development, Ferring Pharmaceuticals A/S, Kay Fiskers Plads 11, DK-2300 Copenhagen S, Denmark (fax π45 46 77 12 40, e-mail mabp/nycomed.com). * Paper based on a talk at the symposium entitled 'In vivo pharmacology in drug discovery and development' at The Royal Veterinary and Agricultural University, Copenhagen, Denmark, September 10, 2004. creased vasopressin release (Thrasher 1994). The osmotic mechanism for regulation of vasopressin secretion is sensitive to very small increases of plasma osmolality (2% increase causes maximal antidiuresis) whereas 15-20% fall in arterial pressure is required to induce maximal antidiuresis (Baylis 1989). In mo...

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Section: V2 Effectsmentioning

confidence: 99%

The Effect of Vasopressin and Related Compounds at V_1a and V₂ Receptors in Animal Models Relevant to Human Disease*

Petersen

2006

Basic Clin Pharma Tox

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“…Test plasma, or an F-VIII preparation (see above), was diluted with Owren's veronal buffer pH 7.35 (Baxter Dade), usually in ratios of 1:5 to 1:500. The assay was then performed as described in a previous paper [5]: test plasma was mixed with the reagent F-VIII-deficient plasma (ob tained by immunosorption of normal human plasma; produced by Baxter Dade) in a standard volume ratio. Ellagic acid and cephalin (source of phospholipids; Actin, Baxter Dade) were added, and the mixture was incubated for 4 min at 37°C.…”

Section: Assay O F Clotting Timesmentioning

confidence: 99%

Factor VIII in Blood Plasma of Haemophilic Sheep: Analysis of Clotting Time-Plasma Dilution Curves

Neuenschwander¹,

Pliška²

1994

Pathophysiol Haemos Thromb

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The sheep haemophilia A, recently described in a flock of White Alpine sheep, is probably caused by the production of a less potent mutant of factor VIII (F-VIII). Other potential mechanisms, such as drastic reduction (or lack) of F-VIII production, or occurrence of an F-VIII inhibitor, are less likely. This conclusion was based on the analysis of plasma dilution-clotting effect relationships in normal female (anestrous, non-pregnant) sheep, female carriers of haemophilia A, and afflicted male sheep. A response model underlying the analysis was suggested, its validity tested, and a mathematical analysis suitable for routine evaluation procedure recommended.

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Neurohypophyseal hormone analogues and blood coagulation: How successful can a design of “antihemophilic” peptides be?

Pliška¹,

Neuenschwander²

1994

Peptides

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Antihaemophilic effect of vasopressin, deamino‐(d‐arginine₈)‐vasopressin and adrenaline in sheep: proposal for an in vivo assay system

Cited by 5 publications

References 9 publications

The Effect of Vasopressin and Related Compounds at V_1a and V₂ Receptors in Animal Models Relevant to Human Disease*

The Effect of Vasopressin and Related Compounds at V_1a and V₂ Receptors in Animal Models Relevant to Human Disease*

Factor VIII in Blood Plasma of Haemophilic Sheep: Analysis of Clotting Time-Plasma Dilution Curves

Neurohypophyseal hormone analogues and blood coagulation: How successful can a design of “antihemophilic” peptides be?

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Antihaemophilic effect of vasopressin, deamino‐(d‐arginine8)‐vasopressin and adrenaline in sheep: proposal for an in vivo assay system

Cited by 5 publications

References 9 publications

The Effect of Vasopressin and Related Compounds at V1a and V2 Receptors in Animal Models Relevant to Human Disease*

The Effect of Vasopressin and Related Compounds at V1a and V2 Receptors in Animal Models Relevant to Human Disease*

Factor VIII in Blood Plasma of Haemophilic Sheep: Analysis of Clotting Time-Plasma Dilution Curves

Neurohypophyseal hormone analogues and blood coagulation: How successful can a design of “antihemophilic” peptides be?

Contact Info

Product

Resources

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Antihaemophilic effect of vasopressin, deamino‐(d‐arginine₈)‐vasopressin and adrenaline in sheep: proposal for an in vivo assay system

The Effect of Vasopressin and Related Compounds at V_1a and V₂ Receptors in Animal Models Relevant to Human Disease*

The Effect of Vasopressin and Related Compounds at V_1a and V₂ Receptors in Animal Models Relevant to Human Disease*