Antiglycation property of passiflora edulis f. Flavicarpa deg. foliage in type 2 diabetic patients

Chandrasekhar, Dilip; Jose, Sherin Mariya; Jomy, Abiya; Joseph, Anu Yamuna; Pradeep, Anuja; Geoji, Asha Susan

doi:10.1016/j.cegh.2018.07.002

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…In addition to these alternative therapies, other products have also been explored in GDM, including vegetal extracts, mainly aiming to assess the presence of bioactive compounds. However, special attention regarding toxicity must be considered since these products must be innocuous to maternal health, placental tissues, and cytotrophoblast [ 164 , 183 ]. In this regard, to be recognized as safe, these products with potential antioxidant and anti-inflammatory effects must be tested in animal models to provide scientific support for future clinical trials.…”

Section: Alternative Therapies In Gdmmentioning

confidence: 99%

Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies

et al. 2022

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Gestational diabetes mellitus (GDM) is characterized by a set of metabolic complications arising from adaptive failures to the pregnancy period. Estimates point to a prevalence of 3 to 15% of pregnancies. Its etiology includes intrinsic and extrinsic aspects of the progenitress, which may contribute to the pathophysiogenesis of GDM. Recently, researchers have identified that inflammation, oxidative stress, and the gut microbiota participate in the development of the disease, with potentially harmful effects on the health of the maternal-fetal binomial, in the short and long terms. In this context, alternative therapies were investigated from two perspectives: the modulation of the intestinal microbiota, with probiotics and prebiotics, and the use of natural products with antioxidant and anti-inflammatory properties, which may mitigate the endogenous processes of the GDM, favoring the health of the mother and her offspring, and in a future perspective, alleviating this critical public health problem.

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Section: Alternative Therapies In Gdmmentioning

confidence: 99%

Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies

et al. 2022

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“…Higher amounts of phenolic compounds found in passion fruit rind than in juice, direct a potential application of this residue into a product with health promoting appeal to due to the phenolics' capacity of preventing various processes associated with oxidative stress (Chandrasekhar et al 2019). Cazarin et al (2014) studied Passiflora edulis Sims.…”

Section: Resultsmentioning

confidence: 99%

Bioactive content of six passion fruit genotypes cultivated in southern Brazil

et al. 2021

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Passion fruit production in Brazil is concentrated in tropical regions, however, recently production has expanded to regions with temperate climate. Cultivar performance in different climate and soil can lead to variation in the contents of bioactive compounds in the juice and rind of the fruit. This study characterized the bioactive content of passion fruit rind and juice of six passion fruit genotypes (‘Catarina Roxo’, ‘Catarina’, ‘Urussanga’, ‘BRS Gigante Amarelo’, ‘BRS Rubi do Cerrado’, and ‘BRS Sol do Cerrado’) cultivated in southern Brazil. Phenolic, flavonoid, anthocyanin, carotenoid, and ascorbic acid contents and the antioxidant potential of each fruit portion from each genotype were evaluated. Fruit composition varied with genotype and evaluated tissue. Bioactive compound contents were greatest in the rind of ‘Urussanga’ and ‘Catarina’, whereas the juice of ‘BRS Sol do Cerrado’ and ‘Catarina Roxo’ had the greatest bioactive content. Given cultivar and tissue variability for bioactive content, postharvest use of passion fruit will determine the choice of cultivar to obtain a product with maximum bioactive compounds. Passion fruit genotypes evaluated in this study have shown to be potential sources of bioactive compounds. Fruit rind has the potential to be explored in the scientific and technological scope, due to its high amounts of phenolic compounds and antioxidant activity.

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“…The flavonoid isovitexin from Passiflora leaves extract has been studied for its anti-inflammatory activity [28] and its ability to reduce blood glucose levels [22,29]. It can also be used to treat colorectal cancer [30] and type II diabetes [31,32]. This tincture is generally obtained by percolation, an extraction process that requires more than 24 h to perform [18].…”

Section: Introductionmentioning

confidence: 99%

Pressurized Liquid Extraction (PLE) in an Intermittent Process as an Alternative for Obtaining Passion Fruit (Passiflora edulis) Leaf Hydroalcoholic Extract (Tincture)

da Cunha Rodrigues,

Bodini,

Caneppele

et al. 2023

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Tinctures are medicinal plant extracts obtained by extraction with a hydroalcoholic solution (70%) by percolation (PER). This process takes about 26 h to prepare, in addition to using a large amount of solvent. In our research, passion fruit leaf tinctures were obtained using extract with the same pressurized hydroalcoholic solution as in an intermittent process. The objective was to demonstrate that this emerging technology can be economical and profitable. An optimization using Central Composite Rotatable Design (CCRD) was performed to evaluate the influence of process variables on the yields and compositions of the extracts. The temperature (T) was the factor that most influenced the responses. Extraction with pressurized liquid (PLE) provided total yields and total phenolic and flavonoid contents in greater amounts than PER. The optimized conditions of the process variables studied in the CCRD for the highest content of total phenolics (43.2 mg GAE/g) and flavonoids (58.8 mg QE/g) were at 100 °C with a rinse volume of 120% of the divided extractor volume in four cycles of the intermittent process. When adjusting the PLE in an intermittent process, and according to the one-dimensional mass transfer by the continuous diffusion of the Fick model, the effective diffusion coefficient (1.28 × 10−12 m2/s) was not affected by T. The kinetic curve of PLE extraction indicates that the adjusted intermittent process occurred in the period of the constant extraction rate when compared to the kinetics of the semi-continuous process. The yielded extracts were rich in isovitexin, and the highest levels were identified in the extracts obtained via PLE, indicating that this intermittent process can bring a product to market with the same quality but with a much shorter production time and the use of fewer solvents. Antioxidant activity, determined by DPPH, FRAP and ORAC, was also higher in extracts obtained via PLE.

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Antiglycation property of passiflora edulis f. Flavicarpa deg. foliage in type 2 diabetic patients

Cited by 8 publications

References 10 publications

Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies

Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies

Bioactive content of six passion fruit genotypes cultivated in southern Brazil

Pressurized Liquid Extraction (PLE) in an Intermittent Process as an Alternative for Obtaining Passion Fruit (Passiflora edulis) Leaf Hydroalcoholic Extract (Tincture)

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