Antigiardial Activity of Isoflavones from <i>Dalbergia frutescens</i> Bark

Khan, IA; Avery, Mitchell A.; Burandt, Charles L.; Goins, D K; Mikell, Julie Rakel; Nash, Theodore E.; Azadegan, and A.; Walker, Larry

doi:10.1021/np000010d

Cited by 91 publications

(60 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11) Spectral data ( 13 C-NMR, Table 1) resembled those published for 4Ј,6-dimethoxy-7-hydroxy-isoflavone (1) known as afrormosin 12) and castanin 13) respectively and 4Ј,6-dimethoxy-5Ј,7-dihydroxy-isoflavone (2) known as odoratin, which have been previously detected in D. odorata and Glycine max respectively. 4,5,11,12) Final confirmation of the structure of compounds 1 and 2 was achieved through X-ray diffraction analysis (Figs.…”

Section: T Cruzi Gapdh-inhibitory Activitysupporting

confidence: 59%

Isolation and Structure Determination of Bioactive Isoflavones from Callus Culture of Dipteryx odorata

Januário

Lourenço

Domézio

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Great commercial value has been credited to the seeds of Dipteryx odorata WILLD. (AUBL.) (Leguminoseae) native from Amazon and also known as tonka beans or cumaru, because they are considered rich source of coumarins, used in cosmetics and perfumery.1) The presence of umbelliferone in seeds of tonka beans was described by Sullivan who also reported other natural compounds like isoflavonoids, triterpenoids, fatty acids and cassane diterpenoids on seeds of this species.2) Additionally some micromolecules specific of the heartwood of D. odorata as isoflavones retusin, retusin 8-methyl ether, 3Ј-hydroxyretusin 8-methyl ether, odoratin, dipteryxin, dipteryxine and odoratine; the triterpenes lupeol and betulin; and methyl esters of fatty acids have been isolated. 3,4) Isoflavonoids have gained considerable importance due to the diverse broad of biological activities correlated to them, including antioxidative, oestrogenic, inseticidal, piscicidal, antifungal, antimicrobial and contraceptive properties. 5,6) The pharmacological properties of isoflavonoids and the correlation between the consumption of isoflavonoids and reduction on the level of incidence of cardiovascular disease and cancer have increase the interest in the search for biologically active compounds from plant species of both, leguminous and non-leguminous sources. 7)In this work we report the establishment of D. odorata callus cultures focusing on a comparative study related to the production of tripanossomatidal GAPDH inhibitory isoflavones accumulated in roots of the intact plant and in callus cultures of this species. ExperimentalPlant Material Dipteryx odorata plants were collected in the campus of Universidade do Amazonas in Manaus, Brazil. Voucher specimen is deposited under the number HUAM 7276 in the Herbarium of the Universidade do Amazonas.Seed Disinfestations Seeds of D. odorata were soaked in sterile distilled water and maintained under agitation overnight. Seeds were then immersed in 2% Benomyl solution for 4 h under agitation, washed in 70% hydroalcoholic solution, dipped in 1% CaClO for 40 min, washed for three times with sterile distilled water and inoculated into glass flasks (8.5 cmϫ2.5 cm i.d.) containing 5 ml MS medium 8) added with 30 g/l sucrose and 2.0 g/l Phytagel, pH was adjusted to 6.0 before autoclaving. Flasks were sealed with polypropylene closures (Bellco), autoclaved at 121°C and 105 kPa for 20 min and maintained at 25Ϯ2°C, 55-60% relative humidity under 16 h photoperiod with 40 mmol m Ϫ2 s Ϫ1, 85 W coolwhite GE fluorescent lamps.Callus Induction Leaves, hypocotyl, and roots of D. odorata seedlings produced in vitro were used as explants for callus induction. Explants were inoculated onto semisolid MS medium supplemented with 2.0 mg/l 2,4-D, 0.5 mg/l 6-BAP and 340 mg/l KH 2 PO 4 and 2.0 g/l Phytagel, pH ajusted to 6.0. Callus were harvested and subcultured in 30-d intervals.General Analytical Procedures TLC was carried out on silica gel G pre-coated plates (Sigma-Aldrich) using CHCl 3 -MeOH (9 : 1) as solvent system. Spots...

show abstract

Section: T Cruzi Gapdh-inhibitory Activitysupporting

confidence: 59%

Isolation and Structure Determination of Bioactive Isoflavones from Callus Culture of Dipteryx odorata

Januário

Lourenço

Domézio

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…Flavonoids are also recognized moiety for antifungal, cytotoxic, neuroprotective and HIVinhibitory antimicrobial and antifungal properties [6][7][8][9][10][11][12][13] . The synthesis, spectral study and biological activity significance for flavone molecule 6-chloro-2-(furan-2-yl)-4-oxo-4H-chromen-3-yl acetate was reported [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Crystal Structure, Thermal Behavior and UV Spectroscopy of 6-Chloro-2-(furan-2-yl)-4-oxo-4H-chromen-3-yl Acetate

2018

Chem Sci Trans

View full text Add to dashboard Cite

6-Chloro-2-(furan-2-yl)-4-oxo-4H-chromen-3-yl acetate consist of acetylated 2-furan substituted chromene molecule was prepared. The single crystal of compound was obtained by the slow evaporation technique. Thermal studies were carried out by thermogravimetric (TGA) and differential calorimetric analysis (DSC). The crystal structure was obtained by single crystal x-ray diffraction which crystallizes in the monoclinic space group P2 1 /n with cell parameter a= 5.0656(3) Å, b= 4.4661(10) Å, c= 18.4123(14) Å and Z = 4.

show abstract

“…derivatives are abundant in nature and possess pharmacological activity [2]. chromone derivatives neuroprotective [6] , HIV-inhibitory [7], antimicrob antioxidant activity [11]. Due to their abundance in plants and their low mammalian toxicity, chromone are present in large amounts in the diet of The synthesis of chromone derivatives is a research f of great interest and long history [ mones are synthesized by the cyclodehydration of 1 hydroxyaryl)-substances that favor healing and ulcers [15] immunostimulators agents [17].…”

Section: Introductionmentioning

confidence: 99%

QSAR, Docking and Invitro Antioxidant Activity Study of Novel Chromone Derivatives

Shanthi¹,

Ramesh²,

Srimai³

et al. 2013

View full text Add to dashboard Cite

:Invitro antioxidant activity and Molecular modeling studies of nine chromone derivatives optimize their inhibitory activity against Poly [ADP correlated to different molecular properties. The AM1and PM3 semiempirical methods are used to estimate vertical ioniz tion potentials (IPv's), electron affinity (EA tion coefficient (LogP), hydration energ regression analysis are proposed. The leave final QSAR equations. The hardness (η) was found to be studies of chromone with Poly [ADP-ribose results of both QSAR and Docking studies suggested that remarkable inhibi hydrogen bond interactions along with hydrophobic and electrostatic interactions

show abstract

Antigiardial Activity of Isoflavones from Dalbergia frutescens Bark

Cited by 91 publications

References 17 publications

Isolation and Structure Determination of Bioactive Isoflavones from Callus Culture of Dipteryx odorata

Isolation and Structure Determination of Bioactive Isoflavones from Callus Culture of Dipteryx odorata

Crystal Structure, Thermal Behavior and UV Spectroscopy of 6-Chloro-2-(furan-2-yl)-4-oxo-4H-chromen-3-yl Acetate

QSAR, Docking and Invitro Antioxidant Activity Study of Novel Chromone Derivatives

Contact Info

Product

Resources

About