Antigens of bacteria associated with periodontitis

O'Brien-Simpson, Neil M; Veith, Paul D.; Dashper, Stuart G.; Reynolds, Eric C.

doi:10.1111/j.0906-6713.2004.003559.x

Cited by 98 publications

(82 citation statements)

References 422 publications

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“…3 LPS acts as a potent stimulus to a variety of host cells, which subsequently results in the expression of inflammatory cytokines leading to the development and progression of the related host immune response in periodontal diseases. 4 Numerous studies have demonstrated that cytokine networks play an important role in the initiation and progression of periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

Periodontal ligament and gingival fibroblasts participate in the production of TGF-β, interleukin (IL)-8 and IL-10

et al. 2011

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The aim of this study was to quantify and compare the production of transforming growth factor beta (TGF-β), interleukin (IL)-8 and IL-10 by human cultured periodontal ligament and gingival fibroblasts both obtained from the same donors challenged with lipopolysaccharide (LPS) from Porphyromonas gingivalis. Fibroblasts were exposed to 0.1-10 µg/mL of LPS from P. gingivalis and after 24 h the supernatants were collected and analyzed by enzyme-linked immunosorbent assay (ELISA). TGF-β protein production was upregulated in a concentration-dependent manner, mainly in gingival fibroblasts, which was statistically significant when challenged by 10 µg/mL LPS. Additionally, at this concentration, gingival fibroblasts had almost a two-fold increase in the amount of TGF-β when compared to periodontal ligament fibroblasts. Both periodontal ligament and gingival fibroblasts showed an increase in IL-8 production when challenged with 1 µg/mL and 10 µg/mL LPS. IL-10 production remained unaffected when challenged by any of the LPS concentrations tested in either periodontal ligament or gingival fibroblasts. Our results demonstrate that periodontal ligament and gingival fibroblasts when challenged by LPS from P. gingivalis with 24 h may play a critical role in producing TGF-β and IL-8 but not IL-10.

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Section: Introductionmentioning

confidence: 99%

Periodontal ligament and gingival fibroblasts participate in the production of TGF-β, interleukin (IL)-8 and IL-10

et al. 2011

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“…Mediators of oxidative stress or ''redox signaling'' or both have been shown to regulate receptor (11) and transcription factor signaling (48) and to induce NF-kB (31) and kinasedependent signaling pathways (50), thereby inducing the expression of key cytokines (26) and inflammatory mediators. Oxidative stress can shift the balance of Th1 and Th2 cytokine profiles in in vitro (52) and in vivo model systems (47 and 53), typically toward a Th2 cytokine profile, suggesting that oxidative stress might modify humoral immune responses to commensal and pathogenic microorganisms.…”

mentioning

confidence: 99%

Association of Systemic Oxidative Stress with Suppressed Serum IgG to Commensal Oral Biofilm and Modulation by Periodontal Infection

Singer

Moss

Beck

et al. 2009

Antioxidants & Redox Signaling

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“…An extensive review of the literature revealed that lipopolysaccharide or outer membrane lipids, polysaccharide, fimbriae and outer membrane, and secreted proteins are antigens of all four bacteria that may play a role in disease pathogenesis [28].…”

Section: Antigen and Host Inflammatory Reactionmentioning

confidence: 99%