Association of Systemic Oxidative Stress with Suppressed Serum IgG to Commensal Oral Biofilm and Modulation by Periodontal Infection

Singer, Robert E.; Moss, Kevin; Beck, James D.; Offenbacher, S.

doi:10.1089/ars.2009.2591

Cited by 27 publications

(35 citation statements)

References 61 publications

(54 reference statements)

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“…Multivariate models were developed for serum CRP levels for each of the 16 oral biofilm IgG antibodies and 4 clusters of IgG antibodies that represent total biofilm IgG, total red IgG, total orange IgG, and total other IgG (Singer et al 2009). The IgG clusters (i.e., other, orange, and red) were directed against microbial species associated with health, gingivitis, and periodontitis, respectively (Sakellari et al 1997).…”

Section: Discussionmentioning

confidence: 99%

“…The findings in this report suggest a mechanistic model that appears in Figure 2. Specifically, oxidative stress shifts Th cell and antigen-presenting cell responses such that Th-1 cell and plasma cell functions likely become impaired (Singer et al 2009), thereby decreasing IgG antibody responses against oral bacteria. Decreased serum-neutralizing IgG antibodies to oral bacteria enable plaque microbial toxins/ molecules to enter the circulation and/or increase release of cytokines from the inflamed periodontium.…”

Section: Discussionmentioning

confidence: 99%

“…The d-8-iso PGF 2α assay was conducted on serum samples of ARIC subjects as previously described (Singer et al 2009). Participants were ranked in quartiles based on their serum concentration of d-8-iso PGF 2α .…”

Section: Serum 8-isoprostanementioning

confidence: 99%

“…Previously, we reported (Singer et al 2009) that physiologic increases in serum 8-isoprostane levels, a stable lipid marker of oxidative stress, are associated with decreased serum IgG 602693J DRXXX10.1177/0022034515602693Journal of Dental ResearchOxidative Stress and IgG Antibody Modify Periodontitis-CRP Association research-article2015 antibody levels against 17 oral bacteria, including periodontal pathogens. Quartiles of increased serum 8-isoprotane were associated with significant decreases in all 17 serum IgG antibodies.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress and IgG Antibody Modify Periodontitis-CRP Association

et al. 2015

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In a previous report, we demonstrated the inverse association of high serum 8-isoprostane levels, a marker for oxidative stress, with decreased serum IgG antibodies to oral bacteria. The association between increased serum IgG with increased plaque and periodontitis (increased probing depths) was attenuated by high systemic oxidative stress. Other investigations have reported a role for systemic oxidative stress as a stimulus of hepatic C-reactive protein (CRP) response. These observations led us to hypothesize that the reported relationship of periodontitis to elevated serum CRP, a systemic inflammatory marker, may be modified by oxidative stress and that the levels of serum antibodies to oral bacteria might be an intermediary explanatory variable linking the association of systemic oxidative stress, periodontal disease, and levels of CRP. This hypothesis was explored as a secondary analysis of the Dental ARIC (Atherosclerosis Risk in Communities) study using serum levels of CRP, serum IgG levels to 16 oral organisms, serum levels of 8-isoprostane, and periodontal status. The findings indicate periodontitis is associated with high CRP in the presence of elevated oxidative stress that serves to suppress the IgG response. Only within the highest 8-isoprostane quartile was periodontitis (pocket depth) associated with increased serum CRP levels (P = 0.0003). Increased serum IgG antibody levels to oral bacteria were associated with lowered serum CRP levels. Thus, systemic oxidative stress, which has been demonstrated to be associated with increased levels of CRP in other studies, appears to be associated with the suppression of bacterial-specific IgG levels, which in the presence of periodontal disease can result in an enhanced systemic CRP response. Conversely, individuals with increased serum IgG antibodies to plaque bacteria exhibit lowered serum CRP levels. These 2 factors, oxidative stress and the serum IgG response, appear to function in opposing directions to modify serum levels of CRP and the association with periodontitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Serum 8-isoprostanementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress and IgG Antibody Modify Periodontitis-CRP Association

et al. 2015

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“…However, one could also combine both the explanations, because there has been a significant decrease in an overall antioxidant protection in planktonic cells during the stationary phase, and a strong reduction in the level of DCF-DA oxidation to its fluorescent form in the stationary phase of biofilm. Several authors have previously proposed a protective mechanisms for biofilm formed by the microorganisms other thanE.coli (Albesa et al 2004;Singer et al 2009;Arce Miranda et al 2011;Villegas et al 2013). The results have shown an interesting relationship -cells of biofilm have a higher resistance to the mediators that produce hydroxyl radical, but in the case of exposure to the superoxide anion, the nature of this relationship is reversed -which means that they are more resistant than the planktonic forms.…”

Section: Resultsmentioning

confidence: 99%

Resistance of oxidative stress in biofilm and planktonic cells

Jakubowski

Walkowiak

2015

Braz. arch. biol. technol.

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Expression of immunoregulatory genes and its relationship to lead exposure and lead‐mediated oxidative stress in wild ungulates from an abandoned mining area

Rodríguez-Estival

Lastra

Ortiz‐Santaliestra

et al. 2013

Enviro Toxic and Chemistry

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Abstract-Lead (Pb) is a highly toxic metal that can induce oxidative stress and affect the immune system by modifying the expression of immunomodulator-related genes. The aim of the present study was to investigate the association between Pb exposure and the transcriptional profiles of some cytokines, as well as the relationship between Pb exposure and changes in oxidative stress biomarkers observed in the spleen of wild ungulates exposed to mining pollution. Red deer and wild boar from the mining area studied had higher spleen, liver, and bone Pb levels than controls, indicating a chronic exposure to Pb pollution. Such exposure caused a depletion of spleen glutathione levels in both species and disrupted the activity of antioxidant enzymes, suggesting the generation of oxidative stress conditions. Deer from the mining area also showed an induced T-helper (T h )-dependent immune response toward the T h 2 pathway, whereas boar from the mining area showed a cytokine profile suggesting an inclination of the immune response toward the T h 1 pathway. These results indicate that environmental exposure to Pb may alter immune responses in wild ungulates exposed to mining pollution. However, evidence of direct relationships between Pb-mediated oxidative stress and the changes detected in immune responses were not found. Further research is needed to evaluate the immunotoxic potential of Pb pollution, also considering the prevalence of chronic infectious diseases in wildlife in environments affected by mining activities. Environ. Toxicol. Chem. 2013;32:876-883.

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Association of Systemic Oxidative Stress with Suppressed Serum IgG to Commensal Oral Biofilm and Modulation by Periodontal Infection

Cited by 27 publications

References 61 publications

Oxidative Stress and IgG Antibody Modify Periodontitis-CRP Association

Oxidative Stress and IgG Antibody Modify Periodontitis-CRP Association

Resistance of oxidative stress in biofilm and planktonic cells

Expression of immunoregulatory genes and its relationship to lead exposure and lead‐mediated oxidative stress in wild ungulates from an abandoned mining area

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