Antigenotoxicity and Tumor Growing Inhibition by Leafy Brassica carinata and Sinigrin

Lozano-Baena, María Dolores; Tasset, Inmaculada; Obregón-Cano, Sara; Bailón, Antonio de Haro; Muñoz-Serrano, A.; Alonso-Moraga, Ángeles

doi:10.3390/molecules200915748

Cited by 32 publications

(18 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The human acute promyelocytic leukemia cell line HL-60 has been used as a model on a wide variety of substances that are candidates to be used as anticarcinogens and has proved to be a robust test system for pilot screening experiments [ 30 , 39 , 60 ]. That is why we have selected this system to elucidate the inhibitory capacity of tumour growth for the different samples studied.…”

Section: Resultsmentioning

confidence: 99%

“…The complexity of plant composition and the human digestion process requires validated models that represent this relation as closely and in a manner as valuable for research as possible. For this reason, we have selected the in vivo Drosophila melanogaster and in vitro HL-60 human cancer cell system as two complementary, sensitive, low-cost and rapid eukaryotic assays, able to detect the potential mutagenic and carcinogenic effects of tested compounds [ 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

et al. 2016

Self Cite

View full text Add to dashboard Cite

Nowadays, healthy eating is increasing the demand of functional foods by societies as sources of bioactive products with healthy qualities. For this reason, we tested the safety of the consumption of Borago officinalis L. and its main phenolic components as well as the possibility of its use as a nutraceutical plant to help in cancer prevention. The in vivo Drosophila Somatic Mutation and Recombination Test (SMART) and in vitro HL-60 human cell systems were performed, as well-recognized methods for testing genotoxicity/cytotoxicity of bioactive compounds and plant products. B. officinalis and the tested compounds possess antigenotoxic activity. Moreover, B. officinalis wild type cultivar exerts the most antigenotoxic values. Cytotoxic effect was probed for both cultivars with IC50 values of 0.49 and 0.28 mg·mL−1 for wild type and cultivated plants respectively, as well as their constituent rosmarinic acid and the assayed phenolic mixture (IC50 = 0.07 and 0.04 mM respectively). B. officinalis exerts DNA protection and anticarcinogenic effects as do its component rosmarinic acid and the mixture of the main phenolics presented in the plant. In conclusion, the results showed that B. officinalis may represent a high value plant for pleiotropic uses and support its consumption as a nutraceutical plant.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…23 Sinigrin, an abundant glucosinolate of B. carinata exhibited an antigenotoxic and anti-tumor activitiesin Drosophila melanogaster(SMART) in vivo and in HL60 (human promyelocytic leukaemia cell line) systems in vitro. 70 Rosmarinic acid, the major phenolic compounds of Salvia sp protected Caco-2 and HeLa cells against genotoxicity of hydrogen peroxide and increased DNA repair activity in Caco-2 cells. 71 Baccharin, the bioactive compounds isolated from the aerial parts of Baccharis dracunculifolia inhibits the genotoxic effects of methyl methane sulfonate and hydrogen peroxide in V79 cells.…”

Section: Other Phenolic Compoundsmentioning

confidence: 99%

Chemopreventive compounds from plant derived food and their bioactivity

Rouamba¹,

Compaoré²,

Kiendrebéogo

2018

Asian J Med Sci

View full text Add to dashboard Cite

Terrestrial plants, especially higher plants, have a long history of use for the treatment of many human diseases such as ailment, cancer, diabetes, neurodegenerative and cardiovascular disorders. Since then, many studies have been designed to evaluate biochemical properties of whole plant extract, fractions or isolated compounds. Several researches have established the relation between consumption of plant derived products to minimize the oxidative stress and diseases associated with stress. These beneficial biological properties on animal health has been attributed to certain classes of metabolites contents in plants including anthocyanins, flavonols, tannins, carotenoids, terpenoids, alkaloids and vitamins. The bioactivity of these compounds is due to their ability to scavenge reactive oxygen species (ROS) or NOS or to modulate antioxidant enzymes expression. The devastating environmental pollution has burdened with numerous toxic chemicals of which biological compounds such as nucleic acid, proteins and membrane phospholipids were the potential targets leading to mutation, cell injury and death. The endogenous antioxidant systems falls prey in response to these toxic and deleterious oxidants and reactive oxygen species. In these conditions, exogenous chemopreventive compounds extracted from plant derived foods are required to maintain cell hemostasis. This review highlights the source and the chemopreventive mechanisms of genoprotective compounds from plant derived food.Asian Journal of Medical Sciences Vol.9(5) 2018 1-7

show abstract

“…Antigenotoksinler, genotoksik ajanların etkilerini önleme veya azaltma yeteneğine sahip olan maddelerdir. Bitkilerde bulunan fenolik bileşenler, flavonoidler, alkoidler gibi çeşitli fitokimyasalların antigenotoksik özelliğe sahip olduğu bilinmektedir [2][3][4]. Yapılan araştırmalarda organizmalarda doğal olarak bulunan detoksifikasyon mekanizmalarının yanı sıra vücuda beslenme yolu ile alınan antigenotoksik etkiye sahip fitokimyasalların genotoksinlerin zararlı etkilerini önlemekte etkili oldukları gösterilmiştir [5,6].…”

Section: Introductionunclassified

Myrtus communis L. (Mersin) Yaprak Ekstraktının Genoprotektif Etkisinin Somatik Mutasyon ve Rekombinasyon Testi ile Değerlendirilmesi

Öz

Arıca

2019

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi

View full text Add to dashboard Cite

Öz Bu çalışmada Myrtus communis L. (mersin) yaprak ekstraktının genoprotektif etkisi somatik mutasyon ve rekombinasyon testi (SMART) ile incelendi. Yüksek genotoksik etkiye sahip kemoterapötik bir ajan olan doksorubisin (DXR) pozitif kontrol olarak kullanıldı. Test maddeleri flare (flr 3) ve çoklu kanat kılı (mwh) mutant işaret genlerini taşıyan üç günlük (72±4 saat) transheterozigot Drosophila melanogaster larvalarına uygulandı. Mersin yaprak ekstraktı, genotoksik etkisini değerlendirmek için tek başına (1,5 ve 10 mg/ml), antigenotoksik etkisini değerlendirmek için doksorubisin (0,125 mg/ml) ile uygulandı. İnhibisyon yüzdeleri 1, 5 ve 10 mg/ml dozlarında sırasıyla %91,70, %97,51 ve %98,34 olarak hesaplandı. Bu çalışmadan elde edilen sonuçlara göre mersin yaprak ekstraktı test edilen tüm dozlarda doksorubisin kaynaklı mutant klon oluşumunu inhibe ederek antigenotoksik etki gösterdi.

show abstract

Antigenotoxicity and Tumor Growing Inhibition by Leafy Brassica carinata and Sinigrin

Abstract: ) and the breakdown products of sinigrin hydrolysis (IC50 = 2.71 µM). Our results enhance the potential of B. carinata as health promoter and chemopreventive in both systems and the leading role of sinigrin in these effects.

Cited by 32 publications

References 48 publications

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

Chemopreventive compounds from plant derived food and their bioactivity

Myrtus communis L. (Mersin) Yaprak Ekstraktının Genoprotektif Etkisinin Somatik Mutasyon ve Rekombinasyon Testi ile Değerlendirilmesi

Contact Info

Product

Resources

About