Antigen Specific IgG4 in Patients with Gastrointestinal Complaints

Priedite, Viktorija; Nikiforenko, Jevgenij; Kurjāne, Nataļja; Kroiča, Juta

doi:10.9734/bjmmr/2014/5696

Cited by 6 publications

(9 citation statements)

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“… 2 – 4 The prevalence of food intolerance is believed to be 5–20% of the general population; however, the true prevalence of food intolerance remains unknown due to insufficient data. 5 IgG-mediated food intolerance is believed to be caused by increased gut permeability, which permits food substances to gain access to the circulation and trigger food specific IgG production. 3 Increased production of food specific IgG antibodies coupled with decreased production of anti-inflammatory cytokines such as IL-10 and TGFβ1 have been implicated in irritable bowel syndrome.…”

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confidence: 99%

“… 2 , 9 Similarly, a strong association between neurological manifestations such as migraine and IgG-mediated food intolerance has also been reported. 5 , 10 Recently, in follow-up studies, food intolerance has been linked with disorders such as atherosclerosis and asthma. Prohibiting ingestion of incriminating food that patients were intolerant to resulted in significant improvement in symptom scores.…”

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confidence: 99%

“… 8 , 9 , 11 , 12 Most common non-specific symptoms such as chronic fatigue and hair loss have also been associated with IgG-mediated food intolerance. 3 , 5 , 7…”

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confidence: 99%

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Prevalence of IgG-mediated food intolerance among patients with allergic symptoms

Shakoor

Alfaifi

AlAmro

et al. 2016

Annals of Saudi Medicine

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BACKGROUNDFood intolerance mediated by food specific IgG antibodies has been implicated in a variety of disorders.OBJECTIVESTo assess the prevalence of food specific IgG antibodies among patients clinically presenting with allergic symptoms lacking laboratory evidence of allergy.DESIGNDescriptive retrospective cross-sectional study.SETTINGKing Khalid University Hospital, Riyadh between 2010–2015.PATIENTS AND METHODSPatients were screened for food specific IgG antibodies. All symptomatic patients lacking laboratory evidence of allergy who underwent food specific IgG testing during the study duration were included.MAIN OUTCOME MEASURE(S)Levels of IgG antibodies in patients with unidentified allergic symptoms.RESULTSWe selected 71 patients with allergic symptoms lacking laboratory evidence of allergy. There were 49 female and 22 male patients mean age 38.8 (16.0) years. The majority (85.7%) had urticaria. The most frequently occurring food specific IgG antibodies were against cola nut in 80.3% of patients followed by yeast in 78.9%, wheat in 77.5%, red kidney bean in 71.8%, pea in 63.4%, corn in 62% and egg white in 62% of the patients. Compared with male patients, females harbored significantly higher food specific IgG antibodies for frequently occurring food materials, particularly against wheat (74% vs 25.5%; P<.0001), corn (77.3% vs 22.7%; P<.0001) and cola nut (71.9% vs 28.1%; P<.001). Patients aged less than 40 years had higher levels of food specific IgG against gliadin (P<.003), egg white (P<.03) and barley (P<.05) compared with older patients.CONCLUSIONThe detection of a variety of food specific IgG antibodies among patients with allergic symptoms indicates a possible link to food intolerance allergy. Females are prone to develop food intolerance more than males.LIMITATIONSDifficulty of comparison of results with previous studies because of lack of data. Follow-up studies could not be performed to assess the effects of elimination from the diet due to limited time allocated for this study.

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Prevalence of IgG-mediated food intolerance among patients with allergic symptoms

Shakoor

Alfaifi

AlAmro

et al. 2016

Annals of Saudi Medicine

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“…In despite of conflicting reports, the detection of a variety of food-specific IgG antibodies has being actively promoted and adopted by some commercial companies (Nettleton et al, 2009). A strong association between neurological manifestations such as migraine and IgG-mediated FIs had also been reported (Mitchell et al, 2011;Priedite et al, 2014). Therefore, in this study, ELISA method was used to detect the different food-specific IgG antibodies in the serum of healthy examined people aging from 20 to 70 years old, aiming at providing references for the diagnosis of clinical FI and guiding people healthy meals.…”

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confidence: 99%

Preliminary analysis on food intolerances of 88,436 healthy people to 14 kinds of foods

Zheng¹,

Zhang

Zeng

et al. 2019

BFJ

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Purpose Functional disorders caused by food intolerance (FI) are prevalent, thus it is important to analyze the FI of healthy people to common foods so as to guide the people for eating the healthy foods. The paper aims to discuss this issue. Design/methodology/approach In total, 88,436 healthy persons including 60,902 males and 27,534 females at the age ranging from 20 to 70 years old were subjected a normal physical examination. In total, 14 kinds of food-specific IgG antibodies were detected by enzyme-linked immunesorbent assay. Findings The total positive rate of 14 FIs was as high as 64.16 percent. Five kinds of foods (egg, crab, cod, shrimp and milk) accounted for 84.51 percent of the total positive rate. In more than one kind of FIs, egg took the largest proportion than the others and the proportion was 58.54 percent. The second was crab with a positive rate of 56.19 percent. The antibody positive rate of any food in one kind of FIs was significantly lower than that in more than one kind of FIs (χ2=629.35, p<0.001). Also, younger age subjects displayed the higher positive rate than the older age groups. In addition, there was no significant difference on FI between male and female subjects. Originality/value The results would not only prompt us to pay more attention to FI in daily life, but provide theoretical foundation for the early prevention, diagnosis and treatment of related clinical diseases as well as guiding people healthy meals.

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“…Food intolerance is a widespread condition in the global populationit is estimated that between 5 to 45% of the people could be affected [1,2]. The problem is also topical for Bulgaria, but so far no studies have been conducted on the prevalence of IgG based intolerance to various foods.…”

Section: Introductionmentioning

confidence: 99%

Meat Food Intolerance-Prevalence among the Bulgarian Population, Main Characteristics and Health Significance

Agovska¹,

Nikolova²

2021

J Epidemiol Public Health Rev

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Antigen Specific IgG4 in Patients with Gastrointestinal Complaints

Cited by 6 publications

References 0 publications

Prevalence of IgG-mediated food intolerance among patients with allergic symptoms

Prevalence of IgG-mediated food intolerance among patients with allergic symptoms

Preliminary analysis on food intolerances of 88,436 healthy people to 14 kinds of foods

Meat Food Intolerance-Prevalence among the Bulgarian Population, Main Characteristics and Health Significance

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