Antigen handling in aging II. The role of Kupffer and endothelial cells in antigen processing in fischer 344 rats

Caperna, Thomas J.; Garvey, James E.

doi:10.1016/0047-6374(82)90088-4

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…However, colloidal carbon is also taken up by LSEC endocytosis (Fujita et al,1983); therefore, these results may need to be re‐interpreted. In a study by Brouwer et al (1985), the in vivo LSEC capacity for uptake of colloidal (heat‐aggregated) albumin in rat was not influenced by age but other studies have reported a 53% reduction of in vivo LSEC uptake of azoaniline‐albumin in 22–24 month rats compared with 6–8 month rats (Caperna and Garvey,1982), and a 80% reduction of in vivo LSEC uptake of sulfanilate‐azo‐albumin in 28 month rats compared with 12 month rats (Heil et al,1984), Interestingly, in the three age groups analyzed by Heil et al (1984), the endocytosis of sulfanilate‐azo‐albumin peaked at 12 months of age, whereas the uptake in 28 month rats equaled that of 4 month rats.…”

Section: Old Age and The Hepatic Sinusoidmentioning

confidence: 97%

“…The effects of age on Kupffer cell endocytic activity are inconsistent. The uptake of colloidal carbon is either reduced by 35% (Videla et al,2001) or unchanged (Vomel et al,1981; De Leeuw et al,1983; Yamano et al,2000), whereas the uptake of denatured albumin has usually been reported to be reduced, by 23% (but not statistically significant) between 6 and 22 months in rats (Caperna and Garvey,1982), 58% between 12 and 28 months in rats (Heil et al,1984) and by 40% between 6 and 36 months in rats (Brouwer et al,1985). These conclusions may be influenced by any aging effects on LSEC endocytosis of these substrates (Hilmer et al,2007).…”

Section: Old Age and The Hepatic Sinusoidmentioning

confidence: 99%

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Old Age and the Hepatic Sinusoid

Couteur

Warren

Cogger

et al. 2008

The Anatomical Record

151

133

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Morphological changes in the hepatic sinusoid with old age are increasingly recognized. These include thickening and defenestration of the liver sinusoidal endothelial cell, sporadic deposition of collagen and basal lamina in the extracellular space of Disse, and increased numbers of fat engorged, nonactivated stellate cells. In addition, there is endothelial upregulation of von Willebrand factor and ICAM-1 with reduced expression of caveolin-1. These changes have been termed age-related pseudocapillarization. The effects of old age on Kupffer cells are inconsistent, but impaired responsiveness is likely. There are functional implications of these aging changes in the hepatic sinusoid. There is reduced sinusoidal perfusion, which will impair the hepatic clearance of highly extracted substrates. Blood clearance of a variety of waste macromolecules takes place in liver sinusoidal endothelial cells (LSECs). Previous studies indicated either that aging had no effect, or reduced the endocytic capacity of LSECs. However, a recent study in mice showed reduced endocytosis in pericentral regions of the liver lobules. Reduced endocytosis may increase systemic exposure to potential harmful waste macromolecules such as advanced glycation end products Loss of fenestrations leads to impaired transfer of lipoproteins from blood to hepatocytes. This provides a mechanism for impaired chylomicron remnant clearance and postprandial hyperlipidemia associated with old age. Given the extensive range of substrates metabolized by the liver, age-related changes in the hepatic sinusoid and microcirculation have important systemic implications for aging and age-related diseases. Anat Rec,

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Section: Old Age and The Hepatic Sinusoidmentioning

confidence: 97%

Section: Old Age and The Hepatic Sinusoidmentioning

confidence: 99%

Old Age and the Hepatic Sinusoid

Couteur

Warren

Cogger

et al. 2008

The Anatomical Record

151

133

View full text Add to dashboard Cite

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“…Typically, such modifications lead to neutralization of positively charged amino groups, increasing the net negative charge of the protein and thus their affinity for SRs (22,166). Results are not fully consistent (12), but most point to significantly reduced LSEC endocytic capacity at old age (14,47,54,138).…”

Section: Role Of the Lsec In Age-related Conditionsmentioning

confidence: 99%

The scavenger endothelial cell: a new player in homeostasis and immunity

Sørensen

McCourt

Berg

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

195

258

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To maintain homeostasis, the animal body is equipped with a powerful system to remove circulating waste. This review presents evidence that the scavenger endothelial cell (SEC) is responsible for the clearance of blood-borne waste macromolecules in vertebrates. SECs express pattern-recognition endocytosis receptors (mannose and scavenger receptors), and in mammals, the endocytic Fc gamma-receptor IIb2. This cell type has an endocytic machinery capable of super-efficient uptake and degradation of physiological and foreign waste material, including all major classes of biological macromolecules. In terrestrial vertebrates, most SECs line the wall of the liver sinusoid. In phylogenetically older vertebrates, SECs reside instead in heart, kidney, or gills. SECs, thus, by virtue of their efficient nonphagocytic elimination of physiological and microbial substances, play a critical role in the innate immunity of vertebrates. In major invertebrate phyla, including insects, the same function is carried out by nephrocytes. The concept of a dual-cell principle of waste clearance is introduced to emphasize that professional phagocytes (macrophages in vertebrates; hemocytes in invertebrates) eliminate larger particles (>0.5 μm) by phagocytosis, whereas soluble macromolecules and smaller particles are eliminated efficiently and preferentially by clathrin-mediated endocytosis in nonphagocytic SECs in vertebrates or nephrocytes in invertebrates. Including these cells as important players in immunology and physiology provides an additional basis for understanding host defense and tissue homeostasis.

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“…In the liver, Kupffer cells are responsible for controlling the circulating levels of certain antigens and immune complexes. These cells exhibit an age‐related reduction in the capacity to endocytose and process particulate antigens without the loss of cellular receptors 54,55 . There is some specificity in the age‐dependent decline in the ability of RES cells to endocytose antigens because this function in rat liver endothelial cells, 54 splenic and peritoneal macrophages in the mouse, 56,57 and circulating mononuclear phagocytic cells 58 does not appear to be altered with increasing age.…”

Section: Effects Of Aging On the Gastrointestinal Secretory Immune Symentioning

confidence: 99%

Aging, Gastrointestinal Infections, and Mucosal Immunity

Schmucker¹,

Daniels²

1986

J American Geriatrics Society

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The elderly constitute the fastest growing segment of the population and, as such, pose significant and unique health care problems. Aging is characterized by a decline in the organism's ability to respond or to adapt to a variety of environmental stresses. An example of this reduced “adaptive responsiveness” can be found in the immune system which undergoes a marked and well‐documented decline during aging.1 Perhaps as a result of this deficiency, the incidence of infectious diseases and the associated morbidity and mortality increase significantly in the elderly.2–4 Furthermore, the greater frequency of chronic diseases in the elderly predisposes them to complications resulting from infections.

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Antigen handling in aging II. The role of Kupffer and endothelial cells in antigen processing in fischer 344 rats

Cited by 15 publications

References 22 publications

Old Age and the Hepatic Sinusoid

Old Age and the Hepatic Sinusoid

The scavenger endothelial cell: a new player in homeostasis and immunity

Aging, Gastrointestinal Infections, and Mucosal Immunity

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