Antigen expression on recurrent meningioma cells

Abstract

IntroductionMeningiomas are intracranial brain tumours that frequently recur. Recurrence rates up to 20% in 20 years for benign meningiomas, up to 80% for atypical meningiomas and up to 100% for malignant meningiomas, have been reported. The most important prognostic factors for meningioma recurrence are meningioma grade, meningioma invasiveness and radicality of neurosurgical resection. The aim of our study was to evaluate the differences in antigenic expression on the surface of meningioma cells between recurrent and non-recurrent meningiomas.Methods19 recurrent meningiomas and 35 non-recurrent meningiomas were compared regarding the expression of MIB-1 antigen, progesterone receptors, cathepsin B and cathepsin L, using immunohistochemistry.ResultsMIB-1 antigen expression was higher in the recurrent meningioma group (p=0.001). No difference in progesterone receptor status between recurrent and non-recurrent meningiomas was confirmed. Immunohistochemical intensity scores for cathepsin B (p= 0.007) and cathepsin L (p<0.001) were both higher in the recurrent than in the non-recurrent meningioma group.ConslusionsMIB-1 antigen expression is higher in recurrent compared to non-recurrent meningiomas. There is no difference in expression of progesterone receptors between recurrent and non-recurrent meningiomas. Cathepsins B and L are expressed more in recurrent meningiomas.

Role of progesterone receptor expression and proliferative activity in predicting the recurrence of meningioma

“…Recently, Schiffer et al (2005) It is worth mentioning that the risk of recurrence of meningioma was significantly associated with specific locations, namely, the olfactory groove, sphenoid wing and parasagittal-falcine (Maiuri et al 2007;Vranic, 2010). In this study, tumour recurrence was insignificantly related to tumour location.…”

“…This finding was significant in some reports (Matsuno et al, 1996;Wolfsberger et al, 2004), but insignificant in others (Roser et al, 2004;Korhonen et al, 2006). It was predominant in women in some studies (Leães et al, 2010;Vranic, 2010;Mukherjee et al, 2011) and predominant in men in others (Milenković et al, 2004). PR expression was insignificantly related to sex and this was similar to the studies conducted by Wolfsberger et al (2004), Korhonen et al (2006), Claus et al (2008).…”

“…Meningioma represents 10-20% of primary intracranial tumours (Vranic, 2010). Eighty percent of meningiomas are benign (WHO grade I), whereas almost 20% are atypical (WHO grade II) and 1-2% are anaplastic/malignant (WHO grade III) (Mawrin and Perry, 2010).…”

“…The reported rates of recurrence of grades I, II and III meningioma are 7-25, 29-52 and 50-94%, respectively (Louis et al, 2007). The most important risk factors for recurrence are the histological malignancy grade, invasiveness and thoroughness of surgical resection (Vranic, 2010). The 2007 WHO classification system provides valuable prognostic information (Backer-Grøndahl et al, 2012).…”

“…The 2007 WHO classification system provides valuable prognostic information (Backer-Grøndahl et al, 2012). However, it fails to define the histological criteria to predict recurrence (Vranic, 2010). As a result, alternative approaches are being explored to address this challenge.…”