Antiganglioside antibodies in neurological diseases

Wanleenuwat, Pitchaya; Iwanowski, Piotr; Kozubski, Wojciech

doi:10.1016/j.jns.2019.116576

Cited by 33 publications

(26 citation statements)

References 84 publications

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“…Implications. It is known that impaired vascular structure and function, cerebral hypoperfusion, and atherosclerosis pose risk factors for all forms of dementia (Kalaria, 2016;Wolters et al 2016Wolters et al , 2017Wanleenuwat et al 2019). However, as yet there are no bioassays of intra-or extra-cerebral endothelial function; therefore, development of a means to assess impairments to the cerebrovascular (ICA) endothelium in vivo is crucial.…”

Section: Correlational Analysesmentioning

confidence: 99%

Internal carotid and brachial artery shear‐dependent vasodilator function in young healthy humans

Carr

Hoiland

Caldwell

et al. 2020

The Journal of Physiology

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Brachial artery (BA) shear-mediated dilatation is a widely used assessment of vascular function with links to coronary artery health and cardiovascular risk. r Cerebral vascular health is often interrogated using cerebrovascular (middle cerebral artery velocity) reactivity to carbon dioxide. r We show that endothelium-dependent diameter (dilator) responses are not significantly related between the internal carotid artery (ICA) and BA; nor are endothelium-independent responses. r Additionally, ICA endothelium-dependent responses are not related to middle cerebral artery velocity or ICA blood flow reactivity responses to carbon dioxide. r Therefore, assessment of large extracranial cerebral artery vascular health should be quantified via methods specific to the vessel, not via peripheral endothelial function or cerebrovascular reactivity to carbon dioxide.

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Section: Correlational Analysesmentioning

confidence: 99%

Internal carotid and brachial artery shear‐dependent vasodilator function in young healthy humans

Carr

Hoiland

Caldwell

et al. 2020

The Journal of Physiology

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“…GBS and MFS frequently mimic botulism [24,[135][136][137]. GBS and MFS are immune neuropathies characterized by high titers of serum antibodies against gangliosides, in particular anti-GM1, anti-GD1a, anti-GD1b, anti-GT1b in GBS, and anti-GQ1b in MFS [138][139][140][141][142][143]. The laboratory confirmation of the differential diagnosis between botulism and autoimmune neuropathies is based on the identification of BoNT or antiganglioside antibodies in the patient's sera, respectively.…”

Section: Detection Of Toxin In Sera Of Patients With Neuropathic Sympmentioning

confidence: 99%

Toxemia in Human Naturally Acquired Botulism

Rasetti-Escargueil

Lemichez

Popoff

2020

Toxins

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Human botulism is a severe disease characterized by flaccid paralysis and inhibition of certain gland secretions, notably salivary secretions, caused by inhibition of neurotransmitter release. Naturally acquired botulism occurs in three main forms: food-borne botulism by ingestion of preformed botulinum neurotoxin (BoNT) in food, botulism by intestinal colonization (infant botulism and intestinal toxemia botulism in infants above one year and adults), and wound botulism. A rapid laboratory confirmation of botulism is required for the appropriate management of patients. Detection of BoNT in the patient’s sera is the most direct way to address the diagnosis of botulism. Based on previous published reports, botulinum toxemia was identified in about 70% of food-borne and wound botulism cases, and only in about 28% of infant botulism cases, in which the diagnosis is mainly confirmed from stool sample investigation. The presence of BoNT in serum depends on the BoNT amount ingested with contaminated food or produced locally in the intestine or wound, and the timeframe between serum sampling and disease onset. BoNT levels in patient’s sera are most frequently low, requiring a highly sensitive method of detection. Mouse bioassay is still the most used method of botulism identification from serum samples. However, in vitro methods based on BoNT endopeptidase activity with detection by mass spectrometry or immunoassay have been developed and depending on BoNT type, are more sensitive than the mouse bioassay. These new assays show high specificity for individual BoNT types and allow more accurate differentiation between positive toxin sera from botulism and autoimmune neuropathy patients.

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“…West Nile and Toscana viruses), which were not tested but are endemic in Northern Italy, might be responsible for the present clinical picture [8]. A shortcoming of our report is the lack of antiganglioside antibody testing to identify specific targets of the autoimmune GBS process [9]. Furthermore, we did not perform a complete paraneoplastic/ autoimmune screening in the acute phase including testing for serum onconeural and vasculitis-related antibodies (e.g.…”

mentioning

confidence: 93%