2004
DOI: 10.1590/s1413-86702004000300005
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: Carvacrol and eugenol, the main (phenolic) components of essential oils of some aromatic plants, were evaluated for their therapeutic efficacy in the treatment of experimental oral candidiasis induced by Candida albicans in immunosuppressed rats. This anticandidal activity was analyzed by microbiological and histopathological techniques, and it was compared with that of nystatin, which was used as a positive control. Microbiologically, carvacrol and eugenol significantly (p<0.05) reduced the number of colony f… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

4
69
0
8

Year Published

2010
2010
2022
2022

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 125 publications
(81 citation statements)
references
References 21 publications
4
69
0
8
Order By: Relevance
“…Many EOs show a potent antifungal effect. Chami et al [26] evaluated carvacrol and eugenol, the main components of EOs of some aromatic plants, for their therapeutic efficacy in the treatment of experimental oral candidiasis induced by Candida albicans in immunosuppressed rats. With the help of microbiological and histopathological techniques the authors confirmed the anticandidal activity of the compounds studied.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Many EOs show a potent antifungal effect. Chami et al [26] evaluated carvacrol and eugenol, the main components of EOs of some aromatic plants, for their therapeutic efficacy in the treatment of experimental oral candidiasis induced by Candida albicans in immunosuppressed rats. With the help of microbiological and histopathological techniques the authors confirmed the anticandidal activity of the compounds studied.…”
mentioning
confidence: 99%
“…Pinto et al [28] described similar results studying antifungal activity of the EO of Thymus pulegioides containing high amounts of carvacrol and thymol. The authors found that Combination of carvacrol and 1,8-cineole [25] Carvacrol, eugenol [26] EOs isolated from the aerial parts of some of the Artemisia genus species [27] EO of Thymus pulegioides containing high amounts of carvacrol and thymol [28] EO obtained from Thymus vulgaris L. [29] EOs obtained from aerial parts of aromatic plants such as oregano, thyme, lavender, rosemary, fennel and laurel containing carvacrol, borneol, camphor, anethole and 1,8-cineole [30] Thymol, carvacrol and the mixture of both these pure EOs [31] EO of Schizonepeta tenuifolia containing pulegone, menthone and limonene [32] Thymol, citronellal, eugenol and EO of rosemary [33] EOs isolated from Origanum vulgare L. and Thymus vulgaris L. [34] EOs isolated from traditional medicinal plants (Lippia sidoides, Lippia origanoides, Chenopodium ambrosidoides, Ocidum gratissimum, Justicia pectorals and Vitex agnus-castus) [35] EOs originated from genus Cymbopogon, Eucalyptus and Ocimum [36] the EO examined showed remarkable antifungal activity against clinically relevant fungi (e.g. Candida, Aspergillus) mainly due to lesion formation in the cytoplasmic membrane and a considerable reduction of the ergosterol content.…”
mentioning
confidence: 99%
“…Oral candidosis is a common opportunistic infection among patients with immunological problems or prosthesis users; therefore, it is important to treat this effectively [29]. For the treatment of fungal infections, there are several drugs on the market, such as nystatin and fluconazole; however, with candidosis recurrence in these patients and the frequent use of these drugs, populations of resistant fungi are occurring.…”
Section: Discussionmentioning
confidence: 99%
“…Os glóbulos brancos são responsáveis pelo combate às infecções, sendo que a contagem normal destas células em ratos Wistar fica entre 6.0 e 10.5 x 10 3 mm 3 aproximadamente (Feldman et al, 2000). A leucopenia observada já era esperada devido a imunossupressão provocada nos animais experimentais para o desenvolvimento e manutenção da infecção (CHAMI et al, 2004).…”
Section: Methodsunclassified