Antifungal Resistance of Candida Spp. in Bloodstream Infection

Abstract

BackgroundCandida spp. is a yeast that resides on the skin, in the gastrointestinal tract, urinary tract ... is the cause of opportunistic infection, causes disease in immunocompromised patients, patients treated with medical therapy and invasive surgery includes broadspectrum antibiotics, chemicals and organ transplants [1,2]. Candida spp. can thrive in the intestine, break down the intestinal wall and enter the bloodstream. There are many toxins of Candida in bloodstream infection, which are very dangerous for health and difficult to treat. Fungal infections of the bloodstream include several conditions such as Candida blood infection, endocarditis, meningitis and other forms of deep organ damages. Nearly 96% of fungal infections were caused by Candida spp. [3,4]. Mortality due to Candida has been reported up to 40-50% [5,6]. Candida spp. is the top four causes of sepsis in hospitals, accounting for 9% of the total number of pathogenic microorganisms [7]. In India, according to the study of Vibhor Tak and colleagues, 43% of fatality was caused by fungal infections [2], in the study of Ying-Lien Chena et al, this rate was 40 to 70% [8]. In Vietnam, studies on fungal infections are limited and have not been paid attention like bacterial infections, with little data on antifungal drug resistance. In this study, we investigated the causative agents of antifungal blood infections and the situation of antifungal drug resistance.