Antifungal Resistance in Animal Medicine: Current State and Future Challenges

Álvarez‐Pérez, Sergio; García, Marta E.; Anega, Blanca; Blanco, José Luis Santiago

doi:10.1007/978-3-030-69507-1_10

Cited by 2 publications

(1 citation statement)

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“…Fungi are a kingdom of eukaryotic organisms found throughout the environment. Pathogenic fungi cause fungal infections that impose a substantial burden on the health of humans, animals, and plants [ 1 , 2 , 3 ••, 4 ]. Approximately 1.5–2 million human deaths from fungi occur globally each year [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public Health Problem

Langfeldt

Gold

Chiller

2022

Curr Clin Micro Rpt

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Purpose of Review For this review, we use a One Health approach to examine two globally emerging public health threats related to antifungal drug resistance: triazole-resistant Aspergillus fumigatus infections, which can cause a life-threatening illness in immunocompromised hosts, and antifungal-resistant dermatophytosis, which is an aggressive skin infection caused by dermatophyte molds. We describe the state of current scientific knowledge and outline necessary public health actions to address each issue. Recent Findings Recent evidence has identified the agricultural use of triazole fungicides as an important driver of triazole-resistant A. fumigatus infections. Antifungal-resistant dermatophyte infections are likely driven by the inappropriate use of antifungal drugs and antibacterial and corticosteroid creams. Summary This review highlights the need for a One Health approach to address emerging antifungal resistant infections, emphasizing judicious antifungal use to preserve available treatments; strengthened laboratory capacity to identify antifungal resistance; and improved human, animal, and environmental surveillance to detect emerging resistance, monitor trends, and evaluate the effectiveness of efforts to decrease spread.

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Section: Introductionmentioning

confidence: 99%