Antifungal pulse therapy for onychomycosis. A pharmacokinetic and pharmacodynamic investigation of monthly cycles of 1-week pulse therapy with itraconazole

Clinical and Pharmacokinetic Studies of Continuous Itraconazole for the Treatment of Onychomycosis

“…Total, unchanged‐, and hydroxy‐itraconazole were not detected in nails of patients 1, 2, and 6 of 13 patients at month 1, respectively. The mean concentration of total itraconazole at month 2 was 195.9 ng/g (Table 1), whereas the concentration at month 1 was 51.3 ng/g, which was lower than the MIC of dermatophytes (14, 15). Concentrations of total itraconazole showed more than 400 ng/g at months 3 and 4 following remarkably higher doses of 1,043.1 and 799.4 ng/g at months 5 and 6 (Table 1).…”

Race reporting and representation in onychomycosis clinical trials: A systematic review

“…Of the 302 PubMed initial search results, 182 clinical trials (28,352 participants) met inclusion criteria and were included in the final analysis 6–186 . The PRISMA study selection process is detailed in Figure 1.…”

Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis

“…Thirty‐six studies were included in this meta‐analysis 6–41 . Forty‐seven studies were partially or completely excluded 8,9,12,13,15,16,24,27,32,33,36–38,40,42–74 Figures 1–5. show the cumulative meta‐analytical average of RCTs for mycological cure and clinical response.…”