1996
DOI: 10.1001/archderm.132.1.34
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Antifungal pulse therapy for onychomycosis. A pharmacokinetic and pharmacodynamic investigation of monthly cycles of 1-week pulse therapy with itraconazole

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Cited by 117 publications
(69 citation statements)
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“…De Doncker et al 20 evaluated 2 different intermittent schedules of itraconazole of 3 and 4 months (400 mg/d; 1:4 weeks) and found that the cure rates at 24 weeks were 64% for patients who received the shorter treatment and 72% for those who received 4 months of treatment. 20 The trial had a small number of patients (N = 50), and no significant difference was detected between the treatments. Shemer et al 10 also did not find that a higher longterm cure rate was associated with a 200-mg/d continuous regimen of itraconazole compared with either of the 2 intermittent regimens (1:4 weeks) for 12 or 16 weeks (N=64).…”
Section: Discussionmentioning
confidence: 98%
“…De Doncker et al 20 evaluated 2 different intermittent schedules of itraconazole of 3 and 4 months (400 mg/d; 1:4 weeks) and found that the cure rates at 24 weeks were 64% for patients who received the shorter treatment and 72% for those who received 4 months of treatment. 20 The trial had a small number of patients (N = 50), and no significant difference was detected between the treatments. Shemer et al 10 also did not find that a higher longterm cure rate was associated with a 200-mg/d continuous regimen of itraconazole compared with either of the 2 intermittent regimens (1:4 weeks) for 12 or 16 weeks (N=64).…”
Section: Discussionmentioning
confidence: 98%
“…Itraconazole also has a very long residence time in nails after the cessation of therapy (122). Maximal concentrations of itraconazole in fingernails and toenails are 0.95 g/g and 1.5 g/g, respectively, 4 and 6 months after cessation of pulse therapy (222). The concentration of posaconazole within the human dermis is comparable to that in plasma (59).…”
Section: Skin and Nailsmentioning
confidence: 99%
“…The new systemic antifungals itraconazole and terbinafine have been proven effective and safe by a large number of open and controlled trials [1, 2, 3]. However, there are only a few studies that evaluate the long-term outcome of patients who have been successfully treated [4, 5, 6, 7, 8, 9].…”
Section: Introductionmentioning
confidence: 99%