Antifungal photosensitive activity of Porophyllum obscurum (Spreng.) DC.: Correlation of the chemical composition of the hexane extract with the bioactivity

Effect of drug incorporation technique and polymer combination on the performance of biopolymeric antifungal buccal films

“…An equal volume of the dissolution medium was added after each sample extraction to maintain a constant volume. (Postigo et al, 2017). The agar surface was inoculated by dipping sterile cotton swabs into a cell suspension and by streaking the plate surface in three directions.…”

Recognition of antioxidants and photosensitizers in Dyssodia pinnata by EPR spectroscopy

“…37 This effect is related to the number of hydroxy groups, thus compounds 11 with five hydroxy groups showed the highest activity (50%) compared to quercetin (30%), with four hydroxy groups, even though compound 10, with five hydroxy groups, showed a small 7% reduction probably as a result of the 6-O-methylation. 39 The flavonoids 3-O-glycoside (8 and 12) with the same substitution pattern exhibited similar behaviour with 9 and 10% of reduction, indicating that the loss of planarity between the B and C rings, as a result of the 3-O-glycosidic substitution, weaken reduction, 40 this effect was not observed in quercetagetin-7-O-β-glucoside (11). In all flavonoid and terthiophene derivatives spectra the presence of residual CuSO 4 ·5H 2 O was detected ( Figure 3).…”

“…6 Species of Dyssodia are used in Mexico to cure diarrhoea, stomach ache, and infections, 8 and, in a study to support the utilization of some plants to cure gastrointestinal disorders by the Otomi Indians of Querétaro (México), the chloroform-methanol extract of D. pinnata showed anti-spasmolytic activity, 9 but, to our knowledge, there are no chemical studies of this plant. Herein we report the isolation of terthiophene derivatives (1)(2)(3)(4)(5)(6)(7) and phenolic compounds (8)(9)(10)(11)(12)(13) from the aerial parts of D. pinnata (Figure 1). α-Terthiophene and related compounds (1-7) are known as photosensitizers by their activity against a wide variety of organisms: bacteria, 10 fungi, 11 insects, 12 viruses, 13 and tumour cells, 14 related to their capacity to generate singlet oxygen ( 1 O 2 ) by UV irradiation.…”

“…Herein we report the isolation of terthiophene derivatives (1)(2)(3)(4)(5)(6)(7) and phenolic compounds (8)(9)(10)(11)(12)(13) from the aerial parts of D. pinnata (Figure 1). α-Terthiophene and related compounds (1-7) are known as photosensitizers by their activity against a wide variety of organisms: bacteria, 10 fungi, 11 insects, 12 viruses, 13 and tumour cells, 14 related to their capacity to generate singlet oxygen ( 1 O 2 ) by UV irradiation. 15 Flavonoids (8)(9)(10)(11)(12) have been also extensively studied as antioxidant, anti-inflammatory, 16 and anticarcinogenic agents; 17 among others, and their metal chelating capacity to produce, depending on their substituent pattern, metal complexes with many therapeutic uses has been described.…”

“…α-Terthiophene and related compounds (1-7) are known as photosensitizers by their activity against a wide variety of organisms: bacteria, 10 fungi, 11 insects, 12 viruses, 13 and tumour cells, 14 related to their capacity to generate singlet oxygen ( 1 O 2 ) by UV irradiation. 15 Flavonoids (8)(9)(10)(11)(12) have been also extensively studied as antioxidant, anti-inflammatory, 16 and anticarcinogenic agents; 17 among others, and their metal chelating capacity to produce, depending on their substituent pattern, metal complexes with many therapeutic uses has been described. 18 The earliermentioned properties represent interesting options in photodynamic therapy (PDT) to treat tumours, and infections, but also to prevent free radical damage by the presence of antioxidants and appropriate copper (Cu) chelators.…”