Antifungal Metabolites from the Plant Endophytic Fungus <i>Pestalotiopsis foedan</i>

Ding, Gang; Liu, Shuchun; Guo, Liangdong; Zhou, Yu‐Guang; Che, Yongsheng

doi:10.1021/np070590f

Cited by 134 publications

(98 citation statements)

References 35 publications

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“…However, biology and ecology of most endophytes are not known but are assumed to vary according to host and environment [7,8,38]. A huge number of authors suggested that endophytes are good sources of novel secondary metabolites that possess antibacterial [37,65] antifungal [15,65] and anticancer properties [36]. In this study, the endophytic mycobiota of the medicinal plant Tinospora cordifolia Miers., was studied.…”

Section: Introductionmentioning

confidence: 97%

Season and Tissue Type Affect Fungal Endophyte Communities of the Indian Medicinal Plant Tinospora cordifolia More Strongly than Geographic Location

Mishra

Gond

Kumar³

et al. 2012

Microb Ecol

111

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Section: Introductionmentioning

confidence: 97%

Season and Tissue Type Affect Fungal Endophyte Communities of the Indian Medicinal Plant Tinospora cordifolia More Strongly than Geographic Location

Mishra

Gond

Kumar³

et al. 2012

Microb Ecol

111

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“…(5)(6)(7)(8) Peneciraistin C (Pe-C) ( Fig. 1) is a novel spiroketal compound purified from the fungus Penicillium raistrickii, isolated from saline soil collected in Bohai Bay in Zhanhua (Shandong Province, China).…”

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confidence: 99%

Peneciraistin C induces caspase‐independent autophagic cell death through mitochondrial‐derived reactive oxygen species production in lung cancer cells

et al. 2013

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Peneciraistin C (Pe-C) is a novel spiroketal compound isolated from the saline soil derived fungus Penicillium raistrickii. Our previous study showed that Pe-C exerted a potent cytotoxic effect on many kinds of cancer cell lines, especially on human lung cancer A549 cells. Here, we report the anticancer mechanisms of Pe-C in a variety of lung cancer cells. The results showed that Pe-C induced caspase-independent autophagic cell death and elevated mitochondrial-derived reactive oxygen species levels. Interestingly, if autophagy was blocked by 3-methyladenine or Atg5 siRNA, Pe-C triggered a shift from autophagic cell death into caspase-dependent apoptotic cell death. In addition, cotreatment with the antioxidant N-acetyl-L-cysteine or Mito-TEMPO could effectively reverse the effect of the enhanced reactive oxygen species production, which in turn almost completely prevented the cell death induced by Pe-C. Thus, this study provided new insights into the mechanisms underlying Pe-C-mediated cell death, which indicated that Pe-C could be a potential drug candidate for therapy of lung cancers. (Cancer Sci 2013; 104: 1476-1482 L ung cancer is the leading cause of cancer-related death in men and is second only to breast cancer in women.(1,2) In China, approximately 60 0000 people suffer from this disease and consequently die each year. In clinical practice, lung carcinomas are classified into two major types: non-small-cell lung cancer and small-cell lung cancer.(3) Chemotherapy is still an important option in curing or controlling lung cancer. Although many relatively effective chemotherapeutic agents have been developed, the cure rate of lung cancer is still low because of drug resistance. In addition, the side-effects of chemotherapeutic drugs often hamper the quality of life of lung cancer patients.(4) Therefore, the discovery of effective novel molecular targeted therapies for lung cancer is urgently needed.Spiroketals are cyclic substructures found in many natural products that show a wide range of biological activities, such as antitumor activity, antibacterial activity, and anti-inflammatory effects.(5-8) Peneciraistin C (Pe-C) (Fig. 1) is a novel spiroketal compound purified from the fungus Penicillium raistrickii, isolated from saline soil collected in Bohai Bay in Zhanhua (Shandong Province, China). In preliminary screening, Pe-C showed potent cytotoxic activity in many kinds of human cancer cell lines, especially in human lung cancer A549 cells. (9) In this study, we report the antitumor activity and the possible molecular mechanisms of Pe-C in a variety of lung cancer cells.Over the past decades, apoptosis induction is the main focus in the development of new anticancer drugs, so a great number of studies have been focused on type-I programmed cell death. In contrast, more and more evidence now shows that autophagic cell death has emerged as an important mechanism of cancer cell death induced by anticancer agents.(10-12) The housekeeping role of autophagy is to protect cells under stressful conditions throug...

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“…The NOE (Fig. 2) interaction observed between H a ÀC(6) (d(H) 2.78 (d, J ¼ 16.0)) and HÀC(4), along with no NOE interaction observed between H a ÀC(6) and Me (15) (14) suggested that Me (14) should be b-configurated. Because of some significant signal overlap, we tried to crystallize 1 in different solvents and finally failed to obtain suitable crystals.…”

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confidence: 95%

Eremophilane‐Type Sesquiterpenoids from the Fermentation Broth of Plant Endophytic Fungus Pestalotiopsis photiniae Isolated from the Chinese Podocarpaceae Plant Podocarpus macrophyllus

Yang

Zhang

Zhu

et al. 2011

Helvetica Chimica Acta

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Two new sesquiterpenoid esters, pestalotiopins B and C (1 and 2, resp.) related to the eremophilane class, together with one known compound, berkleasmin C (3), were isolated from the fermentation broth of the plant endophytic fungus Pestalotiopsis photiniae. Their structures and relative configurations were elucidated by extensive spectroscopic analysis including 1D-and 2D-NMR (HSQC, HMBC, and NOESY), and MS experiments. Compound 1 has an interesting lactam structure, and this type of sesquiterpenoid with a lactam structure is reported for the first time.

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Antifungal Metabolites from the Plant Endophytic Fungus Pestalotiopsis foedan

Cited by 134 publications

References 35 publications

Season and Tissue Type Affect Fungal Endophyte Communities of the Indian Medicinal Plant Tinospora cordifolia More Strongly than Geographic Location

Season and Tissue Type Affect Fungal Endophyte Communities of the Indian Medicinal Plant Tinospora cordifolia More Strongly than Geographic Location

Peneciraistin C induces caspase‐independent autophagic cell death through mitochondrial‐derived reactive oxygen species production in lung cancer cells

Eremophilane‐Type Sesquiterpenoids from the Fermentation Broth of Plant Endophytic Fungus Pestalotiopsis photiniae Isolated from the Chinese Podocarpaceae Plant Podocarpus macrophyllus

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