Antifungal Effect of the Extract of the Plants Against Candida albicans

Jahani, Somayeh; Bazi, Saphora; Shahi, Zahra; Asadi, Maryam Sheykhzade; Mosavi, Fahimeh; Baigi, Gelareh Sohil

doi:10.17795/iji-36807

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Clinical isolate of C. albicans from the vagina was also inhibited by harmal compounds at MIC 50 ppm and the level of inhibitory action increased with increased harmal concentration [ 10 ]. The EO of harmal consists of more than 105 chemical compounds that are primarily represented by oxygenated monoterpenes, oxygenated sesquiterpenes and eugenol [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

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Antifungal activity of essential oils against itraconazoleresistant pathogenic Candida isolated from vulvovaginal candidiasis

AL-Janabi

2022

CMM

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Background and Purpose: Fungal infection by species of pathogenic Candida with antifungal resistance is currently a serious problem. Treatment with new medications is becoming more challenging to manage this type of infection. The present study aimed to investigate the antifungal effect of essential oils (EOs) against itraconazole-resistant species of pathogenic Candida. Materials and Methods: Seven essential oils were tested on 15 clinical isolates of itraconazole-resistant Candida from patients with vulvovaginal candidiasis. The antifungal action of selected EOs was evaluated using the disc diffusion method with the determination of the minimum inhibitory concentration (MIC) of effective EOs. Results: Radish EO was the most effective type against all Candida isolates with MICs between 3.125% and 6.25% (v/v) .It also had a stronger effect than itraconazole. Six other EOs showed antifungal effects at varying concentrations and were dependent upon the type of isolate. Low concentrations of these six EOs were more effective against many isolates than their high concentrations. Moreover, camphor and linseed EOs were less effective on isolates. Conclusion: Radish EO has a strong antifungal activity against itraconazole-resistance species of Candida, even more than itraconazole. The antifungal action of some EOs can be increased through the use of low concentrations.

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Section: Resultsmentioning

confidence: 99%

“…Results of these studies showed that the components of the selected plants, other than EO, have antifungal effects against Candida species. Peganum harmala (harmal) seeds, either extracted or not, showed significant inhibitory activity against various species of Candida [ 9 - 10 ].…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of essential oils against itraconazoleresistant pathogenic Candida isolated from vulvovaginal candidiasis

AL-Janabi

2022

CMM

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“…These mainly include Gram‐negative bacteria like Salmonella typhi or Escherichia coli and Gram‐positive bacteria, including Staphylococcus aureus , Listeria monocytogenes and Bacillus cereus (Bintsis, 2017). C. albicans yeasts are commensal microorganisms colonising the skin and mucosal surfaces in healthy individuals, but sometimes they cause infections in humans, especially in immunocompromised patients (Jahani et al ., 2017). Due to the increased resistance of microorganisms to chemotherapeutics, natural substances of plant origin with antimicrobial properties are receiving increasing interest.…”

Section: Discussionmentioning

confidence: 99%

Impact of elicitation and drying methods on biological activities of lovage essential oil

Złotek

Jakubczyk

Rybczyńska‐Tkaczyk

2023

Int J of Food Sci Tech

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Summary The quality of essential oils (EOs) was dependent on the optimised methods of drying. The highest yield of EOs was noted in plants elicited with 0.1% yeast extract (YE) and dried with the traditional method (1.4 mL 100 g dw−1); it was over twice as high as the yield of the control sample (0.58 mL 100 g dw−1). (Z)‐ligustilide, α‐terpinyl acetate and β‐phellandrene were the main compounds identified in the samples. The most effective antioxidant activity was exhibited by the sample obtained from plants elicited with 0.1% YE and subjected to freeze‐drying. The highest RP and LPO inhibition were determined in samples obtained from plants subjected to jasmonic acid (JA) elicitation and freeze‐drying (1.85 and 1.02 μL mL−1 respectively). The use of 0.1% JA and microwave‐drying was the most effective for inhibition of LOXI activity. The highest acetylcholinesterase inhibition was noted in the freeze‐dried sample obtained from plants elicited with YE (86.39 kIU mL−1). The samples exhibited the highest antibacterial activity against L. monocytogenes BBA‐2660.

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“… 40 P. harmala is also used in the form of smoke to kill various parasites like molds and algae as well as various bacterial strains. 41 The aim of current research is to evaluate phytochemical as well as antioxidant and antimicrobial (both antibacterial and antifungal) potential of P. harmala as a potent traditional medicinal plant.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antimicrobial, Phytochemical and FTIR Analysis of Peganum harmala (Fruit) Ethanolic Extract From Cholistan Desert, Pakistan

et al. 2022

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The aim of this study was to evaluate antioxidant and antimicrobial potential of Peganum harmala fruit. Ethanolic extract was prepared and phytochemical screening showed the presence of a lot of chemical compounds. Fourier transform infrared spectroscopy (FTIR) spectra indicated the presence of organic acids, hydroxyl and phenolic compounds, amino groups, aliphatic compounds, and functional groups such as amide, ketone, aldehyde, aromatics, and halogen compounds. Antioxidant activity of the ethanolic extract of P. harmala by the DPPH method showed 71.4% inhibition, whereas IC50 ± SEM (μg/mL) was .406 ± .11. Antibacterial activity was performed against Escherichia coli, Bacillus subtilis, Bacillus pumilus, Micrococcus luteus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Bordetella bronchiseptica. Maximum antibacterial activity was exhibited by Bacillus subtilis (24.33 ± 2 mm) and Bacillus pumilus (23.33 ± 2 mm). Zone of inhibition was 19 ± 2 mm by P. aeruginosa, and it was 18.33 ± 2 mm by Bordetella bronchiseptica. Staphylococcus aureus and Staphylococcus epidermidis had inhibitory effect in the range of 12.33 ± 2 mm and 13.66 ± 3 mm, respectively. 11.66 ± 2 mm and 10 ± 2 mm was zone of inhibition by Micrococcus luteus and E. coli, respectively. Antifungal activity was performed against Aspergillus terreus, Aspergillus fumigatus, Aspergillus flavus and Candida albicans. Ethanolic extract of P. harmala showed antifungal activity against Aspergillus flavus (5 ± 1 mm) and Candida albicans (4 ± 1 mm) . Mild antifungal activity was reported by Aspergillus fumigatus ( 3 ± 1 mm), whereas no activity was exhibited by Aspergillus terreus. Further research is needed in order to evaluate the cytotoxic effects of P. harmala as well.

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Antifungal Effect of the Extract of the Plants Against Candida albicans

Cited by 4 publications

References 15 publications

Antifungal activity of essential oils against itraconazoleresistant pathogenic Candida isolated from vulvovaginal candidiasis

Antifungal activity of essential oils against itraconazoleresistant pathogenic Candida isolated from vulvovaginal candidiasis

Impact of elicitation and drying methods on biological activities of lovage essential oil

Antioxidant, Antimicrobial, Phytochemical and FTIR Analysis of Peganum harmala (Fruit) Ethanolic Extract From Cholistan Desert, Pakistan

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