Antifungal effect of green tea extracts on oral Candida species: An in vitro study

Abstract

Background: Candida is one of the commensals housing the normal oral flora. Oral candidiasis is a common opportunistic infection caused by Candida species (Candida albicans being the most common one). Green tea is well-known for its various health benefits, and the literature reveals ongoing studies on the action mechanisms of green tea extract, in vitro and in vivo. Aims and Objectives: The present study was undertaken to assess antifungal effect of green tea extracts; if proven, could it be used in future as an adjunctive treatment modality for treating candidiasis. Materials and Methods: About 15 healthy volunteers with coated tongue were included for the study. Oral sample, from dorsum of the tongue was collected by commercially available pre-sterilized swabs. The material was inoculated into Sabouraud's Dextrose Agar; confirmed for the presence of Candida species. The sensitivity test was carried out on a lawn culture with 25% and 50% green tea extracts at 24 h and 48 h intervals. The antifungal activity was assessed. Distilled water was used as a control. Student's paired t-test was used to assess the difference in inhibition effect between 25% and 50% of green tea extract solution. Results: Statistically significant increase in the zone of inhibition was noticed at both 25% and 50% concentration of green tea extracts when compared to control group, which did not show any zone of inhibition. Conclusion: Having shown antifungal effects, the green tea extracts may be considered in future as a therapeutic adjunct.

Effect of Mongolian Herbal Tea on Growth of <i>Candida albicans</i>

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In vitro Antifungal Activities of Fluconazole, Camellia sinensis and Cydonia oblonga Leaf Extracts Against Candida Species Isolated from Blood Cultures

“…Previous studies have given positive results on antifungal activity of green tea. According to the results of the studies, in the future the green tea extracts may be considered as a therapeutic adjunct on oral Candida species (10,29,30). In a study, it was demonstrated that green tea was found to be very effective on C. albicans, Streptococcus mutans and Lactobaclli spp (31).…”

Efek Antifungi Sediaan Pasta Gigi Ekstrak Teh Hijau (Camellia sinensis L.) dan Peppermint (Menthapiperita) terhadap Candida albicans

“…Senyawa ini dapat mengganggu integritas membran dan dinding sel serta dapat mengganggu metabolisme sel dengan cara menghambat transpor sel. 11 Berdasarkan penelitian yang dilakukan Madhura et al 12 menyatakan terdapat perbedaan zona hambat yang bermakna pada koloni Candida sp yang diberi ekstrak teh hijau dibandingkan kelompok kontrol. Peningkatan konsentrasi teh hijau diikuti dengan peningkatan luas zona hambat.…”