Antifungal and Antibacterial Activity of Diterpenes Isolated From Wood Extractables of Chilean Podocarpaceae

Becerra, José; Fuentes, César M.; Mena, Juan; Aqueveque, Pedro; Alarcón, Julio; Bittner, M.; Hernández, Vı́ctor; Hoeneisen, M.; Ruíz, Eduardo; Silva, M.

doi:10.4067/s0366-16442002000200011

Cited by 30 publications

(33 citation statements)

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“…Previous chemical studies on Prumnopitys andina reported the isolation of several main compounds belonging to the abietane and pimarane diterpenes (Becerra et al 2002). From the closely related species Podocarpus saligna phenolic diterpenoids (Cambie et al 1984), lignans and norditerpene dilactones (Matlin et al 1984a, b) were reported.…”

Section: Resultsmentioning

confidence: 96%

Secondary metabolites from endophytic fungi isolated from the Chilean gymnosperm Prumnopitys andina (Lleuque)

Schmeda-Hirschmann

Hormazábal

Astudillo

et al. 2005

World J Microbiol Biotechnol

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Schmeda-Hirschmann, G. (reprint author), Hormazabal E, Astudillo L. Laboratorio de Química de Productos Naturales Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla Talca, 747, Chile. Rodriguez J.; Theoduloz, C. Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla Talca, 747, Chile.Two endophytic fungi isolated from the phloem of the Chilean gymnosperm Prumnopitys andinawere cultured in liquid potato-dextrose medium. The secondary metabolites were isolated and identified by spectroscopic methods. The fungus E-3 which could not be identified yielded 4-(2-hydroxyethyl)phenol, p-hydroxybenzaldehyde and the isochromanone mellein. The second fungus, identified as Penicillium janczewskii K.M. Zalessky yielded peniprequinolone and gliovictin, reported for the first time for this species. This is the first report on secondary metabolites produced by endophytic fungi from Chilean gymnosperms

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Section: Resultsmentioning

confidence: 96%

Secondary metabolites from endophytic fungi isolated from the Chilean gymnosperm Prumnopitys andina (Lleuque)

Schmeda-Hirschmann

Hormazábal

Astudillo

et al. 2005

World J Microbiol Biotechnol

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“…The extracts were assessed for antimicrobial activity by the agar diffusion method (Becerra et al 2002) at a concentration of 100 lg/disk against the following microorganisms: Gram-positive bacteria: Bacillus subtilis (ATCC 6633), Micrococcus luteus (ATCC 381), and Staphylococcus aureus (Collection Universidad de Concepción, C. U. de C.); Gram-negative bacteria: Enterobacter dissolvens (LMG 268), Pseudomonas sp. (Collection Universidad de Chile, C. U. C.), and Escherichia coli (C. U. de C.); and fungi: Mucor miehei (Cooney et Emerson Tü 284), Paecilomyces variotii (ETH 44646), and Penicillium notatum (= P. chrysogenum) (Collection University of Kaiserslautern, Germany).…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

“…(Collection Universidad de Chile, C. U. C.), and Escherichia coli (C. U. de C.); and fungi: Mucor miehei (Cooney et Emerson Tü 284), Paecilomyces variotii (ETH 44646), and Penicillium notatum (= P. chrysogenum) (Collection University of Kaiserslautern, Germany). The activity of the extracts was estimated from growth inhibition (in mm) as follows: \8 mm: inactive; 8-12 mm: weak activity; 13-15 mm: moderate activity; [15 mm: strong activity (Becerra et al 2002). As a reference, the commercial antifungals Benlate (benomil: methyl-1-(butylcarbamoyl)-2-benzimidazol carbamate, 50% active ingredient, 50 lg benomil/disk) and chloramphenicol were used as antibacterial standards (30 lg/disk).…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

Endophytic fungi from Chilean native gymnosperms: antimicrobial activity against human and phytopathogenic fungi

Hormazábal

Piontelli

2009

World J Microbiol Biotechnol

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Thirty-eight endophytic fungi were isolated from eight Chilean gymnosperms. Isolates were characterized and grouped according to culture characteristics, colony growth, and conidia morphology. Thirteen isolates were identified: Acremonium bacillisporum, A. bactrocephalum, A. strictum, Alternaria alternata, Aureobasidium pullulans, Chaetomium funicola, Cladosporium tenuissimum, Curvularia protuberata, C. tritici, Microsphaeropsis olivacea, Penicillium chrysogenum, P. janczewskii, and Triblidiopycnis pinastri. Malbranchea and Stegonosporium were identified at the genus level. Fourteen isolates, considered to be sterile mycelia, did not fructify in the culture medium. Crude extracts of liquid cultures from endophytes were examined for antibacterial and antifungal activity against bacteria and phytopathogenic fungi using agar diffusion. Antifungal activity against pathogenic fungi was determined by microdilution assays. Extracts of Acremonium bactrocephalum, Microsphaeropsis olivacea, and isolate E-3 inhibited growth of selected pathogenic organisms, indicating they merit further study. This is the first comparative report on the antimicrobial activity of endophytic fungi from Chilean gymnosperms.

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“…Stapf (Mishra y Dubey, 1994), and Chenopodium ambrosioides L. (Mishra et al, 2002) have demonstrated their strong fungicidal activity. Becerra et al (2002) and Solis et al (2004) have shown antifungal activity of natural terpenes isolated from extractives of Chilean gymnosperm species from the Podocarpaceae and Cupressacea families, respectively.…”

Section: Introductionmentioning

confidence: 99%

Fungistatic Activity Of Essential Oils Extracted from Peumus boldus Mol., Laureliopsis philippiana (Looser) Schodde and Laurelia sempervirens (Ruiz & Pav.) Tul. (Chilean Monimiaceae)

Bittner¹,

Aguilera²,

Hernández³

et al. 2009

Chilean J. Agric. Res.

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Components of essential oils from the Chilean Monimiaceae, boldo (Peumus boldus Mol.), tepa (Laureliopsis philippiana (Looser) Schodde), and laurel (Laurelia sempervirens (Ruiz & Pav.) Tul.) were determined using Gas Chromatography-Mass Spectrometry (GCMS) and fungistatic activity of the essential oils was tested against Rhizoctonia solani Kühn (Donk), Pythium irregulare Buisman, Ceratocystis pilifera (Fr.) C. Moreau, Phragmidium violaceum (Schultz) G. Winter, and Fusarium oxysporum Schltdl. The essential oils of the Monimiaceae species shared some common components; all three had the 3-carene, α-phellandrene, and α-pinene terpenes. L. philippiana and L. sempervirens also had safrole.The main components were ascaridol in P. boldus oil, 3-carene in L. philippiana, and safrole in L. sempervirens. The essential oil from L. sempervirens showed the highest fungistatic activity with significant differences in dose as well as exposure. P. violaceum was the most sensitive strain and P. irregulare the most resistant of all the essential oils (P. boldus extract affected growth by only 19%). Therefore, essential oils from these three plants could be used to control the fungal strains studied.

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Antifungal and Antibacterial Activity of Diterpenes Isolated From Wood Extractables of Chilean Podocarpaceae

Cited by 30 publications

References 0 publications

Secondary metabolites from endophytic fungi isolated from the Chilean gymnosperm Prumnopitys andina (Lleuque)

Secondary metabolites from endophytic fungi isolated from the Chilean gymnosperm Prumnopitys andina (Lleuque)

Endophytic fungi from Chilean native gymnosperms: antimicrobial activity against human and phytopathogenic fungi

Fungistatic Activity Of Essential Oils Extracted from Peumus boldus Mol., Laureliopsis philippiana (Looser) Schodde and Laurelia sempervirens (Ruiz & Pav.) Tul. (Chilean Monimiaceae)

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