Antifungal activity of toothpastes against oral Candida isolates

Yiğit, Nimet; Aktaş, Esin; Ayyıldız, Ahmet

doi:10.1016/j.mycmed.2008.06.003

Cited by 20 publications

(24 citation statements)

References 35 publications

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“…5) had the lowest inhibitory effect on both Candida species, which may be due to the presence of a single ingredient in its formulation. The inhibitory zone diameters observed in our study for the herbal toothpaste with the highest inhibito ry effect range of 23-27 mm were within the range of a toothpaste containing monofluorophosphate (19-36 mm) [9] , but not of another herbal toothpaste (35-50 mm) [10] . These differences in inhibitory effect may be attributed to the ingredients used in the toothpaste formulations as well as to the susceptibility of Candida species used in the aforementioned studies.…”

Section: Discussionsupporting

confidence: 58%

“…The other toothpastes containing non-herbal ingredients ( table 1 ) also elicited anti-Candida activity, most probably due to the antifungal properties documented in some of these ingredients. For instance, it has recently been suggested that triclosan blocks lipid biosynthesis by specifically inhibiting the enzyme enoyl-acyl carrier pro- tein reductase [8,10] . Chlorhexidine suppresses many pathogenic attributes of Candida species [26] .…”

Section: Discussionmentioning

confidence: 99%

“…Chlorhexidine suppresses many pathogenic attributes of Candida species [26] . Fluorides have also demonstrated some antibacterial and antifungal effects such as metabolic interference and reduction of dental plaque acidogenicity [10] . Similar antifungal activity of toothpastes containing triclosan and sodium monofluorophosphate/sodium fluoride on Candida species has previously been reported [8][9][10] .…”

Section: Discussionmentioning

confidence: 99%

“…Despite the wide spectrum of antibacterial activity of different toothpaste formulations [8] , information on their antifungal properties is scarce [9,10] , and none of these studies have determined the anti-candidal activity of toothpastes on C. dubliniensis isolates. Hence, we investigated the antiCandida activity on oral as well as nonoral C. albicans and C. dubliniensis isolates of 2 toothpastes consisting of herbal extracts and compared these 2 with 7 other brands of toothpastes commonly used in Kuwait.…”

Section: Introductionmentioning

confidence: 99%

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A Comparison of the Antifungal Activity of Herbal Toothpastes against Other Brands of Toothpastes on Clinical Isolates of Candida albicans and Candida dubliniensis

et al. 2011

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Objectives: To evaluate the anti-Candida activity on Candida albicans and Candida dubliniensis species of 2 herbal and 7 other brands of toothpastes commonly used in Kuwait. Materials and Methods: Antifungal activity was determined by agar diffusion test on 65 isolates of C. albicans and 21 isolates of C. dubliniensis for each toothpaste. A uniform quantity of toothpaste was filled into wells punched into Sabouraud dextrose agar medium plates inoculated with the test isolates, incubated at 37°C; inhibition zone diameters were read after 24 h. Results: The mean inhibition zone diameters ranged between 12 and 23 mm for C. albicans and between 12 and 27 mm for C. dubliniensis. A herbal toothpaste brand manufactured in the Middle Eastern region (United Arab Emirates) consisting of many herbal ingredients compared to other brands was found to be the most active (p < 0.001) against both Candida species tested, which also demonstrated higher inhibitory activity against C. dubliniensis isolates compared to C. albicans.Conclusions: The herbal toothpaste brand presented significant anticandidal activity over conventional toothpastes and may be useful in reducing the pathogenic potential of Candida species.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Comparison of the Antifungal Activity of Herbal Toothpastes against Other Brands of Toothpastes on Clinical Isolates of Candida albicans and Candida dubliniensis

et al. 2011

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“…Yigit et al 28 avaliaram o efeito de cremes dentais frente a espécies de Candida e observaram boa atividade, assim como Abirami, Venugopal 29 e Adwan et al 30 .…”

Section: Pesquisa De Patógenosunclassified

Análise da contaminação microbiológica de diferentes dentifrícios

Oliveira

Rossato

Bertol

2016

Rev. odontol. UNESP

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ResumoIntrodução: A avaliação microbiológica em produtos de higiene pessoal constitui uma etapa importante no que se refere à segurança do usuário e à qualidade do produto, visto que a carga microbiana elevada pode acarretar problemas de saúde, especialmente em pessoas imunocomprometidas. Objetivo: Verificar o cumprimento das exigências acerca da qualidade microbiológica de cremes e géis dentais adquiridos comercialmente. Material e método: Realizou-se a contagem de bactérias e fungos viáveis totais e pesquisa dos patógenos E. coli, Salmonella sp., S. aureus e P. aeruginosa em 21 amostras. Resultado: Das amostras analisadas, 52,0% apresentaram crescimento microbiano e 28,6% e 0,21% apresentaram contaminação fúngica e bacteriana, respectivamente, acima dos limites descritos na Farmacopeia Brasileira para preparações de uso tópico (máximo permitido 2 × 10 2 UFC/g de bactérias e 2 × 10 1 UFC/g de fungos). Nenhuma amostra apresentou os patógenos pesquisados E. coli, Salmonella sp., S. aureus e P. aeruginosa. Conclusão: Estes resultados indicam que muitos produtos disponíveis no mercado apresentam qualidade inadequada, demonstrando falhas no controle de qualidade. Para prevenir esta situação, faz-se necessária fiscalização rigorosa e adoção de medidas regulamentadoras e educacionais aliadas ao seguimento das Boas Práticas de Fabricação pelas indústrias fabricantes.Descritores: Contaminação microbiológica; controle de qualidade; cremes dentais; géis dentais. AbstractIntroduction: Microbiological evaluation in personal care products is important to guarantee user safety and product quality since microbial contamination elicits health problems especially in immunocompromised patients. Objective: To verify the compliance with the requirements regarding the microbiological quality of creams and dental gels acquired commercially. Material and method: Microbiological contamination was performed through total bacterial and fungal viable count and research of E. coli, Salmonella sp., S. aureus and P. aeruginosa in twenty-one samples. Result: 52.0% of sample presented microbial growth, and 28.6% and 0.21% presented fungal and bacterial contamination, respectively, exceeding the limits described in Brazilian Pharmacopoeia for topical preparations (maximum allowable 2 × 10 2 CFU / g of bacteria and 2 × 10 1 CFU / g yeast). None of the researched pathogens E. coli, Salmonella sp., S. aureus and P. aeruginosa were found. Conclusion: These results indicate that many products available in the market present inadequate quality, demonstrating quality control failures. Rigorous inspection and adoption of regulatory and educational measures aligned with the compliance of Good Manufacturing Practices by manufactures are needed to prevent this situation.

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Triclosan

Kampf

2018

Antiseptic Stewardship

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Antifungal activity of toothpastes against oral Candida isolates

Cited by 20 publications

References 35 publications

A Comparison of the Antifungal Activity of Herbal Toothpastes against Other Brands of Toothpastes on Clinical Isolates of<i> Candida albicans</i> and <i>Candida dubliniensis</i>

A Comparison of the Antifungal Activity of Herbal Toothpastes against Other Brands of Toothpastes on Clinical Isolates of<i> Candida albicans</i> and <i>Candida dubliniensis</i>

Análise da contaminação microbiológica de diferentes dentifrícios

Triclosan

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