Antifungal activity of silver nanoparticles against Candida spp.

Panáček, Aleš; Kolář, Milan; Večeřová, Renata; Prucek, Robert; Soukupová, Jana; Kryštof, Vladimı́r; Hamal, Petr; Zbořil, Radek; Kvı́tek, Libor

doi:10.1016/j.biomaterials.2009.07.065

Cited by 855 publications

(494 citation statements)

References 38 publications

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“…This was also visualized with the presence of cotton-like formations in all tests tubes of the twofold dilutions which were most pronounced after 72 h of the experiment. The observed difference in the minimal bactericidal and fungicidal concentrations of the silver nanoparticles is probably derived from the different structures of bacterial and yeast cell since the eukaryotic organisms posses better organized cell structure [29].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and comparative study on the antimicrobial activity of hybrid materials based on silver nanoparticles (AgNps) stabilized by polyvinylpyrrolidone (PVP)

et al. 2011

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Hybrid materials based on polyvinylpyrrolidone (PVP) with silver nanoparticles (AgNps) were synthesized applying two different strategies based on thermal or chemical reduction of silver ions to silver nanoparticles using PVP as a stabilizer. The formation of spherical silver nanoparticles with diameter ranging from 9 to 16 nm was confirmed by TEM analysis. UV-vis and FTIR spectroscopy were also applied to confirm the successful formation of AgNps. The antibacterial activity of the synthesized AgNPs/PVP against etalon strains of three different groups of bacteria-Staphylococcus aureus (S. aureus; grampositive bacteria), Escherichia coli (E. coli; gram-negative bacteria), Pseudomonas aeruginosa (P. aeruginosa; nonferment gram-negative bacteria), as well as against spores of Bacillus subtilis (B. subtilis) was studied. AgNps/PVP were tested for the presence of fungicidal activity against different yeasts and mold such as Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, and Aspergillus brasiliensis. The hybrid materials showed a strong antimicrobial effect against the tested bacterial and fungal strains and therefore have potential applications in biotechnology and biomedical science.

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Section: Resultsmentioning

confidence: 99%

Synthesis and comparative study on the antimicrobial activity of hybrid materials based on silver nanoparticles (AgNps) stabilized by polyvinylpyrrolidone (PVP)

et al. 2011

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“…AgNPs and AuNPs are the most commonly used nanotechnology and have numerous applications in medical healthcare. They have various biological properties, including anti-microbial (Panácek et al, 2009;Alarcon et al, 2012), anti-inflammatory (Wong et al, 2009), and antiangiogenesis properties (Arvizo et al, 2011). AgNPs and AuNPs upregulate the expression of the proinflammatory genes interlukin-1 (IL-1), interlukin-6 (IL-6), and tumor necrosis factor (TNF-α) in macrophage cells (Yen et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-α production via MAPK pathway in leukemic cell lines

Parnsamut¹,

Brimson²

2015

Genet. Mol. Res.

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“…The possible mechanisms of antifungal action of nanoparticles are cell membrane disruption, cell division inhibition, and cell wall formation inhibition. Fungal cell wall is composed of ergosterol, the silver nanoparticles disrupt the cell membrane by inhibiting ergosterol synthesis or binding with sterol, forming pits and causing the membrane permeability to become leaky leads to cell death [19,20]. Silver nanoparticles may affect the mitotic spindle cell division by targeting the microtubule and also inhibit DNA transcription [21].…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Characterization of Silver Nanoparticles From Marine Brown Seaweed and Its Antifungal Efficiency Against Clinical Fungal Pathogens

Rajeshkumar¹,

Malarkodi²,

S³

2017

Asian J Pharm Clin Res

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Objectives: The aim of this study is to synthesize silver nanoparticles using the algal extract of Padina tetrastromatica and evaluate its antifungal activity against pathogenic fungus isolated from clinical samples.Methods: Dried algal biomass was used to prepare the pure algal extract and added with 1 mM AgNO 3 , and the color change was noted and recorded by ultraviolet (UV)-vis spectrophotometer. The morphological characteristics were analyzed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Crystalline structure was analyzed by SAED pattern. Antifungal activity was performed by agar well diffusion method against various pathogenic fungi.Results: Formation of brown color at 15 minutes indicates the production of silver nanoparticles by the extract of brown algae P. tetrastromatica. Surface plasmon resonance band was centered at 440 nm which was observed by UV-vis spectrophotometer. SEM image revealed spherical and cubical nanoparticles with high agglomeration, and energy-dispersive X-ray illustrates elemental components of silver formed at 3 keV. TEM shows spherical, truncated, and ellipsoidal nanoparticles and also it evidences the algae compounds that are capped with nanoparticles. SAED pattern proved four diffraction face-centered cubic rings at (111), (200), (220), and (311) which indicates the crystalline nature of nanoparticles. Silver nanoparticles show high inhibition activity against Fusarium sp, Aspergillus niger, Candida albicans, Aspergillus fumigatus, and Aspergillus flavus at different concentrations. P. tetrastromatica-mediated synthesis of silver nanoparticles shows rapid and eco-friendly silver ion reduction process. Conclusion:Therefore, this present study elucidates that algae-mediated synthesized silver nanoparticles have antifungal activity against pathogenic fungi, so it can be developed as a novel medicine for human welfare in biomedical applications in the near future.

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Antifungal activity of silver nanoparticles against Candida spp.

Cited by 855 publications

References 38 publications

Synthesis and comparative study on the antimicrobial activity of hybrid materials based on silver nanoparticles (AgNps) stabilized by polyvinylpyrrolidone (PVP)

Synthesis and comparative study on the antimicrobial activity of hybrid materials based on silver nanoparticles (AgNps) stabilized by polyvinylpyrrolidone (PVP)

Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-α production via MAPK pathway in leukemic cell lines

Synthesis and Characterization of Silver Nanoparticles From Marine Brown Seaweed and Its Antifungal Efficiency Against Clinical Fungal Pathogens

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