Antifungal Activity of Eugenol Loaded Electrospun PAN Nanofiber Mats Against Candida Albicans

Semnani, Koroush; Shams-Ghahfarokhi, Masoomeh; Afrashi, Mehran; Fakhrali, Aref; Semnani, Dariush

doi:10.2174/1567201815666180226120436

Cited by 26 publications

(15 citation statements)

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“…This slow release is beneficial as PAN nanofiber will retain the bioactive agent throughout their useful life. Similar results were obtained with other drugs loaded into PAN nanofibers [33].…”

Section: The Release Profile Of Dlf In Ptmsupporting

confidence: 88%

“…The side effects of oral administration of drugs have led us to investigate the possibility of encapsulating DLF in a polymeric drug delivery system based on PAN nanofibers which can be produced cheaply and having high applicability to be employed for transdermal delivery of drugs on the wound site. Besides, the polymer selection was based upon the high drug loading capacity, good mechanical strength, and prolong release characteristics [33]. The present work describes the preparation of antibacterial DLF loaded nanofibers using PAN as the filament-forming matrix, aimed for transdermal delivery.…”

Section: Introductionmentioning

confidence: 99%

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Evaluating Antibacterial Efficacy and Biocompatibility of PAN Nanofibers Loaded with Diclofenac Sodium Salt

et al. 2021

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Side effects of the drugs’ oral administration led us to examine the possibility of using diclofenac sodium (DLF) in a polymeric drug delivery system based on electrospun polyacrylonitrile (PAN) nanofibers, which can be produced cost-effectively and with good applicability for transdermal treatments. The inclusion of DLF in PAN nanofibers increased the nanofiber diameter from ~200 nm to ~500 nm. This increase can be attributed to the increase in the spinning solution viscosity. FTIR spectra confirm the entrapment of the DLF into the PAN nanofibers. X-ray diffraction pattern showed that the inclusion of the DLF in the PAN nanofibers had caused the misalignment in the polymeric chains of the PAN, thus resulting in a decrease of the peak intensity at 2θ = 17o. The DLF loaded PAN nanofibers were efficient against the gram-positive Staphylococcus aureus (S. aureus) and gram-negative Escherichia coli (E. coli), with maximum inhibition zone of 16 ± 0.46 mm for E. coli and 15.5 ± 0.28 mm for S. aureus. Good cell viability ~95% for L929 cells in more extended incubation periods was reported. A gradual release of DLF from the PAN nanofiber was observed and can be attributed to the stability of Pan in PBS medium. Cell adhesion micrographs show that cell-cell interaction is stronger than the cell-material interaction. This type of weak cell interaction with the wound dressing is particularly advantageous, as this will not disturb the wound surface during the nursing of the wound.

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Section: The Release Profile Of Dlf In Ptmsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Evaluating Antibacterial Efficacy and Biocompatibility of PAN Nanofibers Loaded with Diclofenac Sodium Salt

et al. 2021

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“…Blending PAN with cellulose acetate can be used to increase the absorption properties of activated carbon nanofi bres [52]. PAN/gelatine blends can be used for the promotion of cell growth ( Figure 2) [53][54][55].…”

Section: Electrospinnable Polymer Materials For Wound Dressing Applicmentioning

confidence: 99%

Review of Possible Applications of Nanofibrous Mats for Wound Dressings

Mamun¹

2019

TEK

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Skin is an important part of the human body. Its function is to control the body's homeostasis mechanism. If a skin injury occurs, it is of utmost importance to heal the skin as soon as possible. The currently available medical treatment system, however, has limited eff ectiveness on the regeneration of the structure and function of the injured skin, potentially causing wound infections and dehydration. The corresponding impact on the healing process may in the worst case also be fatal. To overcome these problems in wound dressing materials, nanofi brous mats are excellent candidates for wound treatment and management. Such wound dressings can be found in biomedical applications not only in drug delivery, but also as antibacterial and antimicrobial materials, and as materials for the regeneration and repair of tissue or organs. The large surface-area-to-volume ratio is one of the unique properties of nanofi brous mats. This paper gives a brief overview of possible materials and applications of nanofi brous mats for wound dressing.

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“…Preserving, storing, and maintaining the biologically active materials in the ber offer various advantages in the agricultural research. Encapsulation of bacteria in electrospun PVA nano bre extended the shelf life period and survivability for three months without further loss (Semnani et al 2018). Damasceno et al (2013) demonstrated the successful rhizobial encapsulation in PVA electrospun nano bre to protect the microbes and increase the shelf-life besides improved germination, seedling emergence, number of root nodules, plant biomass and growth in soybean seeds invigorated with rhizobium loaded nano bres.…”

Section: Introductionmentioning

confidence: 99%

Immobilization of beneficial microbe Methylobacterium aminovorans in electrospun nanofibre as potential seed coatings for improving germination and growth of groundnut Arachis hypogaea

et al. 2021

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Seed inoculation with microbial cells is one of the potential invigouration techniques for enhancing the emergence and growth of plants. Herein, we approached a new localized delivery of bene cial microbial cells (Methylobacterium) by invigorating seeds with electrospun Polyvinyl alcohol (PVA) nano bre contains microbial cells. Methylobacterium is a growth promoting bacteria recently draws attention in agriculture particularly for drought management. PVA was used in this research because of its electrospinnability and biodegradability. Encapsulation study shows effective immobilization of bacteria cells (Methylorubrum aminovorans) in PVA nano bre, and SEM and TEM characterization further con rmed the entrapment of microbial cells. The microbial plating enumeration reveals 6.6 x 10 5 CFU g − 1 of nano bre to the initial loading population of 1 × 10 8 CFU. Viability of nano bre encapsulated bacterial cells under ambient environment found 1.85 × 10 5 CFU g − 1 , 2.2 × 10 4 CFU g − 1 and 1.2 × 10 4 CFU g − 1 on 10, 20 and 30 days after storage. In vitro bio-e cacy study exhibits that the seeds coated by PVA nano bres containing M. aminovorans recorded higher germination, root & shoot length, seedling vigour, drymatter production, plant biomass, plant root volume, nodule numbers and fresh weight of nodules. The data of this study concludes that microbial cells could be immobilized in electrospun nano bre for extended shelf-life of microbial cells and as effective seed coating for localized delivery.

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Antifungal Activity of Eugenol Loaded Electrospun PAN Nanofiber Mats Against Candida Albicans

Abstract: According to the results, these nanofiber mats loaded with eugenol can be used for treating cutaneous mucocutaneous candidiasis in high risk patients as a coating on a fabric substrate or temporary wound dressing.

Cited by 26 publications

References 0 publications

Evaluating Antibacterial Efficacy and Biocompatibility of PAN Nanofibers Loaded with Diclofenac Sodium Salt

Evaluating Antibacterial Efficacy and Biocompatibility of PAN Nanofibers Loaded with Diclofenac Sodium Salt

Review of Possible Applications of Nanofibrous Mats for Wound Dressings

Immobilization of beneficial microbe Methylobacterium aminovorans in electrospun nanofibre as potential seed coatings for improving germination and growth of groundnut Arachis hypogaea

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