Antifungal activity of alpha-mangostin against Candida albicans

Abstract

This study was conducted to examine the activity of alpha-mangostin against Candida albicans, the most important microorganism implicated in oral candidiasis. Its activity was compared to Clotrimazole and Nystatin. Results showed that alphamangostin was effective against C. albicans, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 1,000 and 2,000 µg/ml, respectively. The C. albicans killing activity of alpha-mangostin was more effective than Clotrimazole and Nystatin. The cytotoxicity of alphamangostin was determined and it was found that alphamangostin at 4,000 µg/ml was not toxic to human gingival fibroblast for 480 min. The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis. (J Oral Sci 51, [401][402][403][404][405][406] 2009)

Inhibitory Effect ofCratoxylum formosumGum onCandida glabrataand Itsα-mangostin Content

“…This study also focused on the quantification of α-mangostin and it was revealed that the amount of this xanthone derivative present in the gum was 4.08% w/w. Compared with that demonstrated by Kaomongkolgit et al [17], the yield of α-mangostin from the dried pericarp of mangosteens (Garcinia mangostana) was approximately 10 times (0.4% w/w) less than that from C. formosum.…”

“…were traditionally employed for painting in the oral cavity [8,9,15]. Many studies have shown α-mangostin to exert the most potent antimicrobial activity against both bacteria and fungi, among all the xanthone compounds [16,17]. This study also focused on the quantification of α-mangostin and it was revealed that the amount of this xanthone derivative present in the gum was 4.08% w/w.…”

Antitumorigenicity of xanthones-rich extract from Garcinia mangostana fruit rinds on HCT 116 human colorectal carcinoma cells

“…α-mangostin was the first xanthone isolated from G. mangostana and several other xanthones were isolated as well (Pedraza-Chaverri et al, 2008). Previous studies on different xanthones demonstrated remarkable pharmacological activities including analgesic (Cui et al, 2010), antioxidant (Jung et al, 2006), antiinflammatory Tewtrakul et al, 2009), anticancer (Akao et al, 2008;Doi et al, 2009;Hung et al, 2009;Matsumoto et al, 2004), antiallergy (Nakatani et al, 2002), antibacterial (Chomnawang et al, 2009;Sakagami et al, 2005), antituberculosis (Suksamrarn et al, 2003), antifungal (Kaomongkolgit et al, 2009) and antiviral (Chen et al, 1996).…”

Screening of mammalian DNA polymerase and topoisomerase inhibitors from Garcinia mangostana L. and analysis of human cancer cell proliferation and apoptosis

“…The xanthones from mangosteen are gaining more interest because of their remarkable pharmacological effects, including not only anticancer activities (14,15), but also analgesic (16), antioxidant (17), anti-inflammatory (18), anti-allergy (19), antibacterial (20), anti-tuberculosis (21), antifungal (22), antiviral (23), cardioprotective (24), neuroprotective (25) and immunomodulation (26) effects. However, the underlying molecular mechanisms of these compounds and their effects on the activities of DNA metabolic enzymes have not been reported.…”