Inhibitory Effect ofCratoxylum formosumGum onCandida glabrataand Itsα-mangostin Content

Abstract

Abstract. Candida glabrata is the most common fungal species isolated in patients with severe mucosal inflammation. The high resistance to traditional antifungal therapies makes this species a growing concern in clinical settings. Cratoxylum formosum is a plant widely distributed in mountainous area of Asian countries. This study aims to examine antifungal activity of C.formosum gum against C.glabrata and its α-mangostin content. Inhibition of fungal growth was primarily tested by agar diffusion. Broth dilution method was then used to determine the minimum inhibitory concentration (MIC). The D-mangostin content was determined by high performance liquid chromatography (HPLC). Inhibitory effect of the gum was seen against C.glabrata (clinical isolate and ATCC22019) with zones of inhibition ranging from 14.3 to 10.2 mm. MIC value against C. glabrata ATCC22019 and the clinical isolate was 1.25 mg/mL. By HPLC, the D-mangostin content of C.formosum gum was determined as 4.08% (w/w). In conclusion, the anticandidal activity of C.formosum gum suggests that this plant may be a useful source for the development of a novel antifungal agent against candidal infection. Further in vitro/in vivo studies should be conducted to understand the mechanisms of action and to establish the safe profile of this gum for clinical usage..

The metabolic and molecular mechanisms of α‑mangostin in cardiometabolic disorders (Review)

“…Yongpitakwattana et al (130) observed that the inhibitory effects of α-mangostin (25 µM) on the expression levels of the genes, TNF-α, ccL4, ccL5, cXcL10 and IFN-α, gene involved in the vascular leakage and immunopathogenesis of dENV2-infected immature monocyte-derived dendritic cells were significantly reduced. However, it was noted that the levels of the anti-inflammatory cytokine, IL-10, were also reduced in that study, contrary to other studies reporting an increase in the levels of this cytokine following α-mangostin treatment (20,126).…”

“…1), and one of the significant phytochemical constituents in the tropical fruit Garcinia mangostana (11)(12)(13). It has also been found in other Garcinia (G.) species, including G. dulcis (14), G. staudtii (15) G. merguensis (16) and G. cowa (17), and in the perennial tropical trees Cratoxylum cochinchinense (18), Cratoxylum arborescens (19), Cratoxylum formosum (20) and Pentadesma butyracea (21). In G. mangostana, α-mangostin is mainly found in the fruit pericarp (12,22) which has been traditionally used to treat several health conditions, including abdominal pain, diarrhea, dysentery, wound infections, suppuration, and chronic ulcers (23).…”