Antifungal activity of acetone extracts from Punica granatum L. , Quercus suber L. and Vicia faba L.

Akroum, S.

doi:10.1016/j.mycmed.2016.10.004

Cited by 26 publications

(15 citation statements)

References 22 publications

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“…Hydro-methanolic extracts of leaves from Juglans regia and Eucalyptus globulus and methanol extract of Cynomorium coccineum demonstrated excellent antimycotic property against Candida strains [91,97]. Akroum [98] showed antifungal activity in an acetylic extract of Vicia faba against C. albicans in vitro and reduced mortality rates in Candida-infected mice that were treated with the extract.…”

Section: Medicinal Plants As a Source Of Antifungal Agentsmentioning

confidence: 99%

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Monteiro¹,

Santos²

2020

Phytochemicals in Human Health

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The rate of fungal infections is increasing rapidly, and pathogenesis of their species is poorly understood. Among fungi, Candida species are a major cause of morbidity and mortality worldwide and thus represent a serious threat to public health. In addition, Cryptococcus spp. are yeasts responsible for serious lung infections and meningitis. Polyenes, fluoropyrimidines, echinocandins, and azoles are used as commercial antifungal agents to treat fungal infections. However, the presence of intrinsic and developed resistance against azole antifungals has been extensively documented. The re-emergence of classical fungal diseases has occurred because of the increment of the antifungal resistance phenomenon. In this way, the development of new satisfactory therapy for fungal diseases persists as a major challenge of present-day medicine. The urgent need includes the development of alternative drugs that are more efficient and tolerant than those traditional already in use. The identification of new substances with potential antifungal effect at low concentrations or in combination is also a possibility. This chapter briefly examines the infections caused by Candida and Cryptococcus species and focuses on describing some of the promising alternative molecules and/or substances that could be used as antifungal agents, their mechanisms of action, and their use in combination with traditional drugs.

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Section: Medicinal Plants As a Source Of Antifungal Agentsmentioning

confidence: 99%

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Monteiro¹,

Santos²

2020

Phytochemicals in Human Health

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“… Akroum (2017) showed antifungal activity in an acetylic extract of Vicia faba against C. albicans (MIC of 0.010 mg/mL) in vitro . Further, mortality rates were reduced in mice that were administered with the extract (20 μg/mL) for treatment of candidiasis.…”

Section: Peptides As Antifungal Agentsmentioning

confidence: 99%

Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

et al. 2018

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The Candida genus comprises opportunistic fungi that can become pathogenic when the immune system of the host fails. Candida albicans is the most important and prevalent species. Polyenes, fluoropyrimidines, echinocandins, and azoles are used as commercial antifungal agents to treat candidiasis. However, the presence of intrinsic and developed resistance against azole antifungals has been extensively documented among several Candida species. The advent of original and re-emergence of classical fungal diseases have occurred as a consequence of the development of the antifungal resistance phenomenon. In this way, the development of new satisfactory therapy for fungal diseases persists as a major challenge of present-day medicine. The design of original drugs from traditional medicines provides new promises in the modern clinic. The urgent need includes the development of alternative drugs that are more efficient and tolerant than those traditional already in use. The identification of new substances with potential antifungal effect at low concentrations or in combination is also a possibility. The present review briefly examines the infections caused by Candida species and focuses on the mechanisms of action associated with the traditional agents used to treat those infections, as well as the current understanding of the molecular basis of resistance development in these fungal species. In addition, this review describes some of the promising alternative molecules and/or substances that could be used as anticandidal agents, their mechanisms of action, and their use in combination with traditional drugs.

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“…Tables 2 and 3 were used to organize the information gained from each study [11][12][13][14][15][16][17][18][19]. Table 2 displays data from combined in vivo/in vitro studies whilst Table 3 contains information from in vitro studies only .…”

Section: Data Extractionmentioning

confidence: 99%

Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review

Hsu

Sheth

Veses

2021

MRMC

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Background: In the era of antimicrobial resistance, fungal pathogens are not an exception. Several strategies, including antimicrobial stewardship programs and high throughput screening of new drugs are being implemented. Several recent studies have demonstrated effectiveness of plant compounds with antifungal activity. Objective: In this systematic review we examine the use of natural compounds as a possible avenue to fight fungal infections produced by Candida albicans, the most common human fungal pathogen. Method: Electronic literature searches were conducted through PubMed/MEDLINE, Cochrane, and Science Direct limited to the 5 years. A total of 131 articles were included with 186 plants extracts evaluated. Results: Although the majority of the natural extracts exhibited antifungal activities against C. albicans (both in vivo and in vitro), the strongest antifungal activity was obtained from Lawsonia inermis, Pelargonium graveolens, Camellia sinensis, Mentha piperita, and Citrus latifolia. Conclusion: The main components with proven antifungal activities were phenolic compounds such as gallic acid, thymol, and flavonoids (specially catechin), polyphenols such as tannins, terpenoids and saponins. The incorporation of nanotechnology enhances greatly the antifungal properties of these natural compounds. Further research is needed to fully characterize the composition of all herbal extracts with antifungal activity as well as the mechanisms of action of the active compounds.

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Antifungal activity of acetone extracts from Punica granatum L. , Quercus suber L. and Vicia faba L.

Cited by 26 publications

References 22 publications

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review

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