Antifungal activities of polyhexamethylene biguanide and polyhexamethylene guanide against the citrus sour rot pathogen Geotrichum citri-aurantii in vitro and in vivo

Feng, Lei; Wu, Fangming; Li, Jing; Jiang, Yueming; Duan, Xuewu

doi:10.1016/j.postharvbio.2011.03.002

Cited by 73 publications

(51 citation statements)

References 12 publications

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“…Despite a significant body of literature related to guanidine‐containing polymers,14–21 vibrational spectroscopic characterization of PHMG is absent. So, the Raman spectrum of the newly synthesized biocide is presented here.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, there is a need for efficient antimicrobial additives compatible with PA resins that have good thermal stability and are able to be used under moulding conditions. Recent studies14–16 have shown that poly(hexamethylene guanidine) (PHMG) salts exhibit a very wide range of biocidal activity against bacteria and fungi. The biocidal properties of PHMG are related to the presence of guanidine groups 17, 18.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of new antifungal polyamide-12 material

Rogalsky¹,

Bardeau

Tarasyuk³

et al. 2012

Polym. Int.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication of new antifungal polyamide-12 material

Rogalsky¹,

Bardeau

Tarasyuk³

et al. 2012

Polym. Int.

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“…Imazalil and Thiabendazole) registered for use on citrus fruit (Brown and Miller 1999;Liu et al 2009). The disease can be partially reduced by sodium o-phenyl phenate (Rippon and Morris 1981;Feng et al 2011), careful harvesting and handling of fruit, and by low-temperature storage (Eckert and Brown 1988). In most commercial packing houses in the SMD Valley, pre-storage chemical control with guazatine is commonly applied as postharvest drench to reduce the incidence of sour rot in citrus fruit that is stored in cold before processing or before degreening operations.…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of Moroccan medicinal plants against citrus sour rot agent Geotrichum candidum

Talibi

Askarne

Boubaker

et al. 2012

Letters in Applied Microbiology

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Aims: The aim of this work was to find an alternative to the chemical fungicides currently used in the control of Geotrichum candidum, the causal agent of citrus sour rot. Methods and Results: Minimal inhibition concentrations (MIC) and minimal fungicidal concentrations (MFC) were determined using agar dilution method. The methanol extracts of Cistus villosus, Ceratonia siliqua and Halimium umbellatum exhibited strong antifungal activity with MIC values ranged between 0·156 and 1·25 mg ml−1, and MFC values ranged between 2·5 and 5 mg ml−1. Incidence of sour rot was lowered to 0·00, 3·33 and 11·66% when mandarin fruit was treated with C. villosus, C. siliqua and H. umbellatum methanol extracts at 50 mg ml−1, respectively, compared with 95% in the control. Conclusions: Cistus villosus, C. siliqua and H. umbellatum methanol extracts successfully reduced the disease incidence caused by G. candidum, and no phytotoxic effects were recorded on citrus fruit. Significance and Impact of the Study: These findings suggest that C. villosus, C. siliqua and H. umbellatum plants may be useful and effective agents for control of citrus sour rot. Such natural products therefore represent a sustainable alternative to the use of synthetic fungicides.

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“…All these events would lead to the inhibition of growth and/or death of the fungus. Feng et al (2011) also reported that PHMGH causes ultrastructural alterations including distortion, deformation and concave collapse in hyphae, plasma membrane disruption in both hyphae and arthroconidia, and cell wall damage in arthroconidia. Arthroconidia, a type of fungal spore typically produced by segmentation of pre-existing fungal hyphae, are metabolically active cells enriched with lipid-containing vacuoles and intracellular organelles.…”

Section: Resultsmentioning

confidence: 93%

Fungicidal activity of AKWATON and in vitro assessment of its toxic effects on animal cells

Oulé

Staines

Lightly

et al. 2015

Journal of Medical Microbiology

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Acquired superficial fungal infections are among the most common infections. It is necessary to create new effective and non-toxic disinfectants. AKWATON is a new disinfectant of the polymeric guanidine family. Its fungicidal activity against Trichophyton mentagrophytes and its in vitro toxicity assessment were determined in this study. The MIC, minimum fungicidal concentration (MFC) and time required for its fungicidal activity at the MFC were evaluated using the official methods of analysis of the Association of Official Analytical Chemists, with modifications as recommended by the Canadian General Standards Board. The toxic effects of AKWATON and of four commercial disinfectants were evaluated on rat pancreatic (C2C12) and muscle (RnM5F) cells, using the trypan blue and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] methods. The MIC, MFC and time required for the fungicidal activity of AKWATON at the MFC were 0.025 % (w/v), 0.045 % (w/v) and 2.5 min, respectively. Cell cultures and the different tests carried out showed that the AKWATON-based disinfectant killed fewer cells than the commercial disinfectants, sparing 80 % of C2C12 cells and 65 % of RnM5F cells, whilst some of the well-known disinfectants currently on the market killed 85-100 % of cells. This study demonstrates that AKWATON has great potential as an odourless, colourless, non-corrosive and safe disinfectant for use in hospitals, the agriculture industry, farming and household facilities.

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Antifungal activities of polyhexamethylene biguanide and polyhexamethylene guanide against the citrus sour rot pathogen Geotrichum citri-aurantii in vitro and in vivo

Cited by 73 publications

References 12 publications

Fabrication of new antifungal polyamide-12 material

Fabrication of new antifungal polyamide-12 material

Antifungal activity of Moroccan medicinal plants against citrus sour rot agent Geotrichum candidum

Fungicidal activity of AKWATON and in vitro assessment of its toxic effects on animal cells

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