Antifungal activities and action mechanisms of compounds from Tribulus terrestris L.

Zhang, Jundong; Xu, Zheng; Cao, Yongbing; Chen, Haisheng; Yan, Lan; An, Mao‐Mao; Gao, Ping-Hui; Wang, Yan; Jia, Xin‐Ming; Jiang, Yuanying

doi:10.1016/j.jep.2005.07.006

Cited by 105 publications

(56 citation statements)

References 30 publications

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“…Shukla et al [16] have shown that ether and ethyl acetate seed extracts of C. bonducella had antifungal activity against A. niger which might be due to the presence of steroids and saponin. Also the use of saponins from Tribulus terrestris exert antifungal activity by inhibiting fungal hyphae and destroying the ultra structure of fungi in particular [17], our results are in strong agreement with their findings.…”

Section: Discussionsupporting

confidence: 92%

Antimicrobial, Cytotoxic and Phytotoxic Potency of Ethyl Acetate Extract of <i>Rhizopus stolonifer</i> Culture

Iqbal¹,

Amin²,

Iqbal³

et al. 2014

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 92%

Antimicrobial, Cytotoxic and Phytotoxic Potency of Ethyl Acetate Extract of <i>Rhizopus stolonifer</i> Culture

Iqbal¹,

Amin²,

Iqbal³

et al. 2014

Trop. J. Pharm Res

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“…The present study shows that ethanol extract from T. terrestris fruits had potent anti-C. albicans activity with an MIC value of 0.62 mg/ml. The antifungal activity of T. terrestris may be attributed to various chemicals detectable in its extracts such as saponins (Zhang et al, 2006). The action mechanisms of saponins may lie in damage to the membrane and leakage of cellular materials, ultimately leading to cell death (Mshvildadze et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq

Al-Bayati

Al-Mola

2008

J. Zhejiang Univ. Sci. B

139

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“…This work had interesting results against Candida species. Candida albicans is the yeast species more often isolated from biological samples being an usual skin and mucosa colonizing agent with many hosts in the oral cavity, and higher incidence rates among young children and patients infected with HIV, but is necessary to pay attention to the emergence of other Candida species as infecting agents (McCullough et al, 1996;Runyoro et al, 2006;Zhang et al, 2006). Resistance to commonly used agents, toxicity and costs impelled the search for new agents and it can be noted that in recent years the research for new active compounds from natural sources has been increasing (Duarte et al, 2005;Runyoro et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Histochemical, phytochemical and biological screening of Plinia cauliflora (DC.) Kausel, Myrtaceae, leaves

Souza-Moreira¹,

Moreira²,

Sacramento³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Rastreamento histoquímico, fitoquímico e biológico de folhas de Plinia cauliflora (DC.) Kausel (Myrtaceae)". No presente trabalho, foram investigadas a composição química e atividades biológicas de extratos brutos obtidos com etanol 50%, etanol 70%, acetona:água (7:3; v/v) e clorofórmio das folhas de Plinia cauliflora (DC.) Kausel, Myrtaceae, uma árvore nativa de várias regiões do Brasil. Os rastreamentos histoquímico e fitoquímico foram feitos de acordo com reações de caracterização e cromatografia em camada delgada. Para auxiliar na padronização dos extratos foram realizadas determinações do teor de fenóis totais e de flavonoides totais, espectrofotometricamente. A atividade antioxidante foi analisada pela porcentagem de sequestro de radicais livres usando solução de DPPH. A atividade antimicrobiana foi avaliada frente a bactérias patogênicas Gram-positivas, Gram-negativas e espécies de Candida utilizando os métodos de difusão em ágar e determinação da concentração inibitória mínima (MIC) de acordo com métodos padronizados. As folhas apresentaram lipídeos nas cavidades secretoras e fenóis, principalmente taninos, nas nervuras e parênquima paliçádico. Os extratos polares apresentaram flavonoides, taninos, alto teor de fenóis totais e de flavonoides totais. Os extratos mostraram elevada atividade antioxidante e a atividade antimicrobiana foi melhor contra as espécies de Candida do que contra as bactérias.Unitermos: Plinia cauliflora, Myrtaceae, rastreamento químico, atividade antioxidante, atividade antimicrobiana. ABSTRACT:In this work, chemical and biological activities of crude extracts obtained with 50% ethanol, 70% ethanol, acetone:water (7:3; v/v) and chloroform of Plinia cauliflora (DC.) Kausel, Myrtaceae, leaves, a native tree from several regions of Brazil, was investigated. Histochemical and phytochemical screenings were done according to characterization reactions and thin layer chromatography. To assist in extracts standardization, total phenol and flavonoids content spectrophotometric was performed. Antioxidant activity was analyzed by percentage of radical scavenging using DPPH solution. Antimicrobial activity was evaluated against Gram-positive, Gram-negative pathogenic bacteria and species of Candida using agar diffusion and minimal inhibitory concentration (MIC) determination methods according to standard methods. The leaves presented lipids at secretory cavity and phenols, mainly tannins, in nervures and palisade parenchyma. Polar extracts showed flavonoids, tannins and high content of phenols and flavonoids. The extracts showed great antioxidant activity and antimicrobial activity was better against Candida species than against bacteria.

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Antifungal activities and action mechanisms of compounds from Tribulus terrestris L.

Cited by 105 publications

References 30 publications

Antimicrobial, Cytotoxic and Phytotoxic Potency of Ethyl Acetate Extract of <i>Rhizopus stolonifer</i> Culture

Antimicrobial, Cytotoxic and Phytotoxic Potency of Ethyl Acetate Extract of <i>Rhizopus stolonifer</i> Culture

Antibacterial and antifungal activities of different parts of Tribulus terrestris L. growing in Iraq

Histochemical, phytochemical and biological screening of Plinia cauliflora (DC.) Kausel, Myrtaceae, leaves

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