Antifouling and Antibacterial Polymer-Coated Surfaces Based on the Combined Effect of Zwitterions and the Natural Borneol

Abstract

The development and application of natural antibacterial materials have always been the focus of biomedical research. Borneol as a natural antibacterial compound has received extensive attention. However, the hydrophobicity caused by its unique structure limits its application range to a certain extent. In this study, we combine zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) with a complex bicyclic monoterpene structure borneol compound and prepare an excellent antifouling and antibacterial surface via the Schiff-base bond. The prepared coating has excellent hydrophilicity verified by the contact angle (CA), and its polymer layer is confirmed by X-ray photoelectron spectroscopy (XPS). The zwitterion MPC and borneol moieties in the copolymer play a coordinating role, relying on super hydration and the special stereochemical structure to prevent protein adsorption and inhibit bacterial adhesion, respectively, which are demonstrated by bovine serum albumin (BSA) adsorption and antibacterial activity test. Moreover, the water-soluble borneol derivative as the antibacterial surfaces we designed here was biocompatible toward MRC-5 (lung fibroblasts), as showed by in vitro cytotoxicity assays. Such results indicate the potential application of the as-prepared hydrophilic surfaces in the biomedical materials.

Biocompatible orthodontic cement with antibacterial capability and protein repellency

“…In this study, the combined use of NAC and NAg resulted in a clinically acceptable biocompatibility according to the ISO [ 30 ], which was not compromised by the incorporation of MPC. This finding is consistent with current evidences suggesting the favorable biocompatibility of MPC [ 31 ], and demonstrates that the combined use of NAC, NAg and MPC can be a safe approach to combat WSLs in clinical practice.…”

Construction of antibacterial adhesion surfaces based on bioinspired borneol-containing glycopolymers

“…The antibacterial activity of the coatings against Escherichia coli (E. coli) (ATCC 25922, USA) and Staphylococcus aureus (S. aureus) (ATCC 25923, USA) was evaluated according to our previous work. 34 The samples were sterilized by UV light and incubated with a bacterial suspension at 37 °C. Then, the plate colony counting and Live/Dead staining assay were carried out to investigate the antibacterial adhesion activity.…”

Biocompatible Materials in Otorhinolaryngology and Their Antibacterial Properties

“…Covalent grafting is more stable than other methods, such as non-covalent bonding (electrostatic attraction and hydrogen bonding). There are some very detailed publications describing two categories of covalent grafting—‘grafting to’ and ‘grafting from’ [ 136 , 137 , 138 , 139 ]. Moreover, the technology of photo-initiation of some monomers or polymers by UV also exists.…”