Antifibrosis effects of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in a rat model of bleomycin-induced pulmonary fibrosis

Abstract

TAL had a positive prophylactic effect on lung fibrosis, which might have been related to its reduction on TNF-α or TGF-β1 expression in the alveolar macrophage of pulmonary fibrosis rats.

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

“…Loquat extracts have shown other bioactivities such as improvement of liver function [66,67], lung [68], renal [65] and neuronal cells [46], and also loquat extracts showed anti-obesity and hypolipidemic activity [36,37,69], anti-thrombotic potential [20], antiaging effects [70], anti-allergic [22], and antinociceptive activities [24], etc.…”

“…By using a rat model of bleomycin-induced pulmonary fibrosis, triterpene acids of loquat leaf showed antifibrosis effects by ameliorating the lung structure and alleviating fibrosis in the rat, where reduced expression of TNF- α and TGF-β1 both at the protein and mRNA levels were observed in the alveolar macrophage of pulmonary fibrosis rats [68]. The triterpene acids present in such loquat extracts included oleanolic acid ( 8 ), α-hydroxyoleanolic acid ( 34 ), arjunic acid ( 35 ), euscaphic acid ( 6 ), and ursolic acid ( 1 ), etc.…”

“…The triterpene acids present in such loquat extracts included oleanolic acid ( 8 ), α-hydroxyoleanolic acid ( 34 ), arjunic acid ( 35 ), euscaphic acid ( 6 ), and ursolic acid ( 1 ), etc. (Figure 5) [68]. …”

Prostaglandin E2Up-regulation and Wound Healing Effect of the Ethanol Extract of Eriobotryae Folium in Human Keratinocyte

“…Moreover extract and isolated compound from leaves of this plant have been reported to be physiological active, exhibiting antioxidant, anti-inflammatory, antitumor, hypoglycemic effect, liver protective effect and antimutagenic (Banno et al, 2005;Bae et al, 2010;Cha et al, 2011aCha et al, , 2011bChoi et al, 2011). Moreover, antifibrosis effects of triterpene acids of Eriobotryae folium has been reported (Yang et al, 2012).…”

Response Surface Optimized Extraction of Total Triterpene Acids from <i>Eriobotrya japonica</i> (Thunb) <i>Lindl</i> (Loquat) Leaf and Evaluation of their In vitro Antioxidant Activities

“…Total triterpene acids possess various pharmacological activities, including antiinflammatory [1], anti-atherosclerotic and antidiabetic activity [2], anti-proliferative [3], and antifibrotic [4]. At the same time, research has shown that triterpene acids possess antioxidant activity [5].…”