Antifibromyalgic activity of standardized extracts of Phyllanthus amarus and Phyllanthus fraternus in acidic saline induced chronic muscle pain

Chopade, Atul R.; Sayyad, Fahim J.

doi:10.1016/j.biomag.2014.01.005

Cited by 17 publications

(10 citation statements)

References 29 publications

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“…The chronic thermal and mechanical hyperalgesia produced in the present model are maintained by spinal or supraspinal neuronal mechanisms, as a result from series of central and peripheral changes occurring at the site of insult (Radhakrishnan et al, ; Chopade and Sayyad, , ; Araldi et al, ; Ossipov et al, ). It is clear from the results of our study that P. amarus extracts can reverse the already established chronic hyperalgesia.…”

Section: Discussionmentioning

confidence: 83%

“…Spinal COX‐2 plays an important role in the maintenance of hyperalgesia induced by carrageenan (Dirig et al, ). After inflammation, allodynia and hyperalgesia occur, generally because of an increase in PGE2 level in the inflamed tissue and in the spinal cord that can be associated with induction and activation of COX‐2 (Chopade and Sayyad, , ). The COX‐2 enzyme is the major source of PGE2 in many inflammatory pain models, and almost all of the COX‐2‐selective inhibitors have shown potent antihyperalgesic activity (Chopade and Sayyad, , ).…”

Section: Discussionmentioning

confidence: 99%

“…A number of preclinical and clinical studies have confirmed the medicinal properties of various Phyllanthus species that have been mentioned in traditional system of medicine (Calixto et al, ; Bagalkotkar et al, ; Joseph and Raj, ; Patel et al, ; Sarin et al, ). Previous studies have reported the analgesic, antiinflammatory, and anti‐arthritic activity of the standardized extracts of P. amarus (Mali et al, ; Kandhare et al, ; Chopade and Sayyad, , ). However, the effects of P. amarus plant on chronic inflammatory muscle hyperalgesia are unexplored, which has encouraged us to evaluate the effects of standardized extracts of P. amarus for their chronic pain modulating potential.…”

Section: Introductionmentioning

confidence: 99%

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Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

Chopade¹,

Sayyad²

2015

Phytotherapy Research

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The current study was aimed at evaluating the antihyperalgesic effects of lignans (phyllanthin and hypophyllanthin) and tannin (corilagin) rich three standardized extracts of Phyllanthus amarus in a model of chronic musculoskeletal inflammatory pain. Three percent carrageenan injected in the gastrocnemius muscle produced hyperalgesia to mechanical and heat stimuli ipsilaterally, which spreads to the contralateral side within 7 to 9 days. To investigate the effects on chronic thermal and mechanical hypersensitivity, three extracts of P. amarus in three doses (100, 200, and 400 mg/kg) were administered to animals intraperitoneally from 14th day to 22nd day after intramuscular injection of carrageenan. It was observed that intraperitoneal administrations of Phyllanthus extracts showed antihyperalgesic activity, as they elevated thermal and mechanical threshold, which was supported by histopathological observations along with reduction in prostaglandin E2 (PGE2) concentration. In conclusion, we strongly suggest that the observed antihyperalgesic and antiinflammatory effects of P. amarus in current pain model are mediated via spinal or supraspinal neuronal mechanisms, mainly by inhibition of PGE2. Modulation of chronic muscular inflammation may be due to presence of phytoconstituents like phyllanthin, hypophyllanthin, and corilagin, which offers a promising means for treatment of chronic muscle pain.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

Chopade¹,

Sayyad²

2015

Phytotherapy Research

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“…Chopade and Sayyad [27] used aqueous, methanolic, hydromethanolic, and hydroethanolic extracts of the genus Phyllanthus in an animal model of FM induced by acid saline. It was observed that the extract was able to reduce hyperalgesia without causing tolerance.…”

Section: Preclinical Studiesmentioning

confidence: 99%

“…In relation to FM, some classes of bioactive compounds extracted from medicinal plants have presented analgesic activity described in the literature, such as essential oils [24][25][26], extracts [27,28], monoterpenes [29][30][31], sesquiterpenes [32], saponins [33], and alkaloids ( Figure 1 and Table 2) [34]. * All preclinical studies used the chronic muscle pain model induced by acid saline.…”

Section: Introductionmentioning

confidence: 99%

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Brito¹,

Santos²,

AlmeidaOliveira³

et al. 2018

Discussions of Unusual Topics in Fibromyalgia

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Fibromyalgia (FM) is the second most common rheumatologic disorder, affecting 5% of the world population, and has a serious effect on the quality of life of patients, as well as an economic impact through lost workdays. This pain syndrome is a common cause of chronic widespread pain and is characterized by reduced pressure pain thresholds with hyperalgesia and allodynia, nonrestorative sleep, fatigue, cognitive dysfunction, and mood disturbances. The pharmacological treatment strategies for FM include the use of antidepressants, calcium channel modulators, muscle relaxants, and analgesics but have shown limited efficacy and therapeutic adherence. Thus, researchers have been seeking potential substances (new chemical entities or through drug repositioning) that could be used for FM treatment. In this context, natural products (NPs) have been shown to be promising pharmacological tools due to the variety of their pharmacological activity and the number of molecular sites available as possible active targets. Recent clinical and preclinical studies have been conducted to verify the possible applicability of NPs such as essential oils (EOs), plants extracts, terpenes, sapogenins, and alkaloids in the treatment of FM. The results have shown that natural products have an analgesic effect in different animal models of FM, probably by activation of inhibitory descending pathways, such as the periaqueductal gray and rostroventromedial medulla. Natural products and their secondary metabolites could therefore be a promising source for FM management. However, translational studies that seek to validate the preclinical studies are scarce, incipient, and lacking an approach focused on the traditional pharmaceutical market.

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Herbal Medicine and Rheumatic Disorders Management and Prevention

Widyowati,

Pratama,

Sholikhah

et al. 2023

Reference Series in Phytochemistry

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Antifibromyalgic activity of standardized extracts of Phyllanthus amarus and Phyllanthus fraternus in acidic saline induced chronic muscle pain

Cited by 17 publications

References 29 publications

Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Herbal Medicine and Rheumatic Disorders Management and Prevention

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