Antifibrin action of phenformin

In five volunteers fibrinolytic activity has been measured five times over a period of six weeks during increasing values of circadian rhythm. Euglobulinlysis-time, paper fibrinolysis, fibrinogen, plasminogen, alpha1-antitrypsin, alpha2-makroglobulin, thrombino-coagulase-time and fibrin-split-products were used in one study. An increase of fibrinolytic activity in the mooning was observed in all volunteers. Intraindividual variation of values is considerable but less than variation of values compared interindividually. Moreover variation was smaller at noon than in the time before noon. In clinical trial of the short-time effect of drugs the period of the plateau of the fibrinolytic activity should be used because of its smaller variation of values. Furthermore, in this period the intraindividual variation of the fibrinolytic activity is smaller than during increasing slope of the circadian rhythm of fibrinolysis. Intraindividual control should be granted.

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Hypoglycemic treatments and the fibrinolytic system in maturity-onset diabetes mellitus without thromboembolic manifestations

Gamba

Grignani

Biancardi

et al. 1984

Acta diabet. lat

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The effect of a purified PHA-B fraction of Agaricus bisporus lectin on insulin release and 45Ca2+ uptake by islets of Langerhans was studied. It was found that at 2 mM glucose +17.5 micrograms/ml A. bisporus PHA-B (which produces half-maximal stimulation) there was a 3.3 fold increase in insulin secretion as compared to controls (2 mM glucose). Stimulation of insulin release was found to be dose-related as well as time-dependent. Maximal stimulation of insulin release was obtained at a lectin concentration of about 60 micrograms/ml and proceeded as a linear function of time for about 1 h. It was found that in the presence of 2 mM glucose +17.5 micrograms/ml lectin islet 45Ca2+ uptake was enhanced more than 11-fold as compared to controls. 45Ca2+ uptake was found to be lectin dose- and time-dependent and maximal uptake was achieved at a lectin concentration of about 60 micrograms/ml after which the rate slowed down until it reached a stationary phase at about 75 micrograms/ml.

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Antifibrin action of phenformin

Cited by 10 publications

References 24 publications

Die klinische Anwendung der Biguanide

Die klinische Anwendung der Biguanide

Die intraindividuelle Streuung der fibrinolytischen Aktivit�t bei Probanden

Hypoglycemic treatments and the fibrinolytic system in maturity-onset diabetes mellitus without thromboembolic manifestations

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