Antifertility effects of PGE2 and PGF2α

Aref, I; Gottschewski, Georg; Hafez, E. S. E.

doi:10.1016/0010-7824(74)90007-9

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…There is increasing evidence that prostaglandins (PGs) play a central role in the regulation of oviductal contractility in a variety of species (1) and studies in the rabbit have indicated that both the tissue levels of endogenous PGs (2) and…”

Section: Introductionmentioning

confidence: 99%

Prostaglandins and the Contractile Function of the Human Oviductal Ampulla

Caschetto¹,

Lindblom²,

Wiqvist³

et al. 1979

Gynecol Obstet Invest

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Millimeter-wide muscle strips were prepared from the circular and longitudinal musculature of the oviductal ampulla of fertile women. These specimens were mounted in organ baths for isometric recording of contractile activity. The two types of strips exhibited similar rhythmic spontaneous activity which was found to be present in all phases of the menstrual cycle. Prostaglandin E₂ (PGE₂) caused an inhibition of contractile activity in both the circular and longitudinal layers, whereas PGF₂_Α induced a marked excitatory response in the specimens. Administration of prostacyclin (PGI₂) also elicited an excitatory effect although much less pronounced than that of PGF_2Α. Pretreatment with ETA, a blocker of endogenous prostaglandin synthesis, abolished the spontaneous contractile activity in a concentration-dependent manner. It is concluded that the ampullary portion of the human oviduct possesses pharmacological properties which differ in certain important respects from those of the isthmus. A shift in the tissue levels of endogenous prostaglandin levels may occur in sequence with ovulation and the pattern of the prostaglandins synthesized seems to be appropriate for the contractile function of the various tubal segments during ovum transport in women.

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Section: Introductionmentioning

confidence: 99%

Prostaglandins and the Contractile Function of the Human Oviductal Ampulla

Caschetto¹,

Lindblom²,

Wiqvist³

et al. 1979

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Reproductive processes may be in part mediated by prostanoid actions, and alterations of their ambient levels have been shown to affect ovulation in lower mammals 29 ; to be luteolytic in primates [30][31][32] , and to affect tubal motility, hence ovum/embryo transport, and potentially early implantation in laboratory animals. 33,34 Patients with endometriosis and dysmenorrhea produce more PGs as measured in their menstruum 35 and this can account for their symptomatology. In addition, ectopic endometrium (endometriotic implants) produce these same metabolites 36,37 when studied in vitro.…”

Section: Hormonal Environmentmentioning

confidence: 99%