Prostaglandins and the Contractile Function of the Human Oviductal Ampulla

Caschetto, S; Lindblom, Bo; Wiqvist, N.; Wilhelmsson, L.

doi:10.1159/000299965

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…T h e isthmic inner longitudinal muscle layer showed significantly higher spontaneous frequency of contractions compared to the isthmic circular muscle layer from the same oviducts (P < 0.01, n = 32). In the ampulla, no significant difference in frequency between the muscle layers was found in paired analysis, confirming the findings by Caschetto et al 1979. In all layers except the isthmic external longitudinal and the ampullary longitudinal layer, a significantly higher frequency was found during the proliferative phase compared to the secretory phase ( Fig.…”

Section: A T E R I a L S A N D Methodssupporting

confidence: 86%

Myogenic and neurogenic control of electrical and mechanical activity in human oviductal smooth muscle

Samuelson

Sjöstrand

1986

Acta Physiologica Scandinavica

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Isolated strips from isthmic and ampullary muscle layers of the human fallopian tube were investigated with the sucrose-gap technique and in organ baths. Generally good correlation existed between electrical and mechanical activity, but dissociation was also noted. The isthmic external longitudinal layer (IEL) was characterized by slow waves of depolarization and broad 'spikes'. Tonic contraction followed depolarization, and phasic waves followed the spikes. In the other layers, regular spikes and phasic contractions dominated. Late in the menstrual cycle, more irregular patterns and slow waves, which could synchronize spike activity, were found. Automaticity tended to be highest in the late proliferative phase. Active response to stretch was best demonstrated in IEL. Excitatory alpha-adrenergic responses (hypopolarization, firing and contraction) to noradrenaline and nerve stimulation dominated in the IEL. In the other layers, beta-adrenergic inhibition prevailed. Non-adrenergic, non-cholinergic neurogenic inhibition was demonstrated. Decrease in spike frequency and hyperpolarization seemed to be as prominent as during beta-adrenergic inhibition. Muscarinic stimulation by acetylcholine was recorded as depolarization, spikes and contraction. However, a role for cholinergic nerves could not be defined. Thus, the human oviductal smooth muscle belongs to the single unit category; its activity can be modified during the menstrual cycle, by stretch and by excitatory and inhibitory nerves.

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Section: A T E R I a L S A N D Methodssupporting

confidence: 86%

Myogenic and neurogenic control of electrical and mechanical activity in human oviductal smooth muscle

Samuelson

Sjöstrand

1986

Acta Physiologica Scandinavica

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“…Furthermore, we have shown that these changes are necessary to facilitate the storage of sperm. Non-protein components of the male ejaculate had previously been shown known to affect the muscle contraction state of the mammalian female RT (26,27,35,36). Our results identify a seminal fluid protein that regulates postmating uterine conformation, in Drosophila.…”

Section: Resultsmentioning

confidence: 50%

Acp36DE is required for uterine conformational changes in mated Drosophila females

Avila

Wolfner

2009

Proc. Natl. Acad. Sci. U.S.A.

113

134

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In a multitude of animals with internal fertilization, including insects and mammals, sperm are stored within a female's reproductive tract after mating. Defects in the process of sperm storage drastically reduce reproductive success. In Drosophila males, ''Acp'' seminal proteins alter female postmating physiology and behavior, and are necessary for several aspects of sperm storage. For example, Acps cause a series of conformational changes in the mated female's reproductive tract that occur during and immediately after mating. These conformational changes have been hypothesized to aid both in the movement of sperm within the female and in the subsequent storage of those sperm. We used RNAi to systematically knock down several Acps involved in sperm storage to determine whether they played a role in the mating-induced uterine conformational changes. Mates of males lacking the glycoprotein Acp36DE, which is needed for the accumulation of sperm in the storage organs, fail to complete the full sequence of the conformational changes. Our results show that uterine conformational changes are important for proper accumulation of sperm in storage and identify a seminal protein that mediates these changes. Four Acps included in this study, previously shown to affect sperm release from storage (CG9997, CG1656, CG1652, and CG17575), are not necessary for uterine conformational changes to occur. Rather, consistent with their role in later steps of sperm storage, we show here that their presence can affect the outcome of sperm competition situations.reproduction ͉ seminal protein ͉ sperm competition ͉ sperm storage

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“…In rabbits, the elevated estrogens at ovulation stimulate the a receptors, increasing tubal contractility, and are involved in retaining the ovum in the ampulla near the AIJ. After ovulation, the elevation in progesterone stimulates the B receptors, causing relaxation of the AIJ, allowing transport of the ovum into the isthmic portion of the tube (23,24).…”

Section: Discussionmentioning

confidence: 99%