Antifertility Activity of Hydroalcoholic Extract of Ocimum Basilicum Linn. Leaves on Female Wistar Rats

Bilal, Alia; Jahan, Nasreen; Ahmed, Ajij; Bilal, Saima Naaz; Habib, Shahida

doi:10.1016/s1001-7844(13)60020-6

Cited by 18 publications

(18 citation statements)

References 12 publications

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“…This observation can be attributed to the fact that the solvent used (70% hexane: 30% ethyl acetate) for fraction ii helps to release more alkaloids, glycosides, flavonoids, and several other classes of compounds with antioxidant mechanisms related biological properties (Zhang et al 2009;Sobhy et al 2021). Hence, the observed antioxidant activity in the result agreed with the work of Jayasinghe et al (2003) and Bilal et al (2013) who showed that Ocimum basilicum possesses antioxidant properties that aid it's the ability to relieve oxidative stress in rats.…”

Section: Discussionsupporting

confidence: 89%

The Antioxidant and Hematopoietic Effects of the Methanolic Extract Fractions of Ocimum basilicum in Acetaminophen-Induced Albino Rats

2022

Int J Vet Sci

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This study investigated the antioxidant properties of the fractions of the methanolic extract of Ocimum basilicum (OB) and their effects on the hematological parameters of acetaminophen-induced albino rats. Using vacuum liquid chromatography, the methanolic extract of OB was separated into four fractions (i, ii, iii, and iv) and studied using the DPPH and FRAP assays. Selected fractions ii and iv with the highest antioxidant activities for the animal study. Forty-two albino rats were divided into seven treatment groups (GP) of six animals each, subdivided into three replicates with two rats each. For seven days, rats in GP1 and GP2 were administered water and silymarin (1000mg/kg), gave those in GP4 and GP5 500mg/kg and 1000mg/kg of fraction ii, respectively, while gave those in GP6 and GP7 500mg/kg and 1000mg/kg of fraction iv respectively. Rats in GP3 were administered 750mg/kg of acetaminophen (per os) on day eight only. The results showed that, in comparison with the control groups (1, 2, and 3), rats in GRP4 showed increased (P<0.05) hemoglobin concentration and total WBC count while GRP5 had increased (P<0.05) PCV and MCV. Rats in GRP 6 showed increased (P<0.05) MCV and MCHC compared to the control group, while those in GRP7 showed decreased (P<0.05) PCV and MCV compared with the positive control. It was concluded that the free radical scavenging activity of methanolic extract fractions of OB increased in a dose-dependent manner and high doses (1000mg/kg) of fraction ii showed increased hematopoietic activity.

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Section: Discussionsupporting

confidence: 89%

The Antioxidant and Hematopoietic Effects of the Methanolic Extract Fractions of Ocimum basilicum in Acetaminophen-Induced Albino Rats

2022

Int J Vet Sci

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“…The method of Sasikala and Shamila 18 and Jadhav et al 19 was followed with slight modification in the treatment schedule. First the animals were weighed, checked for two consecutive normal estrus cycles by vaginal smear examination, microscopically, 20 and divided in to four groups of six animals each. Group I served as negative control and received 1 mL of 0.5% CMC.…”

Section: Methodsmentioning

confidence: 99%

“…Three types of cells were recognized: round and nucleated cells were epithelial cells; irregular cells without a nucleus were the cornified cells; and the small round cells were the leucocytes, their mutual proportion was used for the determination of different phases of the estrus cycle. 20 …”

Section: Methodsmentioning

confidence: 99%

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Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats

Saiyed

Jahan

Makbul

et al. 2016

Integrative Medicine Research

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“…2 Advances in Polymer Technology also used in a folk medicinal value [14][15][16][17][18][19]. O. basilicum L. (OB; sweet basil) seeds (OBS) have the ability to swell 10-12 times of their original volume [20].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Lodhi

Hussain

Sher

et al. 2019

Advances in Polymer Technology

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This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L. for its evaluation as a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system. O. basilicum (Syn: Basil) seed hydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water. Highly reversible on-off switching (swellingdeswelling) behavior of BSH was ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline. Scanning electron microscopy (SEM) of BSH has revealed macroporous structure of BSH having average pore size of 1.92 ± 3.83 m noted after swelling and lyophilization. BSH containing tablet formulations showed a sustained release pattern of diclofenac sodium (DS) which is dependent on the concentration of BSH. When comparing with commercially available formulation of DS, even better sustained release behavior of DS was observed in BSH-based formulation. Super case-II transport mechanism is followed by the DS release from BSH matrix tablet. Haemocompatibility studies of BSH were also performed and found it nonhaemolytic and nonthrombogenic. Recently, polysaccharide-based hydrogels have gained a lot of interest in drug delivery system due to their extraordinary swelling indices, stimuli responsive properties, biodegradability, biocompatibility, and nontoxicity [9][10][11][12][13].Ocimum basilicum L., (Syn: sweet basil in English, Babui tulsi in Hindi and Marathi, Rihan in Arabic, Niasabo in Gujrati, Jangli tulsi in Urdu, Tohrakhurasani in Persian, and Okimon in Unani) is a popular culinary and ornamental herb

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Antifertility Activity of Hydroalcoholic Extract of Ocimum Basilicum Linn. Leaves on Female Wistar Rats

Cited by 18 publications

References 12 publications

The Antioxidant and Hematopoietic Effects of the Methanolic Extract Fractions of Ocimum basilicum in Acetaminophen-Induced Albino Rats

The Antioxidant and Hematopoietic Effects of the Methanolic Extract Fractions of Ocimum basilicum in Acetaminophen-Induced Albino Rats

Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats

Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

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