Antiepileptic potential of &lt;i&gt;Silybum marianum&lt;/i&gt; seeds in pentylenetetrazol-induced kindled mice

Waqar, Huma; Khan, Humaira Majeed; Anjum, Aftab Ahmad

doi:10.3329/bjp.v11i3.26181

Cited by 8 publications

(6 citation statements)

References 11 publications

(15 reference statements)

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“…Hence, it will be essential to pay attention to traditional medicine and herbal medicines to achieve low-risk drugs with minimal side effects (Rostampour et al, 2014). The plants such as Aitchisonia rosea (Rasool et al, 2015), Bacopa monnieri (Paulose et al, 2008), Cannabis sativa (Leite and Carlini, 1973), Cyperus articulates (Bakanova and Leutskií, 2971), Sechium edule (Mumtaz et al, 2012), Silybum marianum (Waqar et al, 2016) and Zizyphus jujube (Puhaja et al, 2011) showed antiepileptic effect. (Wan et al, 2017), and sedative (Amos et al, 2003) effects in animal models.…”

Section: Introductionmentioning

confidence: 99%

Effect of Artemisia persica on seizure severity and memory and learning disorders in pentylenetetrazole-kindled mice

Daneshkhah

Setorki

2019

Bangladesh J Pharmacol

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The purpose of this study was to investigate the effect of hydroalcoholic extract of Artemisia persica (100, 200 and 400 mg/kg) on pentylenetetrazole-induced seizure and memory impairment. Sixty mice were assigned to seven groups. Pentylenetetrazole (35 mg/kg) was injected at 48 hours intervals for 9 days, and at 60 mg/kg on day 10 to induce seizure model. Different doses of A. persica extract were injected daily 30 min before pentylenetetrazole injection. Exposure of mice to extract significantly reduced the frequency of repeated spinning and jumping and tonic seizures in seizure model. In addition, the extract significantly reduced the increased levels of malondialdehyde in serum and brain. The extract significantly increased the serum and brain anti-oxidant capacity but had no significant effect on nitric oxide. The extract (100 mg/kg) significantly improved pentylenetetrazole-induced memory impairment. The hydro-alcoholic extract of A. persica has a protective effect against pentylenetrazole-induced seizure. Video Clip of Methodology: 1 min 56 sec: Full Screen Alternate

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Section: Introductionmentioning

confidence: 99%

Effect of Artemisia persica on seizure severity and memory and learning disorders in pentylenetetrazole-kindled mice

Daneshkhah

Setorki

2019

Bangladesh J Pharmacol

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“…Similarly, 300 mg/kg Silybum marianum seed extract was used, which demonstrate the obvious stability against PTZ-induced convulsions (fatality, duration, and seizure frequency). Moreover, a 300 mg/kg dose of the extract was observed to be efficient in preventing oxidative stress in the brain of mice, leading to significantly higher antiepileptic activity …”

Section: Resultsmentioning

confidence: 99%

“…Moreover, a 300 mg/kg dose of the extract was observed to be efficient in preventing oxidative stress in the brain of mice, leading to significantly higher antiepileptic activity. 34 …”

Section: Resultsmentioning

confidence: 99%

“…Moreover, a 300 mg/kg dose of the extract was observed to be efficient in preventing oxidative stress in the brain of mice, leading to significantly higher antiepileptic activity. 34 Effect of TiO 2 NPs on MESE-Induced Epilepsy. The treatment-resistant epileptic patients were tested using the maximal electroshock seizure (MESE) model to demonstrate the effectiveness of antiepileptic medications against generalized and partial seizure epilepsy.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Biofabrication of Titanium Dioxide Nanoparticles Catalyzed by Solanum surattense: Characterization and Evaluation of their Antiepileptic and Cytotoxic Activities

et al. 2023

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The green synthesis of nanoparticles using plant extract is a new method that can be used in various biomedical applications. Therefore, the green approach was an aspect of ongoing research for the synthesis titanium dioxide nanoparticles (TiO2 NP) using the Solanum surattense aqueous plant extract, which acts as a stabilizing and reducing agent. The synthesis of TiO2 NPs was confirmed by energy dispersive X-ray (EDX), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and UV–visible spectroscopy (UV–vis) analyses. The excitation energy to synthesize TiO2 NPs was identified through the UV–vis spectrophotometric analysis at a wavelength of 244 nm. Further, the FT-IR spectroscopy visualized different biomolecules like OH, CO, C–H, and C–O that were present in an aqueous extract of the plant and were responsible for the stabilization of TiO2 NPs. The crystallinity and phase purity of TiO2 NPs were illustrated by the sharp peaks of the XRD pattern. The spherical morphology with sizes ranging from 10 to 80 nm was examined using SEM images. The elemental composition of TiO2 NPs was revealed by the intensity and narrow widths of titanium and oxygen using EDX analysis. This report also explains the antiepileptic activity of TiO2 NPs in a maximal electroshock-induced epileptic (MESE) and pentylenetetrazol (PTZ) model. The synthesized TiO2 NPs showed maximum antiepileptic activity in the PTZ model, significantly decreasing the convulsions (65.0 ± 5.50 s) at 180 mg/kg in contrast to standard drug phenytoin, whereas the MESE model was characterized by the appearance of extensor, clonus, and flexion. The results showed that synthesized TiO2 NPs significantly reduced the time spent in each stage (15.3 ± 0.20, 16.8 ± 0.25, and 20.5 ± 0.14 s) at 180 mg/kg as compared to control groups. Furthermore, the cytotoxicity of synthesized produced TiO2 NPs demonstrated that concentrations ≤80 μg/mL were biologically compatible.

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“…Silybum marianum is another anticonvulsive herbal with antioxidant and antiseizure effects, lowering the frequency and duration of convulsions in PTZ experimental mice and reducing PTZ-induced lethality [ 64 ] (Fig. 2 ).…”

Section: Methodsmentioning

confidence: 99%

Analysis of the action mechanisms and targets of herbal anticonvulsants highlights opportunities for therapeutic engagement with refractory epilepsy

Tabassum,

Shorter,

Ovsepian

2024

J Mol Med

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Epilepsy is a neurological disorder characterized by spontaneous and recurring seizures. It poses significant therapeutic challenges due to diverse etiology, pathobiology, and pharmacotherapy-resistant variants. The anticonvulsive effects of herbal leads with biocompatibility and toxicity considerations have attracted much interest, inspiring mechanistic analysis with the view of their use for engagement of new targets and combination with antiseizure pharmacotherapies. This article presents a comprehensive overview of the key molecular players and putative action mechanisms of the most common antiepileptic herbals demonstrated in tissue culture and preclinical models. From the review of the literature, it emerges that their effects are mediated via five distinct mechanisms: (1) reduction of membrane excitability through inhibition of cation channels, (2) improvement of mitochondrial functions with antioxidant effects, (3) enhancement in synaptic transmission mediated by GABAA receptors, (4) improvement of immune response with anti-inflammatory action, and (5) suppression of protein synthesis and metabolism. While some of the primary targets and action mechanisms of herbal anticonvulsants (1, 3) are shared with antiseizure pharmacotherapies, herbal leads also engage with distinct mechanisms (2, 4, and 5), suggesting new drug targets and opportunities for their integration with antiseizure medications. Addressing outstanding questions through research and in silico modeling should facilitate the future use of herbals as auxiliary therapy in epilepsy and guide the development of treatment of pharmacoresistant seizures through rigorous trials and regulatory approval.

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Antiepileptic potential of <i>Silybum marianum</i> seeds in pentylenetetrazol-induced kindled mice

Cited by 8 publications

References 11 publications

Effect of Artemisia persica on seizure severity and memory and learning disorders in pentylenetetrazole-kindled mice

Effect of Artemisia persica on seizure severity and memory and learning disorders in pentylenetetrazole-kindled mice

Biofabrication of Titanium Dioxide Nanoparticles Catalyzed by Solanum surattense: Characterization and Evaluation of their Antiepileptic and Cytotoxic Activities

Analysis of the action mechanisms and targets of herbal anticonvulsants highlights opportunities for therapeutic engagement with refractory epilepsy

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