Effect of Artemisia persica on seizure severity and memory and learning disorders in pentylenetetrazole-kindled mice

Abstract

The purpose of this study was to investigate the effect of hydroalcoholic extract of Artemisia persica (100, 200 and 400 mg/kg) on pentylenetetrazole-induced seizure and memory impairment. Sixty mice were assigned to seven groups. Pentylenetetrazole (35 mg/kg) was injected at 48 hours intervals for 9 days, and at 60 mg/kg on day 10 to induce seizure model. Different doses of A. persica extract were injected daily 30 min before pentylenetetrazole injection. Exposure of mice to extract significantly reduced the frequency of repeated spinning and jumping and tonic seizures in seizure model. In addition, the extract significantly reduced the increased levels of malondialdehyde in serum and brain. The extract significantly increased the serum and brain anti-oxidant capacity but had no significant effect on nitric oxide. The extract (100 mg/kg) significantly improved pentylenetetrazole-induced memory impairment. The hydro-alcoholic extract of A. persica has a protective effect against pentylenetrazole-induced seizure.
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Neuroprotective efficacy of Marsilea quadrifolia leaf extract against pentylenetetrazole-induced seizure in rat model of epilepsy.

“…It has been shown that the hippocampus is closely involved in learning and memory, especially spatial cognitive function (Bhagya et al, 2015; Cavazos et al, 1991; Cavazos & Sutula, 1990). The present findings are in agreement with studies that have shown PTZ administration induced an increase in 5-HT and 5-HIAA content in the hippocampus, which caused an imbalance of the serotonergic system resulting in an alteration in cognitive behavior like learning and memory (Daneshkhah & Setorki, 2019; Svob Strac et al, 2016). In the present study, PTZ-treated groups showed a significant increase ( p < .05) in brain 5-HT and 5-HIAA metabolite concentrations with a reduction in 5-HT level in the hippocampus after MQLE co-supplementation following PTZ administration, suggesting a restoration of spatial learning and memory system.…”

NMDA Receptor Mediates the Anticonvulsant Effect of Hydroalcoholic Extract of Artemisia persica in PTZ-Induced Seizure in Mice

“…Group 1 received normal saline at a dose of 1 ml/kg, groups 2–4 received A. persica ethanolic extract at doses of 100, 200, and 400 mg/kg, i.p. [ 28 ], and group 5 received subeffective dose of A. persica ethanolic extract plus subeffective dose of ketamine (NMDA receptor antagonist, 0.5 mg/kg) [ 33 ]. The sixth group received the effective dose of A. persica extract plus the effective dose of NMDA agonist (150 mg/kg) [ 34 ].…”

“…e roots, stems, and leaves of A. persica are used to treat coughs, fevers, loss of appetite, colic, headaches, earaches, and parasitic diseases and malaria [26]. Previous studies have determined that ethanolic extract of A. persica possessed neuroprotective, antidepressant-like, and anxiolytic-like effects, as well as improving cognition and memory in various experimental models in rodents [27][28][29][30]. e antiepileptic effect of extract of A. persica has been reported previously; however, the underlying mechanisms involved in this effect are not determined [28].…”

Ameliorative potential of Anacyclus pyrethrum extract in generalized seizures in rat: Possible cholinergic mediated mechanism

“…To overcome these problems, several studies conducted in recent years have supported the use of herbal remedies as alternatives. To this end, animal studies have shown that several plants such as Abies webbiana (Parkash et al, 2015), Artemisia persica (Daneshkhah and Setorki, 2019), Carum carvi (Showraki et al, 2016), Citrus sinensis (Citraro et al, 2016), Crocus sativus (Khazdair et al, 2015), Dodonaea viscosa (Karim et al, 2015), paralysis, toothache, and epilepsy (Annalakshmi et al, 2012;Boonen et al, 2012). Aqueous extracts are nontoxic and are being used as aphrodisiacs to improve male libido (Sharma et al, 2009;Sujith et al, 2012).…”