Antiemetic prophylaxis with promethazine or droperidol in paediatric outpatient strabismus surgery

Blanc, Victor Faria; Ruest, Pierre; Milot, Jean; Jacob, Jean-Louis; Tang, Alexander

doi:10.1007/bf03009164

Cited by 31 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that it is related to the oculocardiac reflex [13]. But the incidence of nausea is still high, even though this reflex can be inhibited by atropine or glycopyrrolate [2,14]. Another hypothesis is an oculo-emetic reflex arising from stress in the squint-corrected eye [15].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children

Shende

Mandal

1997

Anaesthesia

View full text Add to dashboard Cite

SummaryA double-blind, randomised, placebo-controlled trial was conducted to compare the efficacy of metoclopramide with the 5-HT 3 antagonist, ondansetron, for the prevention of postoperative emesis in children undergoing elective strabismus surgery. None of the children received any premedication and a similar anaesthetic technique was used for all. Ondansetron 0.15 mg.kg ÿ 1 , metoclopramide 0.25 mg.kg ÿ 1 or saline placebo were administered following intravenous catheter placement. Episodes of emesis were recorded for the first 24 h for the intervals of 0-2, 2-6 and 6-24 h. The incidence of emesis in the first 24 h was observed to be 71.7% in the placebo group, 34.4% in the ondansetron group (p < 0.001) and 61.4% in the metoclopramide group (p = NS). The severity of vomiting was less in the ondansetron group as compared with metoclopramide (p < 0.01) and placebo (p < 0.001). Recovery room scores were comparable in all the groups. No serious side-effects were observed in the ondansetron group. We conclude that prophylactic ondansetron is effective and superior to metoclopramide in the prevention of postoperative emesis in children following elective strabismus surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Corrective strabismus surgery in children is associated with a high incidence of postoperative emesis [2]. Prophylactic administration of metoclopramide has been shown to reduce postoperative vomiting significantly in this population [3,4].…”

mentioning

confidence: 99%

Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children

Shende

Mandal

1997

Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Promethazine offers the advantage of low cost, slowintramuslar absorption, and long elimination half-life [65], making it potentially attractive for use in outpatient surgery [66]. However, Parlow et al demonstrated that promethazine 0.6 mg/kg intramuscularly (i.m.)…”

Section: Traditional Antiemetics (Table 1)mentioning

confidence: 98%

The Utility of Antiemetics in the Prevention and Treatment of Postoperative Nausea and Vomiting in Patients Scheduled for Laparoscopic Cholecystectomy

Fujii

2005

CPD

View full text Add to dashboard Cite

Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events of anesthesia and surgery, with a relatively high incidence after laparoscopic cholecystectomy. Numerous antiemetics have been studied for the prevention and treatment of PONV in patients scheduled for laparoscopic cholecystectomy. Traditional antiemetics, including anticholinergics (e.g., scopolamine), antihistamines (e.g., dimenhydrinate), phenothiazines (e.g., promethazine), butyrophenones (e.g., droperidol), and benzamide (e.g., metoclopramide), are used for the control of PONV. The available nontraditional antiemetics for the prophylaxis against PONV are dexamethasone and propofol. Serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron), compared with traditional antiemetics, are highly efficacious for PONV. The prophylactic ondansetron, granisetron, tropisetron, and dolasetron in antiemetic efficacy are comparable. Ramosetron is effective for the long-term prevention of PONV. None of the available antiemetics is entirely effective, perhaps because most of them act through the blockade on one type of receptor. There is a possibility that combined antiemetics with different sites of activity would be more effective than one drug alone for the prophylaxis against PONV. Combination antiemetic therapy is often effective for the prevention of PONV following laparoscopic cholecystectomy. The efficacy of a combination of serotonin receptor antagonists (ondansetron and granisetron) and droperidol is superior to monotherapy with a serotonin receptor antagonist or droperidol. Similarly, adding dexamethasone to ondansetron or granisetron improves antiemetic efficacy in PONV. Knowledge regarding antiemetics is necessary to completely prevent and treatment of PONV in patients scheduled for laparoscopic cholecystectomy.

show abstract

“…Some authors even suggest that propofol has antiemetic properties in the postoperative period [11]. Different antiemetic agents such as droperidol, metaclopropamide and promethazine have been evaluated in the prophylaxis of nausea and vomiting [12, 13, 14]. But these drugs have unwanted side effects such as somnolence, dry mouth and restlessness.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Halothane/Thiopental and Propofol Anesthesia for Strabismus Surgery

Serin

Elibol²,

Sungurtekin³

et al. 1999

Ophthalmologica

View full text Add to dashboard Cite

Day case surgery has become a widely accepted practice for many ophthalmological procedures including strabismus surgery. Prompt recovery from anesthesia and minimal postoperative morbidity are especially requested to the anesthesiologists to deal with the high day case surgery burden. The purpose of this study was to compare two anesthesia techniques, halothane/thiopental anesthesia and propofol anesthesia, for patients undergoing monocular strabismus surgery. We studied the level of postoperative consciousness, nausea and vomiting, ocular pain, starting oral intake and activity in 43 patients, ranging from 7 to 41 years of age. A scoring system was used to assess these parameters in the first postoperative 48 h. Although there was not a significant difference in the level of ocular pain, the propofol group had less morbidity in terms of having a better level of consciousness and appetite, less nausea and vomiting and enhanced activity than the halothane/thiopental group. We conclude that propofol anesthesia has significant advantages over halothane/thiopental anesthesia on an outpatient basis for strabismus surgery.

show abstract

Antiemetic prophylaxis with promethazine or droperidol in paediatric outpatient strabismus surgery

Cited by 31 publications

References 25 publications

Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children

Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children

The Utility of Antiemetics in the Prevention and Treatment of Postoperative Nausea and Vomiting in Patients Scheduled for Laparoscopic Cholecystectomy

Comparison of Halothane/Thiopental and Propofol Anesthesia for Strabismus Surgery

Contact Info

Product

Resources

About