Antiedema effects of proanthocyanidin on experimental traumatic brain edema

Yavuz, Erdem; Tekiner, Ayhan; Erkoç, Yavuz Selim; Yılmaz, Muhittin; Çelik, Haydar; Yıldırım, Ali Erdem; Tekiner, Ayşe Selda; Bayar, Mehmet Akif

doi:10.5137/1019-5149.jtn.10359-14.2

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…ROS levels increased by “oxidation therapy” can trigger cell death via necrosis or apoptosis. 97 Flavonoids, such as quercetin, 98 , 99 catechins, 100 and proanthocyanins, 101 , 102 protect glial cells from inflammation and oxidative stress. These compounds exert protective effects in the brains of patients with cancer and help prevent traumatic brain injury.…”

Section: Clinical Approach and Future Researchmentioning

confidence: 99%

The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research

Lan¹,

Zhu²,

Chen³

et al. 2021

JIR

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The role of traumatic brain injury in the development of glioma is highly controversial since first presented. This is not unexpected because traumatic brain injuries are overwhelmingly more common than glioma. However, the causes of post-traumatic glioma have been long discussed and still warrant further research. In this review, we have presented an overview of previous cohort studies and case–control studies. We have summarized the roles of microglial cells, macrophages, astrocytes, and stem cells in post-traumatic glioma formation and development, and reviewed various carcinogenic factors involved during traumatic brain injury, especially those reported in experimental studies indicating a relationship with glioma progression. Besides, traumatic brain injury and glioma share several common pathways, including inflammation and oxidative stress; however, the exact mechanism underlying this co-occurrence is yet to be discovered. In this review, we have summarized current epidemiological studies, clinical reports, pathophysiological research, as well as investigations evaluating the probable causes of co-occurrence and treatment possibilities. More efforts should be directed toward elucidating the relationship between traumatic brain injury and glioma, which could likely lead to promising pharmacological interventions towards designing therapeutic strategies.

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Section: Clinical Approach and Future Researchmentioning

confidence: 99%

The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research

Lan¹,

Zhu²,

Chen³

et al. 2021

JIR

View full text Add to dashboard Cite

show abstract

Antioxidant Therapies in Traumatic Brain Injury

et al. 2020

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Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly heterogeneous pathology, characterized by high mortality and disability rates. TBI is an acute neurodegenerative event, potentially and unpredictably evolving into sub-chronic and chronic neurodegenerative events, with transient or permanent neurologic, cognitive, and motor deficits, for which no valid standardized therapies are available. A vast body of literature demonstrates that TBI-induced oxidative/nitrosative stress is involved in the development of both acute and chronic neurodegenerative disorders. Cellular defenses against this phenomenon are largely dependent on low molecular weight antioxidants, most of which are consumed with diet or as nutraceutical supplements. A large number of studies have evaluated the efficacy of antioxidant administration to decrease TBI-associated damage in various animal TBI models and in a limited number of clinical trials. Points of weakness of preclinical studies are represented by the large variability in the TBI model adopted, in the antioxidant tested, in the timing, dosages, and routes of administration used, and in the variety of molecular and/or neurocognitive parameters evaluated. The analysis of the very few clinical studies does not allow strong conclusions to be drawn on the real effectiveness of antioxidant administration to TBI patients. Standardizing TBI models and different experimental conditions, as well as testing the efficacy of administration of a cocktail of antioxidants rather than only one, should be mandatory. According to some promising clinical results, it appears that sports-related concussion is probably the best type of TBI to test the benefits of antioxidant administration.

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Antiedema effects of proanthocyanidin on experimental traumatic brain edema

Cited by 2 publications

References 21 publications

The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research

The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research

Antioxidant Therapies in Traumatic Brain Injury

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