Antidyslipidemic Potential of Water-Soluble Polysaccharides of Ganoderma applanatum in MACAPOS-2-Induced Obese Rats

Mfopa, Adamou; Kengne, Francine Mediesse; Mvongo, Clémence; Nkoubatchoundjwen, Sandrine; Lum, Ambe A.; Sobngwi, Eugène; Kamgang, René; Boudjeko, Thaddée

doi:10.1155/2021/2452057

Cited by 13 publications

(6 citation statements)

References 42 publications

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“…In comparison to the NC group, the M group showed an increase in all serum parameters, with HDL-C increasing in the HY group and TC, TG, and LDL-C decreasing in the LY and HY groups compared to the M group. Research has shown that increased HDL-C levels and decreased TC and TG levels can reduce the risk of cardiovascular disease [ 25 ]. Therefore, the findings suggest that LH could provide cardiovascular advantages.…”

Section: Resultsmentioning

confidence: 99%

Modulatory Effects of Lactarius hatsudake on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice

Zhu,

Hou

2024

Foods

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Lactarius hatsudake (LH), a great wild endemic fungus, contains rich nutritional components with medicinal properties. The effects of LH on body weight, liver weight, liver injury, blood lipids, and gut microbiota in C57BL/6 mice fed a high-fat diet (HFD) for 8 weeks was examined in this research. Though there was no clear impact on weight loss, the findings indicate that LH treatment effectively decreased liver damage caused by HFD, as well as lowered serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels. Additionally, it positively influenced gut microbiota to resemble that of mice on a normal diet. In HFD-fed mice, LH markedly boosted the levels of Parabacteroides, unclassified Muribaculaceae, Oscillibacter, and unclassified Oscillospiraceae, while reducing the abundance of Lachnospiraceae NK4A136 group and Erysipelatoclostridium, as well as the ratio of Firmicutes to Bacteroidetes. Further analysis of correlation indicate a possible connection between obesity and gut microbiota. Obesity-related indices show a positive association with unclassified Eubacterium coprostanoligenes group, Blautia, and Erysipelatoclostridium, while displaying a negative correlation with unclassified Muribaculaceae, unclassified Clostridia vadinBB60 group, Helicobacter, Oscillibacter, unclassified Ruminococcaceae, Parabacteroides, and unclassified Oscillospiraceae. The results suggest that LH can help combat obesity and may have the potential to be utilized as a functional food.

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Section: Resultsmentioning

confidence: 99%

Modulatory Effects of Lactarius hatsudake on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice

Zhu,

Hou

2024

Foods

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“…Kanwal et al [ 27 ] mixed the fruit body powder of Dictyophora indusiata with boiling water at a ratio of 1:30 ( w / v ) and then extracted it for 2 h to obtain crude polysaccharide (DIP). Mfopa et al [ 28 ] extracted the dried and crushed fruiting body powders of Ganoderma applanatum in boiling water for 3 h and treated them with 95% ethanol at 4 °C for 24 h to obtain polysaccharides. Wang et al [ 29 ] treated the dried Poria cocos Wolf powder with petroleum ether for 24 h at room temperature, extracted them with a ratio of 20:1 (mL/g) in boiling water for 2 h, and then precipitated with four volumes of ethanol at 4 °C to obtain Poria cocos Wolf polysaccharide (PCP-H).…”

Section: Extraction Methods Of Efpsmentioning

confidence: 99%

“…The results showed that TC and TG concentrations in diabetic mice were reduced by 18.8% and 12.0%, respectively, after EPS treatment, and the reduction in LDL-C, HDL-C, and atherogenic index was also observed. Mfopa et al [ 28 ] investigated the antilipidemic potential of Ganoderma applanatum polysaccharides (GAP) in obese rats. The results revealed that GAP intervention could reduce the rate of food intake in obese rats and thus delay the rate of weight gain, and GAP intervention at different doses could significantly reduce TC, TG, and LDL-C levels.…”

Section: In Vivo Bioactivity Of Tfpsmentioning

confidence: 99%

A Review of Development and Utilization for Edible Fungal Polysaccharides: Extraction, Chemical Characteristics, and Bioactivities

Sun

Wang

et al. 2022

Polymers

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Edible fungi, commonly known as mushrooms, are precious medicinal and edible homologous gifts from nature to us. Because of their distinctive flavor and exceptional nutritional and medicinal value, they have been a frequent visitor to people’s dining tables and have become a hot star in the healthcare, pharmaceutical, and cosmetics industries. Edible fungal polysaccharides (EFPs) are an essential nutrient for edible fungi to exert bioactivity. They have attracted much attention because of their antioxidant, immunomodulatory, antitumor, hypoglycemic, and hypolipidemic bioactivities. As a result, EFPs have demonstrated outstanding potential over the past few decades in various disciplines, including molecular biology, immunology, biotechnology, and pharmaceutical chemistry. However, the complexity of EFPs and the significant impact of mushroom variety and extraction techniques on their bioactivities prevents a complete investigation of their biological features. Therefore, the authors of this paper thoroughly reviewed the comparison of different extraction methods of EFPs and their advantages and disadvantages. In addition, the molecular weight, monosaccharide composition, and glycosidic bond type and backbone structure of EFPs are described in detail. Moreover, the in vitro and in vivo bioactivities of EFPs extracted by different methods and their potential regulatory mechanisms are summarized. These provide a valuable reference for improving the extraction process of EFPs and their production and development in the pharmaceutical field.

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“…Therefore, the dietary inclusion of polysaccharides could reduce calorie intake. Moreover, due to their complex special structure, polysaccharides are characterized by great fat-binding capacities, which leads to the increased excretion of dietary or endogenous fatty acids ( 73 ). Polysaccharides can bind bile acids in the intestine to enhance its excretion, thus enabling new bile acid synthesis in the liver and consuming more cholesterol ( 74 ).…”

Section: Polysaccharides Play Vital Roles In the Physiological Status...mentioning

confidence: 99%

Polysaccharides influence human health via microbiota-dependent and -independent pathways

2022

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Polysaccharides are the most diverse molecules and can be extracted from abundant edible materials. Increasing research has been conducted to clarify the structure and composition of polysaccharides obtained from different materials and their effects on human health. Humans can only directly assimilate very limited polysaccharides, most of which are conveyed to the distal gut and fermented by intestinal microbiota. Therefore, the main mechanism underlying the bioactive effects of polysaccharides on human health involves the interaction between polysaccharides and microbiota. Recently, interest in the role of polysaccharides in gut health, obesity, and related disorders has increased due to the wide range of valuable biological activities of polysaccharides. The known roles include mechanisms that are microbiota-dependent and involve microbiota-derived metabolites and mechanisms that are microbiota-independent. In this review, we discuss the role of polysaccharides in gut health and metabolic diseases and the underlying mechanisms. The findings in this review provide information on functional polysaccharides in edible materials and facilitate dietary recommendations for people with health issues. To uncover the effects of polysaccharides on human health, more clinical trials should be conducted to confirm the therapeutic effects on gut and metabolic disease. Greater attention should be directed toward polysaccharide extraction from by-products or metabolites derived from food processing that are unsuitable for direct consumption, rather than extracting them from edible materials. In this review, we advanced the understanding of the structure and composition of polysaccharides, the mutualistic role of gut microbes, the metabolites from microbiota-fermenting polysaccharides, and the subsequent outcomes in human health and disease. The findings provide insight into the proper application of polysaccharides in improving human health.

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Antidyslipidemic Potential of Water-Soluble Polysaccharides of Ganoderma applanatum in MACAPOS-2-Induced Obese Rats

Cited by 13 publications

References 42 publications

Modulatory Effects of Lactarius hatsudake on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice

Modulatory Effects of Lactarius hatsudake on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice

A Review of Development and Utilization for Edible Fungal Polysaccharides: Extraction, Chemical Characteristics, and Bioactivities

Polysaccharides influence human health via microbiota-dependent and -independent pathways

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