Antidyslipidemic effect of a novel vanadium-3-hydroxy flavone complex in streptozotocin-induced experimental diabetes in rats

Pillai, S. Iyyam; Subramanian, S.; Kandaswamy, M.

doi:10.1016/j.bionut.2013.04.004

Cited by 8 publications

(11 citation statements)

References 21 publications

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“…Catechol-like coordination of flavonoid–vanadium complexes are more stable compared with maltol-like and acetylacetone-like coordination under physiological conditions . The vanadium (V IV O 2+ ) complexes of chrysin and morin form pentacoordinated structures with acetylacetone-like coordination. , The same behavior is also reported for other flavonoid–vanadium complexes of apigenin, galangin, kaempferol, and silibinin. , In contrast, the vanadium complex of 3-OH flavone forms neutral hexacoordinated complex with cis -octahedral geometry and maltol like co-ordination with vanadium . Anionic pentacoordinated V IV O complexes exhibiting square pyramidal geometry and catechol-like coordination were formed with 7,8-hydroxyflavone, quercetin, baicalein, fisetin, and rutin .…”

Section: Structural Elucidation Of Vanadium–flavonoid Complexessupporting

confidence: 56%

“…76,77 In contrast, the vanadium complex of 3-OH flavone forms neutral hexacoordinated complex with cisoctahedral geometry and maltol like co-ordination with vanadium. 79 Anionic pentacoordinated V IV O complexes exhibiting square pyramidal geometry and catechol-like coordination were formed with 7,8-hydroxyflavone, quercetin, baicalein, fisetin, and rutin. 71 A similar type of coordination was also observed with luteolin and myricetin−vanadium complexes.…”

Section: Structural Elucidation Ofmentioning

confidence: 99%

“…71 A similar type of coordination was also observed with luteolin and myricetin−vanadium complexes. 71,77,78,79 These variations in the coordination behavior of flavonoid with vanadium are likely to influence their biological activities. Figure 5 depicts the structure of some vanadium complexes of flavonoids that have been deciphered .…”

Section: Structural Elucidation Ofmentioning

confidence: 99%

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Vanadium–Flavonoid Complexes: A Promising Class of Molecules for Therapeutic Applications

Selvaraj

Krishnan

2021

J. Med. Chem.

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Several reports have revealed the superior biological activity of metal ion-flavonoid complexes when compared with the parent flavonoid. Among the different metal ions explored, vanadium and its compounds are in the forefront because of their anticancer and antidiabetic properties. However, the toxicity of vanadium-based ions and their inorganic derivatives limits their therapeutic applications. Complexation of vanadium with flavonoids not only reduces its adverse effects but also augments its biological activity. This Review discusses the nature of coordination in vanadium–flavonoid complexes, their structure–activity correlations, with special emphasis on their therapeutic activities. Several investigations suggest that the superior biological activity of vanadium complexes arise because of their ability to regulate metabolic pathways distinct from those acted upon by vanadium alone. These studies serve to decipher the underlying molecular mechanism of vanadium–flavonoid complexes that can be explored further for generating a series of novel compounds with improved pharmacological and therapeutic performance.

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Section: Structural Elucidation Of Vanadium–flavonoid Complexessupporting

confidence: 56%

Section: Structural Elucidation Ofmentioning

confidence: 99%

Section: Structural Elucidation Ofmentioning

confidence: 99%

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Vanadium–Flavonoid Complexes: A Promising Class of Molecules for Therapeutic Applications

Selvaraj

Krishnan

2021

J. Med. Chem.

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“…Pillaia et al also noted no changes in the level of lipids parameters in nondiabetic rats receiving vanadium-3-hydroxy flavone complex. In turn, in diabetic rats, the same compound showed antidyslipidemic properties [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, the effect of vanadium on carbohydrate metabolism is getting better known, while the effect on lipid metabolism is still a problematic issue. Study indicating dyslipidemic properties of organic complexes of vanadium was conducted in diabetes model [ 6 ]; nevertheless, there is still lack of research evaluating these properties in nondiabetes model. Disturbance of lipid metabolism is a basic factor in development of cardiovascular diseases, which are currently one of the main reasons for mortality [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Bis(4,4′-dimethyl-2,2′-bipyridine)oxidovanadium(IV) Sulfate Dehydrate: Potential Candidate for Controlling Lipid Metabolism?

Francik

Kryczyk-Kozioł

Francik

et al. 2017

BioMed Research International

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Vanadium is a trace element mainly connected with regulation of insulin metabolism which is particularly important in diabetes. In recent years, organic complexes of vanadium seem to be more interesting than inorganic salts. Nevertheless, the effect of vanadium on lipid metabolism is still a problematic issue; therefore, the main purpose of this study was to investigate the effect of 3 organic complexes of vanadium such as sodium (2,2′-bipyridine)oxidobisperoxovanadate(V) octahydrate, bis(2,2′-bipyridine)oxidovanadium(IV) sulfate dehydrate, and bis(4,4′-dimethyl-2,2′-bipyridine)oxidovanadium(IV) sulfate dihydrate in conjunction with high-fat as well as control diet in nondiabetes model on the following lipid parameters: total cholesterol, triglycerides, and high density lipoprotein as well as activity of paraoxonase 1. All of these parameters were determined in plasma of Wistar rats. The most significant effect was observed in case of bis(4,4′-dimethyl-2,2′ bipyridine)oxidovanadium(IV) sulfate dehydrate in rats fed with high-fat diet. Based on our research, bis(4,4′-dimethyl-2,2′-bipyridine)oxidovanadium(IV) sulfate dihydrate should be the aim of further research and perhaps it will be an important factor in the regulation of lipid metabolism.

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Vitamin D3 prevents the increase in ectonucleotidase activities and ameliorates lipid profile in type 1 diabetic rats

et al. 2015

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This study was designed to assess the potential effect of vitamin D3 (VD3) in avoiding atherothrombosis by modulation of lipid metabolism and platelet activation in type 1 diabetic rats. Male wistar rats were divided into eight groups (n = 5-10): Control/Saline (Sal); Control/Metformin 500 mg/kg (Metf); Control/Vitamin D3 90 µg/kg (VD3); Control/Metformin 500 mg/kg + VD3 90 µg/kg (Metf + VD3); Diabetic/Saline (Sal); Diabetic/Metformin 500 mg/kg (Metf); Diabetic/Vitamin D3 90 µg/kg (VD3); Diabetic/Metformin 500 mg/kg + VD3 90 µg/kg (Metf + VD3). Treatments were administered during 30 days after diabetes induction with streptozotocin (STZ). After 31 days, the rats were euthanized and blood was collected and separated into serum and platelets, both used for lipid profile and ectonucleotidase activity assays, respectively. Ectonucleoside triphosphate phosphohydrolase (E-NTPDase), ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP), and 5'-nucleotidase and adenosine deaminase (E-ADA) were significantly higher in the Diabetic than in Control group. Treatment with Metf and/or VD3 prevented the increase in NTPDase and E-NPP activities in diabetic rats. Only Metf + VD3 significantly prevented the increase in 5'-nucleotidase. VD3 alone, but not Metf, prevented the increase in ADA activity when compared to saline-treated diabetic rats. Treatment of rats with VD3, Metf, and Metf + VD3 was also effective in the prevention of lipid metabolism disorder in diabetic and was able to ameliorate lipid metabolism in non-diabetic rats. These results provide evidence for the potential of Metf and VD3 in the treatment of platelet dysfunction and lipid metabolism impairment in T1D, which may be important in the control and prevention of atherothrombosis in diabetes.

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Antidyslipidemic effect of a novel vanadium-3-hydroxy flavone complex in streptozotocin-induced experimental diabetes in rats

Cited by 8 publications

References 21 publications

Vanadium–Flavonoid Complexes: A Promising Class of Molecules for Therapeutic Applications

Vanadium–Flavonoid Complexes: A Promising Class of Molecules for Therapeutic Applications

Bis(4,4′-dimethyl-2,2′-bipyridine)oxidovanadium(IV) Sulfate Dehydrate: Potential Candidate for Controlling Lipid Metabolism?

Vitamin D3 prevents the increase in ectonucleotidase activities and ameliorates lipid profile in type 1 diabetic rats

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