Antidyslipidemic and antioxidant activities of different fractions ofTerminalia arjuna stem bark

Abstract

Terminalia aquna (T. aduna) stem bark was successively extracted with petroleum ether (A), solvent ether (B), ethanol (C) and water (D). The lipid lowering activity of these four fractions A, B, C, and D was evaluated in vivo in two models viz., triton WR-1339 induced hyperlipemia in rats as well as fructose rich high fat diet (HFD) fed diabetic-dyslipidemic hamsters. Hyperlipidemia induced by triton caused marked increase in the plasma levels of total cholesterol (-Fc), triglyceride (Tg) and phospholipids (PL) in rats. After treatment with T. a~una fractions A, B, C, and D at the doses of 250 mg/kg per oral (p.o.), only the ethanolic fraction (C) exerted significant lipid lowering effect as assessed by reversal of plasma levels of Tc, Tg and PL in hyperlipidemic rats. In another experiment, feeding with HFD produced marked dyslipidemia as observed by increased levels of plasma Tc, Tg, glucose (Glu), glycerol (Gly) and free fatty acids (FFA) in hamsters. After treatment with T. arjuna fractions at the doses of 250 mg/kg p.o. only two fractions (B and C) could exert significant lowering in the plasma levels of lipids and Glu. in dyslipidemic hamsters. In vitro experiment T. arjuna fractions at tested concentrations (50-500 pg/ml) inhibited the oxidative degradation of lipids in human low density lipoprotein and rat liver microsomes induced by metal ions. These fractions when tested against generation of oxygen free radicals at the concentrations (50-500 iglml), counteracted the formation of superoxide anions (0 2) and hydrodyl radicals (OH) in non enzymic test systems. The efficacy of T. a~una fractions as antidysiipidemic and antioxidant agents was found, fraction C> fraction B> fraction A. KEY WORDSAntidyslipidemic activity, antioxidant activity, Terminalia arjuna oxygen free radical, triton model, hamster model.

Antimicrobial activity ofTerminalia bellerica

“…Recently it has been found that T. chebula at a dose of 200 mg/kg body weight improved the glucose tolerance by reducing 44% of reduction in the peak blood glucose at 2 nd hour of glucose tolerance test (10). The antidyslipidemicand antioxidant activity of Terminalia arjuna stembark has also been reported recently (11). It was evident from this study that T. bellerica fruit extract can be used against fever, superficial skin infections, urinary tract and diarrheal infections.…”

Naringenin and quercetin – potential anti-HCV agents for NS2 protease targets

“…Phytomedicines play a critical role in curing the liver diseases and in curbing the side effects of synthetic drugs. Some of those plants are Andrographis paniculata, Terminalia arjuna, Tinospora cordiofolia, Picrorhiza kurroa, Eclipta alba and Cichorium intibys and their phytocompounds are andrographolide (Handa & Sharma 1990), arjunic acid (Chander et al 2004), berberine, chasmanthin, desmethylwedelolactone and esculetin, respectively. Berberine from Tinospora cordiofolia (Zhao et al 2008), chasmanthin derived from Picrorhiza kurroa (Rahim et al 2012 Eclipta alba commonly known as bringaraja (Wagner et al 1986), Esculetin from Cichorium intybus commonly known as chicory, (Chang et al 1994;Heibatollah et al 2008), silymarin, honokiol, naringenin, quercetin were found to treat inflammation and HCV infection.…”

Immunomodulatory Potential of Gemmomodified Extract of Terminalia arjuna

“…Terminalia arjuna is versatile traditional medicinal plant Clinical studies suggested that T. arjuna is effective in patient of stable angina 16 . It improves the blood circulation to heart, regulate blood pressure 17 used for treatment of hypercholesterolemia 15,[18][19] and inhibited the platelet aggregation 20 . Little work has been done on immunomodulatory activity of Terminalia arjuna.It is need of time to develop alternative therapies for treatment of immune disease therefore, this project has been designed to explore the important immunomodulatory potential of gemmomodified and bark extracts of Terminalia arjuna.…”