Antidiarrhoeal activity of Waltheria americana, Commelina coelestis and Alternanthera repens

Zavala, Miguel; Pérez, Salud; Pérez, Cuauhtémoc; Vargas, Rubem Mário Figueiró; Pérez, Raúl Mengana

doi:10.1016/s0378-8741(98)00014-2

Cited by 73 publications

(52 citation statements)

References 5 publications

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“…3 and 4), that have been identified from the lipophilic fraction are tabulated (Table 2). Eighteen saturated [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] and four unsaturated [19][20][21][22] hydrocarbons, ten saturated [23][24][25][26][27][28][29][30][31][32] cholesterol homologues and it is reported that lowdoses of phytosterol-supplementation has produced significantly lowered plasma total cholesterol 22 . Such lipid-lowering effect of phytosterols is claimed to be mediated by competitive inhibition of cholesterol absorption and by transcriptional induction of genes implicated in cholesterol metabolism in both enterocytes and hepatocytes.…”

Section: Separation and Identification Of The Lipophilic Metabolitesmentioning

confidence: 99%

“…A. brasiliana, A. philoxeroides, A. pungens, A. sessilis and A. tenella have been pharmacologically investigated [5][6][7][8][9][10][11][12][13] to exhibit antiviral (HSV-1 and HIV), antihistaminic, anticarcinogenic, antileukaemic, antiulcer, antihepatotoxic and diuretic activities. A. philoxeroides Griseb is being prescribed clinically in the People's Republic of China for the treatment of viral hepatitis, epidemic parotitis, hemorrhagic fever and influenza.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Capacity and Lipophilic Constitution of Alternanthera bettzickiana Flower Extract

Petrus¹,

Kalpana²,

Devi³

2014

Orient. J. Chem.

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Section: Separation and Identification Of The Lipophilic Metabolitesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Capacity and Lipophilic Constitution of Alternanthera bettzickiana Flower Extract

Petrus¹,

Kalpana²,

Devi³

2014

Orient. J. Chem.

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“…They have been established to be frequently responsible for most medicinal plants. It is well documented that castor oil produced diarrhoea due to ricinoleic action which stimulate peristaltic (contraction) activity in the small intestine leading to hyper secretory response and electrolytes permeability changes in intestinal mucosa 9,26 . Loperamide inhibits gastrointestinal motility by effects on circular and longitudinal muscles of the intestine.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Methanolic Extract of Anogeissus Leiocarpus Stem Bark on Castor Oil- Induced Diarrhoea in Rats

2017

JCBSC

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Diarrhoea has been a major cause of morbidity and mortality especially among children in developing countries. Anogeissus leiocarpus (Combretaceae) has been reported to possess a number of medicinal properties. The purpose of the present study was to evaluate effects of methanolic extract of A. leiocarpus stem bark on castor oil-induced diarrhoea model in rats. Rats were divided into four groups of five in each and treated. Group I (distilled water), group II (200mg/kg extract), group III (400mg/kg) and group IV Loperamide (2mg/kg). All treatments were orally administered for effects on intestinal motility, fluid accumulation and electrolytes secretion pre and post administration of extract and their respective percentages expressed relative to experimental control. Methanol 10.67%. The preliminary phytochemical screening revealed the presence of tannins, saponins, flavonoids, terpenes, alkaloids and glycosides. 200 and 400mg/kg methanolic extract significantly (P<0.05) inhibited motility by 41.11% and 51.32% respectively, and fluid accumulation was reduced by 39.45% and 57.87%. The study also revealed progressive diminution of Na + and K + concentrations in stool. There were significant reductions, (P<0.05) in frequency of wet stool, with lower curatives values of 10.00% and 24.00% than preventive values of 20.79% and 44.99%. The presence of some of the phytochemicals in the extracts may be responsible for the observed activities and attest to its utility in a wide range of diarrhoeal states. Further research to be carried on monitored fractionation and subsequent structural elucidation with a view to understanding the compound and possible mechanism of action.

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“…The extracts reduced this diarrhea probably through the inhibition of prostaglandin biosynthesis. On the other hand, magnesium sulphate accelerates the liberation of cholecystokinin from duodenal mucosa, which extends the secretion and motility of small intestine [33]. The extracts reduced the diarrheia, perhaps by increasing the absorption of water and electrolyte from GIT.…”

Section: Discussionmentioning

confidence: 99%

Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of <i>Dimocarpus longan</i> Lour in Rats

Ripa¹,

Morshed²,

Sharmin³

et al. 2014

Trop. J. Pharm Res

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Antidiarrhoeal activity of Waltheria americana, Commelina coelestis and Alternanthera repens

Cited by 73 publications

References 5 publications

Antioxidant Capacity and Lipophilic Constitution of Alternanthera bettzickiana Flower Extract

Antioxidant Capacity and Lipophilic Constitution of Alternanthera bettzickiana Flower Extract

Evaluation of Methanolic Extract of Anogeissus Leiocarpus Stem Bark on Castor Oil- Induced Diarrhoea in Rats

Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of <i>Dimocarpus longan</i> Lour in Rats

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