Antidiarrhoeal activity of leaves ofMelastoma malabathricumlinn

Abstract

The antidiarrhoeal effect of the water extract of Melastoma malabathricum Linn. (Melastomataceae) leaves were investigated by employing four experimental models of diarrhea in Swiss mice. Melastoma malabathricum water extract treated mice showed significant reduction in the fecal output and protected them from castor oil-induced diarrhoea. The extract also reduced the intestinal fluid secretion induced by magnesium sulphate and gastrointestinal motility after charcoal meal administration in the mice. No mortality and visible signs of general weakness was observed in the mice following the test extract administration up to 2000 mg/kg dose.

RETRACTED ARTICLE: Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response

“…Researchers have proved the antinociceptive, anti-inflammatory, antipyretic [15, 16], antidiarrhoeal [17], antimicrobial [18], antiproliferative and antioxidant [19], antiulcer activity [20], acute toxicity evaluation, antibacterial, antioxidant and immunomodulatory effects and hepatoprotective activity [21, 22] of the plant. However, this plant is not scientifically explored for its antiarthritic activity.…”

Phytochemical Analysis and Constituents of Hexane Extract of Melastoma Malabathricum L

“…Detailed literature review indicated that various classes of phytochemicals have been identified in different parts of M. malabathricum such as fatty acids and aliphatic constituents (Dinda & Saha 1986a, Dinda & Saha 1986b, Dass & Kotoky 1988, sterols (Manzoor-I-Khuda et al 1981), phenolic acids (Lowry 1968), flavonoids and their glycosides (Dinda & Saha 1988, Mohandoss & Ravindran 1993, Wong et al 2012, tannins (Yoshida et al 1992a(Yoshida et al , 1992b, anthocyanins (Lowry 1976), amino acids (Dinda & Saha 1985) and so on. Different parts of the plant have been shown to exert diverse biological activities like antibacterial and antifungal (Grosvenor et al 1995, Wiart et al 2004, Johnny et al 2010, Maji et al 2010), cytotoxic (Susanti et al 2007 and antiviral (Nazlina et al 2008, Lohezic-Le Devehat et al 2002, antiparasitic (Alen et al 2000), antioxidant (Susanti et al 2007, anticoagulant (Manicam et al 2010), platelet-activating factor inhibitory (Jantan et al 2005), wound healing (Sunilson et al 2008), anti-ulcer (Hussain et al 2008), anti-diarrheal (Sunilson et al 2009), anti-nociceptive (Sulaiman et al 2004), and anti-pyretic (Zakaria et al 2006) at different concentrations.…”

Antinociception of petroleum ether fraction derived from crude methanol extract of Melastoma malabathricum leaves and its possible mechanisms of action in animal models

“…Locally known to the Malay as “ Senduduk ”, M. malabathricum has been used in the Malay traditional medicines to treat ailments such as stomach ulcers, dysentery and diarrhoea, those associated with pain (i.e., toothache and stomachache), to accelerate wound healing, for post-natal care and prevention of scars from small pox infection, and postpartum remedy [15–19]. Scientifically, the leaves of M. malabathricum have been reported to exert no acute toxicity [20] and, antibacterial [20, 21], antiviral [20], antioxidant [22], cytotoxic [22], anti-inflammatory [23, 24], anticoagulant [25], antiulcer [26], antidiarrheal [20], antinociceptive [16, 24] and antipyretic [24] activities.…”