Antidiarrhoeal Activity of Chromatographic Fractions of Stereospermum kunthianum Cham Sandrine Petit (Bignoniaceae) Stem Bark

Abstract

Purpose: The present study was undertaken in order to evaluate the antidiarrhoeal activity of three chromatographic fractions (L, S and Y)

Nanocapsulated Rift Valley Fever Vaccine Candidates and Relative Immunological and Histopathological Reactivity in Out Bred Swiss Mice

“…While, BPL is auto hydrolysed into propionic acid and water and its derivatives are safe, so why it is used in human vaccine production [25][26][27][28][29][30][31][32][33][34][35][36][37]. Concerning safety of chemical inactivants, it was a must, to assure the safety measure of prepared vaccine this was in accordance to [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Adjuvants have been necessary to improve vaccine efficacy in order to afford protection against infections.…”

“…Toxicity of ascorbic acid (1.5 mg /ml), 0.2 % formaldehyde solution neutralized with Nabisulphite and 0.0035 M Beta-propiolactone was determined [26].…”

Phytochemical and Antibacterial Properties of Leaf Extract of Stereospermum kunthianum (Bignoniaceae)

“…Previously, the antiplasmodial activities of naphthaquinones and one anthraquinone from the lipophilic root bark extract was reported (Onegi et al, 2002). Antidiarrhoeal (Ching et al, 2008), analgesic activities of stem bark (Ching et al, 2009), as well as the anthelmintic activity of ethanol leave extract has been reported (Monglo et al, 2006).The present study therefore, reports the phytochemical screening and antibacterial activity of the lipophilic leaves extract of Stereospermum kunthianum with a view to understanding the molecular basis of some of its therapeutic uses in traditional medicine, which had not been investigated hitherto.…”

Aqueous stem bark extract of <i>Stereospermum kunthianum </i> (cham, sandrine petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents.

“…Among its traditional medical uses is the use in the management of seizures in infants and young children. We have recently demonstrated the antidiarrhoeal activity of the aqueous extract of Stereospermum kunthianum stem bark in in-vivo experimentally -induced diarrhoeal models using mice and rats (Ching et al, 2008). The efficacy of the water extract of Stereospermum kunthianum in human complement system fixation in-vitro has been reported (Drissa et al, 2002).…”