Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats

Sebaï, Hichem; Jabri, Mohamed-Amine; Souli, Abdelaziz; Rtibi, Kaïs; Selmi, Slimen; Tebourbi, Olfa; El-Benna, Jamel; Sakly, Mohsen

doi:10.1016/j.jep.2014.01.015

Cited by 108 publications

(75 citation statements)

References 49 publications

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“…However, we can now suggest that LSEO exert beneficial effects by scavenging H 2 O 2 leading to antioxidant properties, as recently described by Souli et al 47 Further experiments are needed to assess the effect of LSEO on labile iron levels, known for its implication in the H 2 O 2 -mediated oxidative injury through its participation in the Fenton pathway. 48 …”

Section: Figmentioning

confidence: 99%

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Selmi

Jallouli²,

Gharbi³

et al. 2015

Journal of Medicinal Food

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We aimed in the present study to investigate the hepato-and nephroprotective effects of Lavandula stoechas essential oils (LSEO) against malathion-induced oxidative stress in young male mice as well as the possible mechanism implicated in such protection. Animals were divided into eight groups of 12 each: Control, malathion (200 mg/kg b.w.); Various doses of LSEO (10, 30, and 50 mg/kg b.w.), malathion + various doses of LSEO. Malathion and LSEO were daily per orally (p.o.) administered by intragastric gavage during 30 days. We initially found that malathion treatment induced body weight gain decrease as well as a clear nephro-and hepatotoxicity as assessed by significant relative liver and kidney weight increase and related hemodynamic parameters deregulation. Malathion exposure of mice also induced a considerable perturbation of metabolic parameters. On the other hand, we showed that malathion administration was accompanied by an oxidative stress status assessed by an increase of malondialdehyde (MDA) and hydrogen peroxide (H2O2) levels as well as a depletion of sulfhydril group content (-SH) and antioxidant enzyme activities such as catalase (CAT) and glutathione peroxidase (GPx), total superoxide dismutase (SOD), Cu/Zn-SOD, Mn-SOD, and Fe-SOD in the kidney and liver. More importantly, LSEO treatment abolished all malathion-induced body gain loss, liver and kidney relative weight increase, hemodynamic and metabolic disorders, as well as hepatic and renal oxidative stress. In conclusion, our data suggest that LSEO exerted potential hepato-and nephroprotective effects against malathion-induced oxidative stress in mice. The beneficial effect of LSEO might be related, in part, to its antioxidant properties.

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Section: Figmentioning

confidence: 99%

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Selmi

Jallouli²,

Gharbi³

et al. 2015

Journal of Medicinal Food

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“…Anti-diarrheal activity: Anti-diarrheal activity was evaluated by using castor oil induced method in mice (Agbor et al, 2014;Sebai et al, 2014). Sixteen Swiss albino mice were randomly divided into four groups (n=4).…”

Section: Methodsmentioning

confidence: 99%

Analgesic and anti-diarrheal activities of Aganosma dichotoma (Roth) K. Schum. in Swiss-albino mice model

et al. 2015

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Aganosma dichotoma (Roth) K. Schum. is an indigenous plant of Bangladesh. Traditional healers use this plant to treat many diseases. In order to systematically explore the medicinal values of this plant, the crude methanol extract of leaves of A. dichotoma were screened for analgesic and antidiarrheal activities in mice model. The peripheral and central analgesic actions were determined by using acetic acid-induced writhing and tail immersion methods. The extract significantly (p < 0.05) attenuated the acetic acid-induced writhing in a dose dependent manner. A noticeable dose-dependent increase (p < 0.05) of latency period was also observed in the tail immersion method. In the castor oil induced anti-diarrheal assay, the extract exhibited significant (p < 0.05) anti-diarrheal effect at a dose of 400 mg/kg body weight.

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“…It has a long history of being used as a medicinal plant due to many health benefits, including anti-inflammatory, anticancer, antispasmodic, radical-scavenging effects and others [1]. Moreover, chamomile extract was shown to have a potent antidiarrheal and antioxidant properties in rats confirming their use in traditional medicine [2]. In 2008, Khan and colleagues indicated that chamomile tea possesses a glucose lowering effect in diabetic rats, other researchers confirmed the ability of chamomile to progressively reduce the fasting and post prandial blood sugar levels as well as lowering the level of hemoglobin A1c (HbA1c) significantly suggesting a possible potential in type 2 diabetes management and recommending its daily consumption as a potentially useful tool in hyperglycemia control [3,4].…”

Section: Commentarymentioning

confidence: 98%

Chamomile Tea Potentials in Prevention and Amelioration of Type 2 Diabetes Mellitus

Kelleni¹

2016

J Diabetes Metab

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Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats

Cited by 108 publications

References 49 publications

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Analgesic and anti-diarrheal activities of Aganosma dichotoma (Roth) K. Schum. in Swiss-albino mice model

Chamomile Tea Potentials in Prevention and Amelioration of Type 2 Diabetes Mellitus

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