Antidiarrheal activity of ethanolic extract of Manihot esculenta Crantz leaves in Wistar rats

Bahekar, Satish E; Kale, Ranjana S

doi:10.4103/0975-9476.146542

Cited by 31 publications

(25 citation statements)

References 21 publications

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“…Moreover, many international organizations including WHO have encouraged studies pertaining to the treatment and prevention of diarrheal diseases using traditional medical practices [ 7 – 9 ]. At present, around 25% of drugs are isolated from plants and there are numerous evidences available about the use of medicinal plants including their pharmacological and biochemical properties [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antidiarrheal Activity of Methanolic Extract ofMaranta arundinaceaLinn. Leaves

Rahman

Chowdhury

Islam

et al. 2015

Advances in Pharmacological Sciences

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Diarrhea is one of the most common causes for thousands of deaths every year. Therefore, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research. Our aim was to investigate the antidiarrheal and cytotoxic activities of methanolic extract of Maranta arundinacea linn. (MEMA) leaves in rats and brine shrimp, respectively. Antidiarrheal effect was evaluated by using castor oil-induced diarrhea, enteropooling, and gastrointestinal motility tests at 200 mg/kg and 400 mg/kg body weight in rats where the cytotoxic activity was justified using brine shrimp lethality bioassay at different concentrations of MEMA. The extract showed considerable antidiarrheal effect by inhibiting 42.67% and 57.75% of diarrheal episode at the doses of 200 and 400 mg/kg, respectively. MEMA also significantly (p < 0.01) reduced the castor oil-induced intestinal volume (2.14 ± 0.16 to 1.61 ± 0.12 mL) in enteropooling test as well as intestinal transit (33.00 to 43.36%) in GI motility test, compared to their respective control. These observed effects are comparable to that of standard drug loperamide (5 mg/kg). On the other hand, in brine shrimp lethality test after 24 h, surviving brine shrimp larvae were counted and LD50 was assessed. Result showed that MEMA was potent against brine shrimp with LD50 value of 420 µg/mL. So the highest dose of 400 µg/mL of MEMA was not toxic to mice. So these results indicate that bioactive compounds are present in methanolic extract of Maranta arundinacea leaves including significant antidiarrheal activity and could be accounted for pharmacological effects.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Antidiarrheal Activity of Methanolic Extract ofMaranta arundinaceaLinn. Leaves

Rahman

Chowdhury

Islam

et al. 2015

Advances in Pharmacological Sciences

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“…Epple et al [23] reported that loperamide exerted anti-secretory effect in the colonic epithelial cells (HT-29/B6) stimulated with forskolin. Loperamide entailed the reduction of intestinal fluid volume accumulation after ig administration of castor oil in rats [24]. Interestingly, Cai et al [25] examined the effect of endomorphin analogues on forskolin-stimulated cAMP production in HEK-293 cells (expressing all ORs) and compared the results to reference ORs agonists.…”

Section: Discussionmentioning

confidence: 99%

Methyl-orvinol—Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome

Zielińska

Jarmuż

Wasilewski

et al. 2017

Pharmacological Reports

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Background Diarrhea-predominant irritable bowel syndrome (IBSD) is a functional disorder of the gastrointestinal (GI) tract. The major IBS-D symptoms include diarrhea, abdominal pain and discomfort. High density of opioid receptors (ORs) in the GI tract and their participation in the maintenance of GI homeostasis make ORs ligands an attractive option for developing new anti-IBS-D treatments. The aim of this study was to characterize the effect of methyl-orvinol on the GI motility and secretion and in mouse models mimicking symptoms of IBS-D. Materials and methods In vitro, the effect of methyl-orvinol on electrical field stimulated smooth muscle contractility and epithelial ion transport were characterized in the mouse colon. In vivo, the following tests were used to determine methyl-orvinol effect on mouse GI motility: colonic bead expulsion, whole GI transit and fecal pellet output. An antinociceptive action of methyl-orvinol was assessed in the mouse model of visceral pain induced by mustard oil. Results Methyl-orvinol (10-10 – 10-6 M) inhibited colonic smooth muscle contractions in a concentration-dependent manner. This effect was reversed by naloxone (non-selective opioid antagonist) and β-funaltrexamine (selective MOP antagonist). Experiments with a selective KOP receptor agonist, U50488 revealed that methyl-orvinol is a KOP receptor antagonist in the GI tract. Methyl-orvinol enhanced epithelial ion transport. In vivo, methyl-orvinol inhibited colonic bead expulsion and prolonged GI transit. Methyl-orvinol improved hypermotility and reduced abdominal pain in the mouse models mimicking IBS-D symptoms. Conclusion Methyl-orvinol could become a promising drug candidate in chronic therapy of functional GI diseases such as IBS-D.

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“…In addition, the inhibition of gut motility can be explained on the basis of presence of alkaloids in the plant, which have been reported to possess anticholinergic property. 17…”

Section: Compounds With Diarrhea-management Actionmentioning

confidence: 99%

Laxative and anti-purgative bioactive compounds in prevention and treatment of functional gastrointestinal disorders, constipation and diarrhea

Rtibi¹

2018

JNHFE

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Normal gastrointestinal functions include transport, digestion, and absorption of nutrients, and removal of waste products. Functional gastrointestinal disorders are characterized by current gastrointestinal disruptions that have opposite pathophysiologic mechanisms such as dismotility and diarrhea. Patients with FGIDs experience a constellation of symptoms consistent with abnormalities in these gastrointestinal functions. 1 Constipation pathogenesis Constipation or intestinal dismotility is an acute or chronic gastrointestinal pathology characterized by infrequent and limited bowel movements, hard and dry stools, inadequate and insufficient bowel evacuation and difficulty in elimination of defecation. 2 Pathophysiology of diarrhea Diarrhea is an increase in the volume of stool or frequency of defecation. The absorption/secretion process of water and electrolytes throughout the gastrointestinal tract is a finely balanced, dynamic process and, imbalance phenomen caused either by decreased absorption or increased secretion, diarrhoea results. 3 A recent study showed that sulphated polysaccharide isolated from the Seaweed Gracilaria caudata more effectively reduced diarrhoea

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Antidiarrheal activity of ethanolic extract of Manihot esculenta Crantz leaves in Wistar rats

Cited by 31 publications

References 21 publications

Evaluation of Antidiarrheal Activity of Methanolic Extract ofMaranta arundinaceaLinn. Leaves

Evaluation of Antidiarrheal Activity of Methanolic Extract ofMaranta arundinaceaLinn. Leaves

Methyl-orvinol—Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome

Laxative and anti-purgative bioactive compounds in prevention and treatment of functional gastrointestinal disorders, constipation and diarrhea

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