Antidiabetic Potentials of Button Mushroom (Agaricus bisporus) on Alloxan-Induced Diabetic Rats

Ekowati, Nuraeni; Yuniati, Nilasari Indah; Hernayanti, Hernayanti; Ratnaningtyas, Nuniek Ina

doi:10.15294/biosaintifika.v10i3.17126

Cited by 15 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier studies show that mushrooms are rich in ß-D-glucans, ß-glucan, a type of dietary fiber that shows promising health benefits against T2DM [80]. Mushroom extracts from Pleurotus species [56], Boletu [58], Grifola frondosa [81], Agaricus bisporus [38], Hericium erinaceus [63], and Ganoderma lucidum [82] regulate the synthesis of glycogen and lowers blood glucose levels by regulating gene expression of glycogen synthase kinase (GSK-3 ß), glycogen synthase (GS) and glucose transporter 4 (GLUT4) in liver and muscle. Therefore GSK-3 ß could be identified as an insulin-mediated GSregulated negative regulator [83].…”

Section: Blood Glucose-lowering Effect Of Polysaccharidementioning

confidence: 99%

See 1 more Smart Citation

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Das

Chen

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

Mushrooms belong to the family “Fungi” and became famous for their medicinal properties and easy accessibility all over the world. Because of its pharmaceutical properties, including anti-diabetic, anti-inflammatory, anti-cancer, and antioxidant properties, it became a hot topic among scientists. However, depending on species and varieties, most of the medicinal properties became indistinct. With this interest, an attempt has been made to scrutinize the role of edible mushrooms (EM) in diabetes mellitus treatment. A systematic contemporary literature review has been carried out from all records such as Science Direct, PubMed, Embase, and Google Scholar with an aim to represents the work has performed on mushrooms focuses on diabetes, insulin resistance (IR), and preventive mechanism of IR, using different kinds of mushroom extracts. The final review represents that EM plays an important role in anticipation of insulin resistance with the help of active compounds, i.e., polysaccharide, vitamin D, and signifies α-glucosidase or α-amylase preventive activities. Although most of the mechanism is not clear yet, many varieties of mushrooms’ medicinal properties have not been studied properly. So, in the future, further investigation is needed on edible medicinal mushrooms to overcome the research gap to use its clinical potential to prevent non-communicable diseases.

show abstract

Section: Blood Glucose-lowering Effect Of Polysaccharidementioning

confidence: 99%

“…Several studies have proven that mushrooms, especially Pleurotus spp. [56], Grifola frondosa [81], Agaricus bisporus [38], Hericium erinaceus [63], and Ganoderma lucidum [65] have significant blood glucose-lowering effect, as they delay the absorption of glucose and therefore improves hyperglycaemic condition [78].…”

Section: Inhibition Of Glucose Absorptionmentioning

confidence: 99%

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Das

Chen

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Mushrooms have been found to have high concentrations of β-D-glucans, especially β-glucan, a form of dietary fiber that has shown positive effects in combating type 2 diabetes [ 112 ]. Gene expression of glycogen synthase kinase (GSK-3 β), glycogen synthase (GS), and glucose transporter 4 (GLUT4) in the liver and muscle is regulated by mushroom extracts from Pleurotus species [ 49 ], Agaricus bisporus [ 54 ], Ganoderma lucidum [ 113 ], etc., leading to decreased blood glucose levels. As a result, GS kinase 3 beta (GSK-3 β) could be a negative regulator of GS mediated by insulin [ 114 ].…”

Section: The Preventive Mechanistic Approach Of Mushrooms Against Dia...mentioning

confidence: 99%

“…Multiple studies have shown that mushrooms, particularly Pleurotus spp. [ 49 ], A. bisporus [ 54 ], and G. lucidum [ 59 ], significantly reduce blood glucose levels by delaying the body’s absorption of glucose [ 110 ].…”

Section: The Preventive Mechanistic Approach Of Mushrooms Against Dia...mentioning

confidence: 99%

Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment

et al. 2023

View full text Add to dashboard Cite

Diabetes mellitus is a complex illness in which the body does not create enough insulin to control blood glucose levels. Worldwide, this disease is life-threatening and requires low-cost, side-effect-free medicine. Due to adverse effects, many synthetic hypoglycemic medications for diabetes fail. Mushrooms are known to contain natural bioactive components that may be anti-diabetic; thus, scientists are now targeting them. Mushroom extracts, which improve immune function and fight cancer, are becoming more popular. Mushroom-derived functional foods and dietary supplements can delay the onset of potentially fatal diseases and help treat pre-existing conditions, which leads to the successful prevention and treatment of type 2 diabetes, which is restricted to the breakdown of complex polysaccharides by pancreatic-amylase and the suppression of intestinal-glucosidase. Many mushroom species are particularly helpful in lowering blood glucose levels and alleviating diabetes symptoms. Hypoglycaemic effects have been observed in investigations on Agaricussu brufescens, Agaricus bisporus, Cordyceps sinensis, Inonotus obliqus, Coprinus comatus, Ganoderma lucidum, Phellinus linteus, Pleurotus spp., Poria cocos, and Sparassis crispa. For diabetics, edible mushrooms are high in protein, vitamins, and minerals and low in fat and cholesterol. The study found that bioactive metabolites isolated from mushrooms, such as polysaccharides, proteins, dietary fibers, and many pharmacologically active compounds, as well as solvent extracts of mushrooms with unknown metabolites, have anti-diabetic potential in vivo and in vitro, though few are in clinical trials.

show abstract

“…In addition, mushrooms have been described to possess beneficial health effects such as gut microbiota modulation [10,11], reduction in brain oxidative stress [10], anti-obesogenic effects and liver steatosis prevention [12,13], anti-cancer [14,15], anti-inflammatory [16][17][18], and antimicrobial [19][20][21], among others [6][7][8]. Moreover, they have antioxidant, anti-hyaluronidase, anti-tyrosinase, anti-elastase, and anti-collagenase activity, making them suitable for use as cosmetic ingredients [22].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antibacterial, and Cosmeceutical Potential of Four Common Edible Mushrooms

et al. 2023

View full text Add to dashboard Cite

Waste generated in mushroom cultivation represents a valuable raw material with health benefits, the use of which contributes to a reduction in food waste and to the circular economy. Hydroethanolic extracts obtained by ultrasound-assisted extraction of four edible mushroom species (Agaricus bisporus var. Portobello, Boletus edulis, Lentinula edodes, and Pleurotus ostreatus) were characterized according to their antioxidant, antibacterial, and cosmeceutical potential. The extract with the best properties was incorporated into a cosmetic cream. Concerning the phenolic contents and antioxidant capacity, the extracts of A. bisporus and B. edulis stood out from the other two due to their higher levels. The compounds p-hydroxybenzoic and gallic acids were present in all mushrooms in the ranges of 0.010 to 2.554 µg/g DW and 0.032 to 0.112 µg/g DW, respectively. The extract of B. edulis inhibited all the bacterial isolates, with minimum inhibitory concentration values ranging from 5 to 20 mg/mL for Gram-positive and 10–20 mg/mL for Gram-negative strains. In the anti-hyaluronidase assay, A. bisporus extract (10 mg/mL) was the most effective, with 74.4 ± 7.5% enzyme inhibition, and was selected for incorporation into the cosmetic cream. The cream with A. bisporus extract showed significantly higher phenolic contents and antioxidant capacity than the cream without the extract. Overall, our results support the high value of mushroom reuse as a source of natural antioxidants in the cosmetic industry.

show abstract

Antidiabetic Potentials of Button Mushroom (Agaricus bisporus) on Alloxan-Induced Diabetic Rats

Cited by 15 publications

References 28 publications

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment

Antioxidant, Antibacterial, and Cosmeceutical Potential of Four Common Edible Mushrooms

Contact Info

Product

Resources

About