Antidiabetic potential of methanolic and flavonoid-rich leaf extracts of Synsepalum dulcificum in type 2 diabetic rats

Obafemi, Tajudeen Olabisi; Akinmoladun, Afolabi Clement; Olaleye, Mary Tolulope; Agboade, Stephen O.; Onasanya, A.

doi:10.1016/j.jaim.2017.01.008

Cited by 46 publications

(34 citation statements)

References 35 publications

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“…Studies have demonstrated flavonoids have a promising role preventing obesity-related diabetic complications due to their effectiveness increasing insulin secretion, reducing insulin resistance, and inhibiting hormone-sensitive lipase activity (Obafemi et al. 2017 ; Liu et al. 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia

Aloud

Veeramani

Govindasamy

et al. 2018

Pharmaceutical Biology

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Context: Galangin, a natural flavonoid, is found in honey and Alpinia officinarum Hance (Zingiberaceae). Galangin has antiviral, antimicrobial, antidiabetic and anticancer properties, without side effects. The effects of galangin on hyperglycaemia and lipid abnormalities are not known.Objective: To elucidate the effectiveness of galangin on hyperglycaemia-associated complications and lipid changes in rats with streptozotocin (STZ)-induced hyperglycaemia.Materials and methods: Diabetes was induced in adult Wistar rats by administering 40 mg/kg of STZ. In our previous study, galangin had no toxicity at concentrations up to 320 mg/kg. Therefore three doses of galangin (4, 8 or 16 mg/kg BW) or glibenclamide (600 µg/kg BW) were administered daily to diabetic rats orally for 45 days.Results: Diabetic rats showed a significant (p < 0.05) increased levels of plasma glucose (281.10 mg/dL) and decreased levels of insulin (6.01 μU/mL). Additionally, diabetic rats showed a significant (p < 0.05) increased levels of plasma lipid profiles such as total cholesterol (149.05 mg/dL), triglycerides (143.28 mg/dL), free fatty acids (139.37 mg/dL), phospholipids (127.53 mg/dL), plasma low-density lipoprotein-cholesterol (98.72 mg/dL), plasma very low-density lipoprotein-cholesterol (28.65 mg/dL), and significant (p < 0.05) decreased in plasma high-density lipoprotein-cholesterol (21.68 mg/dL). When galangin was administered to the hyperglycaemic rats, plasma glucose and insulin levels and lipid profiles reverted to levels similar to those in healthy control rats.Discussion and conclusions: Administration of galangin reduced hyperlipidaemia related to the risk of diabetic complications and could be beneficial for diabetic hyperlipidaemic patients. Further work detailing its mechanism-of-action for improving hyperglycaemic-associated lipid abnormalities is needed.

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Section: Discussionmentioning

confidence: 99%

Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia

Aloud

Veeramani

Govindasamy

et al. 2018

Pharmaceutical Biology

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“…Besides, the in‐vitro anti‐oxidant activity of the fruit, leaves, and seeds of S. dulcificum has been studied and was responsible by phenolic compounds and polysaccharides (Du, Shen, Zhang, Prinyawiwatkul, & Xu, 2014; Njoku, Ubbaonu, Alagbaoso, Eluchie, & Umelo, 2015). The anti‐diabetic effect of the fruit and leaves of this plant were found in rats (Obafemi, Akinmoladun, Olaleye, Agboade, & Onasanya, 2017). The butanol extract of the fruit, aqueous fraction of seeds extract, and methanolic extract of leaves all possessed anti‐hyperuricemia (Shi et al, 2016), anticonvulsant (Jeremiah, Ilesanmi, & Ige, 2015), and anti‐cancer (Seong, Oyong, & Cabrera, 2018) activities, respectively.…”

Section: Introductionmentioning

confidence: 99%

The cholesterol‐lowering activity of miracle fruit ( Synsepalum dulcificum )

Huang

Chung

Xuan³

et al. 2020

J Food Biochem

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Miracle fruit (Synsepalum dulcificum) is famous for its uniqueness of modifying sour taste to sweetness. However, its cholesterol‐lowering activity has not been reported. This study investigated the effect of S. dulcificum on the compositional changes of plasma lipids in hamsters fed a high‐cholesterol control diet. Six groups of hamsters were fed either a control diet or one of the five experimental diets containing 2% ethanol extract of leaves, 2% water extract of leaves, 2% ethanolic extract of seeds (ES), 2% water extract of seeds, or 2% dry pulp. Results showed that ES decreased the plasma total cholesterol (TC). Two triterpenoids (lupeol acetate and β‐amyrin acetate) were isolated from the ES and they added to a diet could decrease TC by 15%–20% in hamsters. It was concluded that ES showed potent TC‐lowering activity and triterpenoid was one of the active components of ES. Practical applications In recent years, people are more interested in phytochemicals from functional foods treated for hyperlipidemia because they possessed fewer side effects than the synthetic drugs. The triterpenoids isolated from the miracle fruit may be promising candidates for the development of cholesterol‐lowering agent, especially for patients whose blood cholesterol level and body weight are high. Meanwhile, the miracle fruit have a good potential as cholesterol‐lowering functional food or a natural source of cholesterol‐lowering agent.

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“…Flavonoid mampu meregenerasi sel beta pankreas dan membantu merangsang sekresi insulin (Dheer and Bhatnagar, 2010). Selain itu, konsumsi flavonoid atau senyawa kaya flavonoid melindungi tubuh terhadap radikal bebas dan senyawa pro-oksidatif lainnya, sehingga mengurangi risiko diabetes (Obafemi et al, 2017). Antioksidan dapat ditemukan dalam berbagai sumber makanan.…”

Section: Pendahuluanunclassified

Teh Rambut Jagung dengan Penambahan Daun Stevia sebagai Alternatif Minuman Fungsional Bagi Penderita Diabetes Melitus Tipe 2

Akbar

Arini

Fauziyah

2019

J. Apl. Teknol. Pang.

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Rambut jagung merupakan salah satu limbah tanaman jagung yang kurang pemanfaatannya namun mengandung antioksidan (flavonoid) yang dipercaya dapat menurunkan kadar glukosa darah. Penelitian ini secara umum bertujuan untuk mengembangkan formulasi teh dari rambut jagung dengan penambahan daun stevia sebagai alternatif minuman fungsional bagi penderita diabetes melitus tipe 2. Metode yang digunakan adalah eksperimental dengan menggunakan desain rancangan acak lengkap. Penelitian meliputi proses pembuatan ekstrak rambut jagung, pembuatan formulasi teh rambut jagung, analisa organoleptik meliputi uji hedonik dan mutu hedonik dengan parameter uji warna, aroma dan rasa, dan analisis zat gizi teh. Terdapat tiga konsentrasi teh rambut jagung, yaitu 20, 30, dan 40%. Formula terbaik hasil uji organoleptik adalah formula penambahan ekstrak rambut jagung sebesar 40% dengan kandungan air, abu, protein, lemak, karbohidrat masing-masing sebesar 99,6, 0,20, 0,14, 0, dan 0,06%, sedangkan total flavonoidnya sebesar 0,03%. Kesimpulannya, kandungan flavonoid dalam teh rambut jagung dapat memenuhi kebutuhan konsumsi flavonoid laki-laki per hari sebanyak 51,7% dan 37,5% untuk perempuan dengan takaran saji 250 ml. Kandungan kimia yang dimiliki teh rambut jagung dengan penambahan daun stevia berpotensi untuk dijadikan alternatif minuman fungsional.Corn Silk Tea with Additional of Stevia Leaves as an Alternative Functional Beverage for People With Diabetes Mellitus Type 2AbstractCorn silk was known as one of the corn waste that lacks utilization but contains antioxidants (flavonoids) that were believed to suppress blood glucose levels. The purpose of this study was making tea from corn silk with the addition of stevia leaves as a functional beverage for people with diabetes mellitus type 2. This study used experimental method and completely randomized design. The research included the process of manufacture corn silk extract, compose corn silk tea formula, organoleptic analysis including hedonic testing and hedonic quality with color, aroma and taste, and lastly, analysis of tea nutrition. Three silk corn tea formulas were composed in a various concentrations, i.e. 20, 30, and 40%. The best formula from organoleptic test was formula with the addition of 40% corn silk extract which was containing of 99.6% water, 0.20% ash, 0.14% protein, 0% fat, 0.06% carbohydrate, and flavonoids total of 0.03%. In conclusion, the flavonoid content in corn silk can meet the consumption needs of male flavonoids per day by 51.7% and 37.5% for women with a serving dose of 250 ml.

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Antidiabetic potential of methanolic and flavonoid-rich leaf extracts of Synsepalum dulcificum in type 2 diabetic rats

Cited by 46 publications

References 35 publications

Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia

Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia

The cholesterol‐lowering activity of miracle fruit ( Synsepalum dulcificum )

Teh Rambut Jagung dengan Penambahan Daun Stevia sebagai Alternatif Minuman Fungsional Bagi Penderita Diabetes Melitus Tipe 2

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