The present study shows that galangin decreased oxidative stress and increased antioxidant status in diabetic rats, which may be due to its antidiabetic and antioxidant potential.
We designed this study to observe the effect of galangin on damaged mitochondria in the liver of diabetic rats. Methods: Male albino Wistar rats were made diabetic by injecting streptozotocin (STZ) intraperitoneally (40 mg kg −1 body weight (BW)). Galangin (8 mg kg −1 BW) or glibenclamide (600 µg kg −1 BW) was given orally daily once for 45 days to both healthy and diabetic rats. Results: Diabetic rats showed significant (P < 0.05) increase in liver mitochondrial oxidant [Thiobarbituric acid reactive substance (TBARS)] level and a significant decrease in enzymatic [superoxide dismutase (SOD), glutathione peroxidase (GPx)] and non-enzymatic (reduced glutathione (GSH)) antioxidant levels when compared with healthy rats. The mitochondrial enzymes isocitrate dehydrogenase (ICDH), alpha-ketoglutarate dehydrogenase (α-KGDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) and mitochondrial respiratory chain enzymes NADH-dehydrogenase and Cytochrome c-oxidase were decreased significantly (P < 0.05) in diabetic rats when compared with healthy rats. A natural flavonoid galangin administered to hyperglycemia-induced rats resulted in the following findings as compared to hyperglycemiainduced control rats: the oxidant levels decreased significantly (P < 0.05); the enzymatic and nonenzymatic antioxidant levels increased significantly (P < 0.05) and the function of mitochondrial enzymes and the mitochondrial respiratory chain enzymes increased significantly (P < 0.05). Conclusion: From the results, we conclude that galangin could maintain liver mitochondrial function in diabetic rats.
Context: Galangin, a natural flavonoid, is found in honey and Alpinia officinarum Hance (Zingiberaceae). Galangin has antiviral, antimicrobial, antidiabetic and anticancer properties, without side effects. The effects of galangin on hyperglycaemia and lipid abnormalities are not known.Objective: To elucidate the effectiveness of galangin on hyperglycaemia-associated complications and lipid changes in rats with streptozotocin (STZ)-induced hyperglycaemia.Materials and methods: Diabetes was induced in adult Wistar rats by administering 40 mg/kg of STZ. In our previous study, galangin had no toxicity at concentrations up to 320 mg/kg. Therefore three doses of galangin (4, 8 or 16 mg/kg BW) or glibenclamide (600 µg/kg BW) were administered daily to diabetic rats orally for 45 days.Results: Diabetic rats showed a significant (p < 0.05) increased levels of plasma glucose (281.10 mg/dL) and decreased levels of insulin (6.01 μU/mL). Additionally, diabetic rats showed a significant (p < 0.05) increased levels of plasma lipid profiles such as total cholesterol (149.05 mg/dL), triglycerides (143.28 mg/dL), free fatty acids (139.37 mg/dL), phospholipids (127.53 mg/dL), plasma low-density lipoprotein-cholesterol (98.72 mg/dL), plasma very low-density lipoprotein-cholesterol (28.65 mg/dL), and significant (p < 0.05) decreased in plasma high-density lipoprotein-cholesterol (21.68 mg/dL). When galangin was administered to the hyperglycaemic rats, plasma glucose and insulin levels and lipid profiles reverted to levels similar to those in healthy control rats.Discussion and conclusions: Administration of galangin reduced hyperlipidaemia related to the risk of diabetic complications and could be beneficial for diabetic hyperlipidaemic patients. Further work detailing its mechanism-of-action for improving hyperglycaemic-associated lipid abnormalities is needed.
This study was piloted to assess the fusion of nanoparticles (LCCaNP) from leaf extract of Lavatera critica (LC) and calcium chloride and to observe their impact on the safety of fresh‐sliced fruits and extend their shelf life. LCCaNP were synthesized by mixing calcium chloride and LC leaf extract, followed by the addition of sodium hydroxide. The quality of the produced LCCaNP was proven by conducting different physical and chemical tests. Fresh apples, strawberries, and guavas were independently immersed in diverse concentrated LCCaNP and 2% calcium chloride solution for 5 min. These treated sliced fruits were stuffed in polypropylene plastic bags and stored at 5°C. The total soluble solid content (TSS), pH, firmness, and weight reduction rate, 2,2‐diphenylpicrylhydrazyl (DPPH), and sensory analysis were conducted for the total storage period of 25 days in a 5‐day interval. LCCaNP and calcium chloride were proficient to preserve the fruits for up to 20 days. Our findings showed that LCCaNP‐treated fresh‐sliced fruits had an improved and enhanced shelf‐life than control (nontreated) samples. In conclusion, the leaf of LC is an eventual source for the making of calcium oxide nanoparticles and could serve as an improved food conservation with proficiency to extend the fruit's shelf life for up to 20 days. Novelty impact statement For the first time had produced the natural LCCaNP from a natural plant of LC and evaluated its impact on the safety of fresh‐sliced fruits. The natural nanosized LCCaNP is successfully produced by using the natural Ayurvedic plant of LC. LCCaNP acted as a better food preservative and had the capability to extend the shelf life of apples, strawberries, and guavas for up to 20 days without causing any side effects.
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